Top Tweets for #catecholamines
Adrenal–adipose tissue crosstalk in health and disease by Mingyan Jiang et al
EJE Volume 193, Issue 6, December 2025
👉 https://t.co/SRDxLyVExk
ESE members free via 👉 https://t.co/AxTMoXOoqV
#endocrinology #steroids #catecholamines #paraganglioma #aldosteronism #adipokines
amphetamines thc social media music fortnite all at once
my dopamine system LOVES ME
#catecholamines
🚨🚨 RA & ANS: C. Stress Response - When the Sympathetic System Hits the Panic Button
#StressResponse #RAandANS #SympatheticNervousSystem #FightOrFlight #SympathoadrenalAxis #HPAaxis #Catecholamines #PerioperativeMedicine #AnesthesiaEducation #RegionalAnesthesia #CriticalCare #Neurophysiology #MedEd
#TipOfTheDay #MyRATips
Tip of the Day:
💥 What is the stress response?
It’s the body’s fight-or-flight reaction to pain, fear, hypovolemia, hypoxia, or surgery.
And it has TWO parallel arms 👇
1️⃣ ⚡ FAST ARM: Sympathetic–Adrenal Medulla system (SAM)
🔹 🧠 Trigger : sudden stress (pain, anxiety, laryngoscopy, blood loss)
🔹 🛣️ Pathway :
Spinal cord (T1–L2) ▶️
Thoracic splanchnic nerves ⏩
Adrenal medulla
🔹 🧪 What’s released into blood:
🧬 Epinephrine
🧬 Norepinephrine
🔹 ⏱️ Speed :Seconds (very fast)
🔹 🎯 Effects :
❤️ ↑ Heart rate & contractility
🩸 ↑ Blood pressure
🫁 Bronchodilation
🧠 ↑ alertness
🍬 ↑ Blood glucose
👉 This is the immediate survival response
2️⃣ ⏳ SLOW ARM: HPA axis (Hormonal stress response)
🔹 🧠 Hypothalamus → CRH
🔹 🧠 Pituitary → ACTH
🔹 🧠 Adrenal cortex → Cortisol
🔹 ⏱️ Time: Minutes to hours
🔹 🎯 Effects:
Maintains BP
Sustains glucose supply
Modulates inflammation
Supports prolonged stress
💉 Where RA fits in
🟢 HOW RA does well
✨ Blocks nociceptive input
✨ Reduces sympathetic outflow
✨ Blunts catecholamine surge
✨ ↓ Stress response to surgery
⚠️ But here’s the catch
❌ High spinal / epidural:
May block Peripheral sympathetic tone & Adrenal medulla input
👉 Result:
Hypotension
Bradycardia
Poor stress compensation
🟢 Why peripheral nerve blocks are safer hemodynamically
✔️ They do not block splanchnic nerves
✔️ Adrenal stress response is preserved
✔️ Better cardiovascular stability
🎯 Take Home:
🔹 The stress response has a FAST sympathetic–adrenal component and a SLOWER hormonal component.
🔹 RA modulates this response by reducing afferent pain signals and sympathetic outflow, but excessive Neuraxial blockade may abolish essential compensatory mechanisms.
⚡ RA & ANS: B. Sympathetic System & Adrenals - The Direct Hotline
#SympatheticNervousSystem #AdrenalMedulla #StressResponse #SympathoadrenalAxis #AnesthesiaEducation #RegionalAnesthesia #Neuroanatomy #PerioperativeMedicine #AutonomicNervousSystem #Catecholamines
#MyRATips #TipOfTheDay
Tip of the Day:
🧠 Key concept
The adrenal medulla is a modified sympathetic ganglion.
🛣️ How sympathetic fibers reach the adrenal gland
➡️ Origin
Preganglionic sympathetic neurons arise mainly from T5–T9 spinal segments
➡️ Exit from spinal cord
Ventral root → spinal nerve → white ramus communicans
➡️ Sympathetic chain
Fibers pass through the chain without synapsing
➡️ Splanchnic pathway
🔹 Greater splanchnic (T5–T9)
🔹Lesser splanchnic (T10–T11)
➡️ Adrenal entry
Preganglionic fibers synapse directly on chromaffin cells
🔥 What makes the adrenal medulla unique
➖ No postganglionic neuron
➖ No gray ramus
➖ No peripheral nerve travel
➡️ Preganglionic fiber → adrenal medulla → bloodstream
🧪 Neurochemical mechanism
🔹 Acetylcholine released from preganglionic fiber
🔹 Acts on nicotinic receptors
🔹 Chromaffin cells release:
➡️ Epinephrine (~80%)
➡️ Norepinephrine (~20%)
📢 Hormones enter circulation, not synapses
💉 Clinical relevance in Regional Anesthesia
➡️ Spinal / epidural anesthesia
↓ Sympathetic tone → ↓ adrenal catecholamine response → hypotension
➡️ High spinal anesthesia
Loss of both: → Peripheral sympathetic tone → Adrenal stress response
➡️ Peripheral nerve blocks
Do not affect adrenals (splanchnic nerves spared)
🎯 Take Home
➡️ Preganglionic sympathetic fibers (T5-T9) bypass the sympathetic chain and directly innervate the adrenal medulla via thoracic splanchnic nerves, making it a modified sympathetic ganglion.
