Top Tweets for #aav9
Congrats to Dr. Angela Price for completing the 1st direct #vagus_nerve_injection in humans for clinical trial of #AAV9 vector for autonomic dysfunction in #GAN. @UTSWMedCenter @UTSWBrain #Neurosurgery
Across 10 NHP studies, AAV9 expression efficiency favored CNS over liver independent of administration route, age, or construct. Data supports epigenetic silencing as a key liver barrier.
🔗https://t.co/MRvUuCNIWN
#AAV9 #NHP #GeneTherapy #Genomics
Great way to improve mRNA translation based on our @CellRepMed paper showing miR-dependent suppression. @EugenioCingolan #mRNA #3’UTR #translation #AAV9 @EMBO
New @EMBO paper: 3′UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation. https://t.co/IvGdOoEkwm
Focused ultrasound intrathecal delivery of #AAV9-SaCas9 boosts brain editing: ~2000× more hippocampal Cas9 and fewer pathogenic glycogen inclusions with lower neuroinflammation in a #LaforaDisease mdoel
🔗 https://t.co/6NGXra4Vd4
AAV9 and convection-enhanced delivery into the olfactory bulb reveals extensive transduction across memory circuits, opening new paths for gene therapy in #neurodegenerative diseases. Read more here ⬇️
https://t.co/wIeENNwTiE
#AAV9 #GeneTherapy
Systemic delivery of an AAV9 exon skipping vector significantly improves or prevents features of Duchenne muscular dystrophy in the Dup2 mouse
👉 10.1016/j.omtm.2022.07.005
@KevinMFlanigan
#DuchenneMuscularDystrophy #DMD #GeneTherapy #ExonSkipping #AAV9 #U7snRNA #Dup2MouseModel
📢 New paper alert: autonucleolytic suspension HEK line for high-titre serum-free #AAV5 and #AAV9 production with reduced DNA impurity.
Nice one Geoff and colleagues at @ucl BioEng 👏🏼
@School_Pharmacy @UCLResearch @_BSGCT @MolTherapy
Delighted to share the latest publication from the Nesbeth lab, my second first-author manuscript. We engineered suspension HEK cells to express a secretory nuclease which reduced DNA impurities and (serendipituously) increased AAV yields!
https://t.co/XDbyHKrDxG
@GenePlumber
We're excited to share a new publication in @NatureNano describing early foundational research on an engineered, systemically delivered #AAV capsid that more effectively transduces the brain compared to #AAV9. @Caltech
Read more: https://t.co/LUTlsXqaJ6
Fengfeng Bei, PhD, NSU research faculty member, and team "have designed two promising #AAV9 variants that are more effective than the parent vector for delivering #therapeutic #transgenes into the central nervous system of two animal models." Read more! https://t.co/AMy5QiAQvi
Online now, #AAV9 mediated #genedelivery of the SMn2B/- gene in #SMA #iPSC derived motor neurons in vitro and in a neonatal SMA mouse model restores SMN protein levels. Read #GTArticle here➡️https://t.co/LV72qNW9td
🧪: @RJYanezMunoz's lab @RoyalHolloway
📸: SMA iPSC-derived MNs
Trending now, #intrathecal injection of #AAV9-mediated HGF #genedelivery reduces astrogliosis in the motor cortex of #ALS animal models. For more, join our #GTReaders here now➡️https://t.co/V8qD1MIqiH
Work by @NorthwesternU Helixmith Co. & @SNUnow
📸: ©iStock
Online now, #intrathecal injection of #AAV9-mediated HGF #genedelivery reduces astrogliosis in the motor cortex of #ALS animal models. Read #GTArticle here now➡️https://t.co/kUcPLjGvxr
Work by @NorthwesternU Helixmith Co., @SNUnow
📸: ©iStock
📢 $1️⃣8️⃣0️⃣,0️⃣0️⃣0️⃣ grant from @cureSYNGAP1 🇺🇸 and 🇬🇧 to Prof. Cobb & Prof. Kind of the @PWCentre @EdinburghUni - already a #SynGAP research center - to advance gene 🧬 therapy for #SYNGAP1 with #AAV9 SRF quotes by @Cdnchick74 & @JMGraglia.
#Collaboration
https://t.co/5Mild5fCtF
Researchers engineer family of adeno-associated #viralvectors that cross #bloodbrainbarrier in primate models, advancing efforts to develop #genetherapies for #neurologicaldiseases. https://t.co/SW14T3yH4o #AAVs #viralvector #AAV #AAV9 #viralcapsids #capsids #viruses #genetherapy
Researchers engineer family of adeno-associated #viralvectors that cross #bloodbrainbarrier in primate models, advancing efforts to develop #genetherapies for #neurologicaldiseases. https://t.co/mGq1PRlY4N #AAVs #viralvector #AAV #AAV9 #viralcapsids #capsids #viruses #genetherapy
💡 NEW RESEARCH - Doan et al. assess the thermostability & in vivo performance of #AAV9 in a film matrix | @UTexasPharmacy
https://t.co/NqPH3fNtsx
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