Top Tweets for #STEREOCILIA
In this recent study, Anna Underhill (@sheffielduni) and co-authors concluded that Myosin 7a is required for maintaining the transducing #stereocilia and for force #transmission to the MET channel during #cochlear hair cell development ๐ง ๐ฌ
๐ https://t.co/uleUg429Kd
๐In #auditory hair cells, the EVL protein is expressed in the cuticular plate, an #actin-rich meshwork that supports #stereocilia.
๐ญDoes EVL have an auditory or balance function in mice?
โกhttps://t.co/qF9qxqJ6iz
#GeneKnockout #InnerEar
We find members of the TMC family of putative #mechanosensors at the tips of #intestinal #microvilli! @BecharaKachar
Modeling @Angelative and molecular dynamics simulations @LabSotomayor suggest they may be ion channels and/or lipid scramblases, like TMC1 at #stereocilia tips!
Transmembrane channel-like 4 and 5 proteins at microvillar tips are potential ion channels and lipid scramblases https://t.co/hrHK2rLzRA #biorxiv_cellbio
The #Rac1 and Rac3 localization at #stereocilia, apical #celljunctions, and lateral membranes in cochlear HCs. Both Rac1 and/or Rac3-DKO mice exhibited normal cochlear morphology and normal hearing function.
#Phenomics #JournalofMolecularMedicine
https://t.co/xy4Xalu5wV
SIM & surface rendering reveals that #InnerEar #HairCells constantly supply #stereocilia building blocks to the hair bundle, but the unique protein composition at the tips of each row of stereocilia ensures that the rows grow differentially #PLOSBiology https://t.co/UHzhw1VvA9
SIM & surface rendering reveals that #InnerEar #HairCells constantly supply #stereocilia building blocks to the hair bundle, but the unique protein composition at the tips of each row of stereocilia ensures that the rows grow differentially #PLOSBiology https://t.co/UHzhw1VvA9
SIM & surface rendering reveals that #InnerEar #HairCells constantly supply #stereocilia building blocks to the hair bundle, but the unique protein composition at the tips of each row of stereocilia ensures that the rows grow differentially #PLOSBiology https://t.co/UHzhw1VvA9
The #cochlea is lined with minuscule hairs called stereocilia. These hairs convert the stimulation from sound waves into electric signals to the brain. Sensorineural #hearing loss occurs when something goes wrong with the #stereocilia. ๐
Learn more: https://t.co/genHmhgF1B
Explore the data now @EMDB_EMPIAR & @PDBeurope
#EMPIAR: https://t.co/RyfVKN8qZi
#EMDB: https://t.co/VHxGYxRitW
#PDBe: https://t.co/Yag3ilkXXs
Related: https://t.co/iQXt3Zt8Fn
#EMPIAR1k #StructuralBiology #CryoEM #Helical #Myosin-15 #Actin #Stereocilia #Biology #Science
3/3
The 1,000th #EMPIAR entry released @EMDB_EMPIAR is the image data that led to the 3.6 ร
#CryoEM #Helical structure of ADP state wild-type #Myosin-15 in complex with filamentous #Actin; important for #Stereocilia that are responsible for sound detection
https://t.co/dpEP8nPWpw
1/3
Great data from Jung-Bum Shin, showing XIRP2 is important for #repair of noise-induced damage to #Stereocilia F-Actin cores and highlights the gaps in understanding of #Stereocilia repair. #ARO2022 @AROMWM @spARO_news
Amazing work by Xufeng Qiu, from the Mueller lab, showing CIB2 is required for the normal transport of TMC proteins into #stereocilia and CIB2 directly affects #MET_channel function. #ARO_2022 @AROMWM
@HopkinsMedicine
@spARO_news
Fantastic insights into #stereocilia dynamics.
@ZaneGMoreland from @JBird_Lab suggests that a MYO15-CETN2 phase condensate contributes to the formation of the #stereocilia tip density. #ARO2022 @AROMWM @spARO_news @UF
mechanisms of #stereocilia length regulation is not well understood. Peter Barr-Gillespie illustrates that tip-links coordinate stereocilia lengths, and EPS8/MYO15A localize to #stereocilia tips in the independently of GNAI3. #ARO2022 @AROMWM @spARO_news
Xiayi Liao from the Perrin lab suggest there is a population of short #actin filaments at #Stereocilia tips, uncovering a possible novel mechanism for actin turnover. #ARO2022 @ARO2022 @spARO_news @IUSM_Oto @IUImpact
Molecular motors are essential for proper #stereocilia dynamics and elongation. James Heidings from the Bird lab @UF show that MYO15A binds to CETN2 and CETN2 drive the multimerization of MYO15A. #ARO2022
@AROMWM
#Myosin #Actin_cytoskeleton
Dr. Behnammanesh shows a novel isoform of Myo15 (isoform 3) traffics EPS8 to the tips of the #stereocilia tips and there is #isoformswitching during cochlea aging and maturation. #ARO2022 #cochlea
Itโs nice and quiet in the house, itโs a beautiful sunny morning and my #SEM #stereocilia data is back ๐ ๐from @AnwenBullen #auditory #hearing #cochlea #science #ear
TMIE listening to the "Putting the Pieces Together: The Hair Cell Transduction Complex" symposium @AROMWM. #mechanotransduction #hearing #cochlea #METChannel #stereocilia
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