Top Tweets for #StopCA
Thanks for having me on your episode @OPCILive to talk about our #STOPCA clinical trial in #CardioOnc
OPCI's latest Journal Club features @SaadMahmoodMD of @StFrancis_LI discussing "Atorvastatin for Anthracycline Associated Cardiac Dysfunction" with panelists @djc795 @rooshaparikh and Dr. Glenford Robinson. Watch now at https://t.co/g9OltqFw7D. #CardioTwitter
Great to see our #STOPCA trial out in @JAMA_current . Fond memories of consenting the 1st trial participant, weekly multi center trial meetings, bio banking etc. Was an incredible year as part of @TomasNeilan lab.
@mariellesc1 #CardioOnc @CHS_LI @StFrancis_LI
Among study participants with lymphoma who were being treated with anthracyclines, prophylactic use of atorvastatin over 12 months was associated with a lower rate of cardiac systolic dysfunction. https://t.co/JZVqaltrYA
💡BREAKING #CardioOnc NEWS💡
The landmark #STOPCA randomized clinical trial on atorvastatin for Anthracycline-Associated Cardiac Dysfunction has just been published in @JAMA_current
A big congratulations to @TomasNeilan and @mariellesc1 👏
@SABOURETCardio @gbiondizoccai In recent #ACC23 was presented #STOPCA study with Statin. Does this study reinforce the use of statin in patients with Cancer ? @gbiondizoccai @SABOURETCardio
🌟 @DrRaulCordoba shares his wisdom on #JACCCardioOnc #Pulse! 🌟
♦️ Key topics ♦️
1⃣ When #hematology 🩸 meets #cardiology 🫀 (#cardiohematology? 🤔)
2⃣ #Cardioonc in 🇪🇸
3⃣ #Geriatrichematology pearls
4⃣Reflections on #STOPCA on statin use in lymphoma
https://t.co/LLwXC1yyid
@priyankapophali @psharmaMD @graham74GC @CwynKate I would give my thoughts but there is nothing better yet compared to this thread by @Ron_Witteles #STOPCA #cardioonc @ICOSociety @TomasNeilan @mariellesc1
🚨(1/9) STOP-CA trial reports positive results at #ACC23, showing cardiac protection of atorvastatin for patients treated with anthracyclines. But last year’s similar trial was negative! What to believe?🤔A 🧵…
Check out #JACCCardioOnc #Pulse content from #ACC23! Listen to discussion b/w @Ron_Witteles @GregHundleyMD @mariellesc1 & #BonnieKy on #STOPCA trial findings, differences w/ PREVENT trial, & key points about risk-guided #cardioprotection @JACCJournals https://t.co/mlOMiRXomC
Nice one, @mmamas1973. And here's the link to @lamckeown1's #STOPCA coverage:
https://t.co/WOGubrehAc
My @TCTMD interview with @TomasNeilan and @mariellesc1 around STOP-CA trial. Statin use and prevention of anthracyclin related CV toxicity ➡️ https://t.co/eNxqUEOU20 @mirvatalasnag @hvanspall @Hragy @DrMarthaGulati @iamritu @MinnowWalsh @ditchhaporia @HeartDocRx @HeartBobH
Congrats to Cornell alum &🫀esteemed Cardio-oncologist @SaadMahmoodMD and coinvestigators on their LBCT #CardioOnc trial #STOPCA. #ACC23
🚨 Looking forward to release of our late breaking clinical trial at #ACC23.
We randomized 💊 #Statins Vs Placebo in #Anthracycline recipients. #STOPCA
Come by Great Hall Sat March 4 @ 10:10a to hear the incredible @TomasNeilan . 🎙️
#LBCT #CardioOnc.
https://t.co/SRTOZGrsXL
ICYMI: Best approach to #LVEF assessment in #CardioOnc trials debated at #ACC23/#WCCardio #LBCT via #STOPCA
Check out #SUCCOUR: International RCT w/ 3-year outcomes. EF & global longitudinal strain guided cardioprotection showed improvement w/ no difference b/w groups. New approaches (eg: exercise) needed? https://t.co/mmsQI1wk0T
#JACCIMG #cvImaging #CardioTwitter
#ACC23 Late-breaking Interview🎙️
🔥 Results & implications of the #STOPCA with Co-PI, Dr @mariellesc1
Watch 📺 +📊👉 https://t.co/8z188z3sCd
🫀At 12Ms 64 pts (21%) in the entire cohort had a ⬇️ in the LVEF of ≥ 5% from prior to chemotherapy to a value of <55%
#Cardiotwitter
@CIRC_MGH well represented @zsofidrobni @quinagliathiag1 @HannahGilman5 at #ACC23 presentation of the results of #STOPCA by group leader @TomasNeilan. Congratulations to co-PI @mariellesc1 and Tom for this ground breaking study in #CardioOnc 👏
Always amazing to see this #WIC on the main stage. Exceptional clinician, scientist and a big sponsor to all the #WICs around her! @AnaBaracCardio so proud to know you! #ACC23 @ACCinTouch #StopCA
@iamritu @chiarabd @karen_ordovas @womenincmr @JStojanovskaMD @onco_cardiology
#STOP-CA Statins TO Prevent the Cardiotoxicity From Anthracyclines Tomas Neilan
pts randomized to 40 mg atorvastatin 🆚 placebo at 12 months had 1.3 % change in #echofirst LVEF(primary endpoint) 9% in atorvastatin 🆚 22% placebo P=0.002 safe no significant adverse events #ACC23
STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines) double blind, multicenter, place-control trial ; statins demonstrated cardioprotective effect in patients undergoing anthracyclines-based chemo (lymphoma) #LateBreakingTrial #CardioOnc #ACC23 #STOPCA #NOLA 🤯🤯🤯
📣 Hot topic: Cardio Onc & the #STOPCA trial
🟣Statins to prevent cardiac toxicity
Quick refresher:
🟣Anthracyclines are known to cause cardiac toxicity
🟣Begins w/ first cycle of therapy
🟣Associated with a 10-15 fold increased risk of CHF
#cardionerds #ACC23 @CardioNerds
#STOPCA Trial
❓Do statins ⬇️ cardiotoxic effects of anthracyclines in Lymphoma pts
💊 atorvastin 40mg prior to chemo x 12 mo
💊High doses of anthra used #
✅ 3 fold ⬇️ EF in statin group vs placebo
Limitations of #STOPCA below @AnaBaracCardio led a great discussion #WCCardio #ACC23
🫀challenges in such a population and yet excellent follow up
🫀 50% women but not very diverse
🫀 unclear effect past 12 m
🫀no change in lipids
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