Top Tweets for #ValvularInterstitialCell
#Autophagy #Senescence #MitralValveDisease
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
https://t.co/xSQDKWpwJI
#SpatialTranscriptomics Human Embryonic Heart 8.4 9.7 pcw
Visium @10xGenomics
+snRNAseq
Contrast to vessel-nerve alignment, aortic valve leaflet is encircled but not invaded by nerve sprouts⬅️ 🧐Repulsive signals from #ValvularInterstitialCell #ValvularEndothelialCell (#EndMT)?
@Dev_journal 2025
https://t.co/UP6tP9efmn
#CalcificAorticValveDisease
In vitro evidence for TRPM4 cation channel in ⏫#Calcification of #ValvularInterstitialCell
How an ion channel⏫#Osteogenesis?➡️A possible Ca2+-NFAT-BMP2-SMAD1/5-RUNX2 cascade🤔
@JAHA_AHA 2025
https://t.co/tDEnt7S54R
#Valvulogenesis #Elastogenesis #Pigmentation
Melanocyte-like (Acta2+Tyr+) #ValvularInterstitialCell is the major depositor of Elastic Fiber in🐭developing aortic valve
Also, subpopulations of Vim+ interstitial cells or Cdh5+ endothelial cells are elastin-depositing
"In mice, the aortic valve is pigmented and contains cells that express melanocytic markers, such as Mitf, Dct, Trp1, Tyr"
Valvular elastin fiber
⏫in hyperpigmented K5-Endothelin 3🐭
⏬in Albino (Tyr mutant) 🐭
+P3 #SpatialTranscriptomics Visium🤓
Aortic Valve vs surrounding Myocardium
@joshdhutch @SciReports 2024
https://t.co/3lxAsx8qDq
3D Aortic Valve-On-A-Chip #CalcificAorticValveDisease
2-Layered hydrogel
#ValvularEndothelialCell + #ValvularInterstitialCell in Collagen (Fibrosa)
VIC in Collagen/GAG (Spongiosa)
+Uniaxial #CyclicStretch 10%
#FluorescenceLifetimeImaging #OpticalRedoxRatio
#Proteomics
Modeling early metabolic reprogramming of CAVD
⏬#Glycolysis
+other interesting traits Proteasome, NAD+, Ufmylation...
@IshitaTandon2 @DrKartikBala @ActaBio 2024
https://t.co/UUjG1tLuA5
#ValvularInterstitialCell #Senescence & #AorticValveCalcification
CyclinD1 siRNA⏬osteogenesis+senescence of cultured VICs
How? siCCND1➡️
1⃣⏫NRF2, HMXO-1 & NQO1 (antioxidant defense)
2⃣⏫TRIM25 E3 ligase➡️⏬KEAP1, which sequesters NRG2 in cytosol?
Morusin? What is it?🫥
Adv Sci 2024 @AdvSciNews
https://t.co/RwT5SGXLXv
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