Torre et al shows for the first time that the ionic mechanism of the #HR by #catecholamines is generated by two autonomous mechanisms, mediated by L-type Cav1.3 (alpha1D) channels & hyperpolarization-activated cAMP-
gated #HCN channels. https://t.co/Zbx3Lp2lMK
📣Call for Reading:
#Article
Plier Ligands for Trapping Neurotransmitters into Complexes for Sensitive Analysis by SERS Spectroscopy
by Olga Eremina, et al.
https://t.co/cljHUNeAdE
#catecholamines #dopamine #Neurotransmitter #SERS #biomarker
#biosensors #mdpi #openaccess
🎉 Huge congratulations to Zachary McKenna for winning @ajpregu's Best Short Report for 2024! Proudly honored at #APS2025!
👉https://t.co/2N0x5aYWko
@ZachMcKenna_PhD #Catecholamines
➡️Separate and combined blockades of α- and β-adrenergic receptors in forearm sweating induced by adrenergic agents and exercise in the heat in young adults (@amano_tatsu et al.)
🔗https://t.co/mTt9hU7u4X
@naotofuj @HEPRU_uOttawa @kiwiheatlab #Adrenoreceptors #catecholamines
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg https://t.co/mxR0zSteeM
#PPGLs #hypertension
Today's #PharmFamilies is on #sympatholytics, which target adrenergic neurons in the central #NervousSystem & prevent them from releasing #catecholamines.
Learn more: https://t.co/Inal1Rxcb9
Try Osmosis from Elsevier for free: https://t.co/RNC5Mb7Dr3
New in @AJPRegu "Adrenal epinephrine facilitates erythropoietin gene activation by hypoxia through β2 adrenergic receptor interaction with Hif-2α" by Xiaoyu Su et al.
https://t.co/gpNElm5Edp
#Catecholamines #SympatheticNervousSystem #ProteinKinaseA
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced #hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg https://t.co/mxR0zSteeM
#PPGLs #hypertension
🔥 NEW #epinepherine & #heat research from Zachary J. McKenna et al:
Plasma epinephrine and norepinephrine responses to extreme heat exposures in young and older adults
https://t.co/MZl4B0eOdR
#catecholamines
@ZachMcKenna_PhD
@caitlin_jarrard
@joshfoster_phd
@whitleyatkins
Trending Research:
In this compelling review, Roberto Zatz & @GilbertodeNucci examine isolated #vascular tissues and propose that #catecholamines contribute more to the control of vascular tone & heart functions than once thought.
👉https://t.co/IWs9nUpEXd
Study shockingly reveals that Catecholamines and Catecholaminergic drugs can interfere with human testicular functions
https://t.co/Z4Nph9s3tZ
#MedicalNews #Catecholamines #Males #MensHealth #Men #USA #America #UnitedStates #Boston #Europe #Britain #France #Germany #Thailand
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced #hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg https://t.co/mxR0zSteeM #PPGLs
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced #hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg https://t.co/mxR0zSteeM
#PPGLs
And if you’re anywhere in the realm of #sepsis #septicshock #vasopressors #catecholamines #priorities then you would not want to miss @ESICM @SCCM joint session @skanegill @criticcaredoc we can’t wait to share what we have learnt with the world! @SOCCA_CritCare
#Catecholamines—noradrenaline and adrenaline—in excess, can lead to catecholamine-induced #hypertension (CIH) and more severely a CIH crisis, with a high risk of life-threatening #cardiovascular complications https://t.co/mxR0zSsGpe
#phaeochromocytomas #paragangliomas #PPGLs
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced hypertensive (CIH) crises https://t.co/mxR0zSsGpe #PPGLs
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