Top Tweets for #VGC2
#SickleCellDisease Haplo PTCy
For children, haploidentical BMT with thiotepa + PTCy requires additional strategies to decrease graft failure rates
#VGC2
International collaborative phase 2 trial haplo BMT with thiotepa and PTCy Pediatrics and adult https://t.co/gA2m4ChwqR
2-year EFS: 82.6%.
OS at 2 years: 94.1%.
10% acute GVHD rate; 10% moderate-severe chronic GVHD at 2 years.
100% donor chimerism by day +180
@Satyayadav__
Sickle Haplo PTCy #VGC2
Overall survival 94%
Graft failure 11.4% (8/70) & only in participants <18 years (p=0.001)
1-year gr III-IV acute GvHD rate was 10.0% & 2-year moderate-severe chronic GvHD rate was 10.0%
Five participants (7.1%) died from infectious complications
Congratulations @DrAdetolaKassim @josudelafuente , @CarmemBonfim1 and other Vanderbilt Global consortium for cure members.. I have learnt a ton from all of you on this learning platform https://t.co/pgAmQvVrIo
@DrAdetolaKassim presenting #VGC2 outcomes #haploidentical #BMT #SickleCell : #excellent #outcomes in #adults & abrogation of #GraftFailure in #children with #hypertransfusions & #hydroxycarbamide @VUMCHemOnc together with @ImperialPaeCH & worldwide centres
This yr had the wonderful opportunity to work with collaborative groups on projects for #ASH20 Oral presentation by @josudelafuente #bmtsm #SickleCell from the #VGC2 consortium Mon Dec 7th 8:15 am👇Non MA Haplo HCT for SCD
#PTCy with non-myeloablative approach feasible and leads to donor engraftment across HLA barrier and variety of donors in #thalassaemia presented by #VGC2 @ImperialNHS @imperialcollege @VUMCHemOnc @VanderbiltU @ClevelandClinic #TCTM20
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