Top Tweets for #RNAInDisease
The 4th of the #RNASummerSchool 2022 at @CEITEC_Brno @muni_cz🧬
🇪🇺“European Day”: From #RNAInDisease to #DrugDesign
@KelAdaPharma @imbmainz @embl @univienna @WTcell
@biotweeps @RNASociety Our paper on #exRNA #RNAinDisease and #aging was recently published in @AgingCell Check it out at: https://t.co/OardduuLc6
@biotweeps @RNASociety We study post-transcriptional regulation of mRNAs and noncoding RNAs in the brain, and how their dysregulation leads to #RNAinDisease. We have become particularly interested in repeat-containing RNAs that cause >30 neurological disorders including ALS, FTD, and DM @biotweeps
I work with RNA G-quadruplexes in untranslated regions and how they drive localisation and local translation of neuronal mRNAs. Loss of such controlled processes can lead to neuro developmental disorders & mental retardation #RNAInDisease @biotweeps
As we discuss #RNAInDisease, I would now like to try a crowdsourcing experiment. I would like to invite everyone working on RNA biology (@RNASociety) to make a short tweet thread about your work and its relevance to disease research. Please @bioweeps & use #RNAInDisease hashtag.
@biotweeps @RNASociety We are examining extracellular RNA #exRNA and #aging, which has implications for #RNAinDisease since the prevalence of many diseases, including #Cancer, increases with aging.
@biotweeps @RNASociety We study how the speed of ribosome movement on RNAs affects protein synthesis. Something that is dysregulated in diseases from ribosomopathies to cancer. #RNAinDisease
Are there different mechanisms to achieve the same outcomes? Answering basic questions in the context of development can inform drug design by understanding what "normal" is and how it is achieved. Example: harnessing X chromosome reactivation in Rett syndrome #RNAInDisease
@biotweeps @RNASociety I’m interested in understanding how interactions between cellular environment and #RNA modifications impact gene expression and cellular identity in #cancer #RNAInDisease
@biotweeps @RNASociety We study regulatory elements at the 5’ untranslated region of cellular mRNAs whose expression drives cancer and tumor development under various stress conditions@biotweeps and@RNASociety #RNAInDisease
While #RNAInDisease hashtag is picking up steam, I want to address another topic that I promised I would: work-life balance as a scientist. #WorkLifeBalance
@biotweeps @RNASociety We found a novel pathway in neurons that resembles retroviral transport of RNA cell-to-cell. The neuronal gene Arc forms viral-like capsids that can transfer RNA! We think this has implications for memory and neurodegenerative diseases. #RNAInDisease https://t.co/OP682FNvvr
@biotweeps @RNASociety In @hjosephyost’s lab, I’m studying the role of miRNAs in heart development and their role in congenital heart disease #RNAInDisease
@biotweeps #RNAInDisease we study the mechanisms that transmit small RNA memory across multiple generations in C.elegans. The relevance of this process to disease remains to be discovered, BUT, “relevance” is hard to predict!
As we discuss #RNAInDisease, I would now like to try a crowdsourcing experiment. I would like to invite everyone working on RNA biology (@RNASociety) to make a short tweet thread about your work and its relevance to disease research. Please @bioweeps & use #RNAInDisease hashtag.
@biotweeps @RNASociety We study how individual adenosines are converted to inosines (RNA editing) and how this process is regulated. This is a normal cellular process required for proper development and neuronal function, but goes awry in cancer and neuropathological diseases #RNAInDisease
@biotweeps @RNASociety I study lncRNAs in heart development, and the role they may play in congenital heart disease. We know most of the causes of CHD are genetic but don't know the causative genes. It's likely that some of this is explained by non-coding RNAs which act as regulators #RNAInDisease
#RNAInDisease Here in Prof Chris Smith's lab, we study how Alternative splicing can affect vascular smooth muscle cell phenotypes with relevance to cardiovascular diseases incl atherosclerosis.
@biotweeps @RNASociety The only work I did with RNA got published few years ago and it was on RNA aptamers. https://t.co/Qtgj2Pp7fq it was cool to see that good correlation of computational and experimental work. #RNAInDisease
@biotweeps @RNASociety I study transfer of mRNA between cells through special protrusions called tunneling nanotubes (a.k.a. membrane nanotubes). We suspect it plays a role in shaping cellular micro-environment & might affect cancer progression, embryonic development, viral infection #RNAInDisease
@biotweeps @RNASociety #RNAInDisease We study RNA regulatory mechanisms controlling human steroidogenesis. We are interested in A) RNA regulatory dynamics underlying steroid production, and B) molecular mechanism of trans-acting regulatory factors controling steroidogenesis RBPs and lncRNAs.
@biotweeps @RNASociety We study post-transcription regulation of the innate immune response and how changes to RNA processing can impact bacterial and viral infection outcomes @RNASociety @biotweeps #RNAInDisease
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