Top Tweets for #SHQuickByte
#SocHemepath #SHQuickByte
High-grade B-cell lymphoma with MYC and BCL6 rearrangements, leukemic phase
Neoplastic cells may mimic a variety of other lymphoid and myeloid neoplasms
#leusm #lymsm #hemepath
#SocHemepath #SHQuickByte
Crystal-Storing Histiocytosis in Plasma Cell Myeloma
Accumulation of crystalline material in histiocytes, in this case, kappa immunoglobulin
#mmsm #hemepath
#SocHemepath #SHQuickByte
Bone marrow (systemic) mastocytosis
Abnormal aggregates of spindled mast cells with associated eosinophils and benign lymphoid aggregate.
Activating KIT mutation
This case was associated with B-LL (not shown)
#hemepath #leusm
#SocHemepath #SHQuickbyte
Acute Promyelocytic Leukemia, PML-RARA+, FLT3-ITD mutated with classic sliding-plate morphology
FLT3-ITD mutation is seen in ~35% of APL and is associated with high WBC, hypogranular variant morphology, and short PML-RARA isoform
#hemepath #leusm
#SHQuickByte #SocHemepath
Lymph node sinus showing benign histiocytes with a signet-ring cell appearance.
This is an uncommon benign finding with no known significance.
DDx = metastatic carcinoma
#hemepath #leusm #lymsm #pathology
#SocHemePath #SHQuickByte
Hypersegmented neutrophil (defined as >5 lobes).
Seen in megaloblastic hematopoiesis (e.g. folate or B12 deficiency, treatment with 6-MP or methotrexate) and less often in sepsis, renal disease, and myeloproliferative neoplasms #hemepath #leusm
#SocHemepath #SHQuickByte
Sea-blue histiocyte (marrow aspirate)
Large, lipid-containing cells are more common in disorders associated with high cell turnover.
Lipid storage disease (e.g. Niemann-Pick)
CML
Myelodysplastic syndromes
Other conditions
#hemepath
#SocHemepath #SHQuickByte
Osteosclerosis with paratrabecular fibrosis (bone marrow).
Benign etiologies include chronic kidney disease (this case), hyperparathryoidism, or autoimmune disease.
#BSTpath #Hemepath
#SocHemepath #SHQuickbyte
T-cell prolymphocytic leukemia is a rare, aggressive leukemia.
Cells often show cytoplasmic blebs on the blood smear (arrow)
CD4+ (60%), CD4+CD8+ (25%), CD8+ (15%) TCL-1 (usually +)
inv(14) is seen in 80% of cases
#hemepath #leusm #lymsm
Langerhans cell histiocytosis (LCH), #SHQuickByte submitted by our faculty Dr Rosado @FlaviaRosadoMD
QUESTION
*** Can one of the path trainees name the mutation + in ~50% of LCH (also + in hairy cell leukemia and Erdheim Chester)?*** #pathboards
#SHQuickbyte
Langerhans cell histiocytosis: Characteristic LCH cells are oval cells with grooved, folded or indented nuclei, and abundant cytoplasm (arrows)
Unlike normal Langerhans cells, LCH cells are devoid of dendritic processes
#hemepath #LCH #SHQuickbyte
#SHQuickbyte
Langerhans cell histiocytosis: Characteristic LCH cells are oval cells with grooved, folded or indented nuclei, and abundant cytoplasm (arrows)
Unlike normal Langerhans cells, LCH cells are devoid of dendritic processes
#hemepath #LCH #SHQuickbyte
#SHQuickByte: Early lymph node involvement by anaplastic large cell lymphoma (ALCL) may be limited to the sinuses.
Typically, CD30 shows uniform strong staining of ALCL cells in a "rim and dot" (i.e. cell membrane and Golgi) pattern
#lymsm #pathology #hemepath
#SHQuickbyte Hematoidin is a Hb-derived pigment sans iron (related to bilirubin). Formed intracellularly it can be seen extracellularly >5 days in previous hemorrhage.
Seen as refractile, yellow-brown granules or rhomboid plates arranged in a radial pattern (hematoidin burrs)
Found in pathological conditions (MDS, excessive alcohol use, Pb poisoning, Cu deficiency etc) RS should not be confused with normal ferritin sideroblasts.
In MDS a high prevalence of somatic mutations in 𝘚𝘍3𝘉1 has been reported/end
#hemepath #shquickbyte #MDS #𝘚𝘍3𝘉1
Found in pathological conditions (MDS, excessive alcohol use, Pb poisoning, Cu deficiency etc) RS should not be confused with normal ferritin sideroblasts.
In MDS a high prevalence of somatic mutations in 𝘚𝘍3𝘉1 has been reported/end
#hemepath #shquickbyte #MDS #𝘚𝘍3𝘉1
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