Top Tweets for #TPD23
Dinner time at #TPD23: it took four of us & several hours to convince @danetteldaniels that lenalidomide does not fulfill the criteria of a high quality degrader probe. Now we are all members of the women in TPD network. With @mader_mary, Joachim Rudolph, Zoran Rankovic
"Congratulations to @HartungIngo, Marcel Rieker on the successful disclosure of their #PROxAb shuttle technology at #TPD23. Truly innovative work by @undruggable! Looking forward to seeing impact of your plug-and-play platform for delivering VHL-based #PROTACs to diseased cells
It was a proud moment yesterday when my colleague Marcel Rieker disclosed our #PROxAb shuttle technology at #TPD23 @Undruggable. Along with the poster by Hendrik Schneider they outlined our plug-and-play platform for delivering VHL-based #PROTACs to diseased cells. @merckgroup
@HartungIngo @Undruggable @merckgroup Great work on showcasing your #PROxAb shuttle technology at #TPD23! It's exciting to see the potential of your plug-and-play platform for delivering VHL-based #PROTACs to diseased cells. Impressive collaboration, Marcel Rieker, Hendrik Schneider, and @merckgroup! #Innovation
Today I am going to talk about quality criteria for degrader probes at #TPD23 @Undruggable. Small molecule degraders have great potential as drugs but also as tools to discover novel biology. But quality matters for all such tools. How to assess the quality of degrader probes?
It was a proud moment yesterday when my colleague Marcel Rieker disclosed our #PROxAb shuttle technology at #TPD23 @Undruggable. Along with the poster by Hendrik Schneider they outlined our plug-and-play platform for delivering VHL-based #PROTACs to diseased cells. @merckgroup
While dual inhibition of CBP & EP300 bromodomains causes thrombocytopenia in mice, designing selective degraders for either of the two allows overcoming this safety limitation at doses sufficient for selective target degradation. By Steve Ballon @foghorntx at #TPD23 @Undruggable
Strong data set disclosed by Steven Sparks @ArvinasInc at #TPD23 showing degradation of brain #LRRK2 by an orally dosed #PROTAC in non-human primates. Another frontier in the #TPD space about to be overcome! Disease-causing proteins in neurological diseases now in scope!
Warm & sunny today in Catalunya but swimming rather not an option. Unless somebody would want to step in for me at #TPD23 in Boston next week…
TPD TV PICCADILLY PARTY 🪩
Party of the year TONIGHT - for the FIFTH time in a row 🤩
11:30pm.
@OfficialRandL #RandL #RandL23 #TPD23
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