Top Tweets for #cd28
Last night’s launch was powerful. Over 500 friends, families, and neighbors came together because South Texas is ready for a new chapter rooted in faith, hard work, and hope.
This campaign isn’t about me, it’s about a mission. A mission to serve with integrity, to lift the dark cloud over our community, and to answer the calling God has placed on my heart.
I’m running because South Texas deserves a leader who shows up, who listens, and who fights for our future with corazon.
Thank you to everyone who stood with us. The work begins now. UN ABRAZO GRANDE
If Texas only Had Tano last week… We wouldn’t have had a shutdown with Temu…
@JudgeTano for 28!!!
#LetsGo @TexasGOP @GOP #CD28
$CRVS oral ITK inhibitior soquelitinib induces #iTregs, similar to "Sakaguchi recipe" that blocks CD28
#CD28 costimulation key in ITK pathway
Expect ITKi = similar stable FOXP3+ expression, more suppressive iTregs for treatment of autoimmune diseases
https://t.co/vevL5CKPQv
𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐒𝐩𝐨𝐭𝐥𝐢𝐠𝐡𝐭: Recent Nobel winner Shimon Sakaguchi and his colleagues have published two new papers demonstrating how to convert T-cells into Tregs to treat autoimmune diseases. @chloeckirk explains.
Links: https://t.co/0vyWAzTRjl https://t.co/pbmPcgs4Pq
This "overstimulation" chronic activation leads to exhausted Tcells. Why mechanisms that reduce the T-cell stimulation or interrupt can be so powerful to reverse T-cell exhaustion. #ITK integrates #TCR signal and #CD28 co-stimulation, but if you inhibit ITK you dampen signal and lead to increased tumor fighting and stem-like self-renewing CD8+ Tcells that have memory like capability for strong anti-tumour response.
$CRVS ITK inhibitor begins Ph1b/2 solid tumour trial in next few months to show this powerful effect and synergy with anti-PD1 therapy.
Paper on ITK for co-stimulation:
https://t.co/D3LoOQFGdE
Paper on inhibiting ITK for overcoming immunotherapy resistance and synergistic effect
https://t.co/UxVKT3j9Dt
New Paper shows #CD28 signaling is dispensable for #Treg generation, as support for ITK inhibition resulting in long-duration + strongly suppressive Tregs:
We know $CRVS oral #ITK inhibitor #soquelitinib MOA reduces strength of TCR/CD28 co-stimulation and this paper’s conclusions support Tregs are being made by ITKi including #epigenetic changes in #TSDR i.e., reduced demethylation and increased acetylation which I previously discussed which make #FOXP3+ persistent and results in more suppressive Tregs for treating #autoimmune disesases, i.e. #atopicdermatitis, #foodallergies, #asthma, etc.
Explains long-duration benefit $CRVS is seeing in atopic dermatitis study with disease control still occurring 60 days after treatment stopped. Looking forward to hearing more on this novel mechanism and Treg effect on May 7, 2025 in San Diego.
Paper exerpt comments:
“Continuous oral antigen administration combined with CD28 co-stimulation blockade generates a specific type of antigen-specific functionally stable #pTreg cells, which can establish long-term systemic antigen-specific immune tolerance even in antigen-pre-sensitized animals. This strategy for mucosal tolerance induction would be instrumental in treating chronic allergy and other immunological diseases in humans.”
"Consistent with this, we found that iTreg cells generated without CD28 signal indeed expressed CD101 at higher levels than those produced with CD28 signal (Fig. 5A and 5B). Moreover, CD28-deficient Tconv cells more efficiently differentiated into iTreg cells with higher expression of CD101 compared with CD28-intact Tconv cells;”
"Thus,CD28 signaling is dispensable for iTreg generation, especially in the presence of IL-2. CD101expression could be attributed to the reduction of CD28 co-stimulatory signal in iTreg generation."
"These findings when taken together suggest that CD101 plays a role in modulating TCR and CD28 signaling, especially the latter, required for pTreg development in the intestine and iTreg generation from Tconv cells, and likely their induction of anergy in the absence of CD28 signal. The molecular basis of the function of CD101 and its ligand, which is currently unknown, remains to be determined. Nevertheless, CD101 could be a useful marker for pTreg cells, especially those induced by CD80/CD86low tolerogenic DCs, which transduce TCR signal with reduced CD28 signal."
Note: CD101, a heavily glycosylated member of the immunoglobulin superfamily, is expressed on regulatory T cells (Tregs) and its expression is associated with increased Treg suppressive capacity, potentially playing a role in regulating inflammation and autoimmune responses.
New Paper shows #CD28 signaling is dispensable for #Treg generation, as support for ITK inhibition resulting in long-duration + strongly suppressive Tregs:
We know $CRVS oral #ITK inhibitor #soquelitinib MOA reduces strength of TCR/CD28 co-stimulation and this paper’s conclusions support Tregs are being made by ITKi including #epigenetic changes in #TSDR i.e., reduced demethylation and increased acetylation which I previously discussed which make #FOXP3+ persistent and results in more suppressive Tregs for treating #autoimmune disesases, i.e. #atopicdermatitis, #foodallergies, #asthma, etc.
Explains long-duration benefit $CRVS is seeing in atopic dermatitis study with disease control still occurring 60 days after treatment stopped. Looking forward to hearing more on this novel mechanism and Treg effect on May 7, 2025 in San Diego.
Paper exerpt comments:
“Continuous oral antigen administration combined with CD28 co-stimulation blockade generates a specific type of antigen-specific functionally stable #pTreg cells, which can establish long-term systemic antigen-specific immune tolerance even in antigen-pre-sensitized animals. This strategy for mucosal tolerance induction would be instrumental in treating chronic allergy and other immunological diseases in humans.”
"Consistent with this, we found that iTreg cells generated without CD28 signal indeed expressed CD101 at higher levels than those produced with CD28 signal (Fig. 5A and 5B). Moreover, CD28-deficient Tconv cells more efficiently differentiated into iTreg cells with higher expression of CD101 compared with CD28-intact Tconv cells;”
"Thus,CD28 signaling is dispensable for iTreg generation, especially in the presence of IL-2. CD101expression could be attributed to the reduction of CD28 co-stimulatory signal in iTreg generation."
"These findings when taken together suggest that CD101 plays a role in modulating TCR and CD28 signaling, especially the latter, required for pTreg development in the intestine and iTreg generation from Tconv cells, and likely their induction of anergy in the absence of CD28 signal. The molecular basis of the function of CD101 and its ligand, which is currently unknown, remains to be determined. Nevertheless, CD101 could be a useful marker for pTreg cells, especially those induced by CD80/CD86low tolerogenic DCs, which transduce TCR signal with reduced CD28 signal."
Note: CD101, a heavily glycosylated member of the immunoglobulin superfamily, is expressed on regulatory T cells (Tregs) and its expression is associated with increased Treg suppressive capacity, potentially playing a role in regulating inflammation and autoimmune responses.
Oral antigen exposure under co-stimulation blockade generates Treg cells to establish immune tolerance despite prior sensitization
https://t.co/SDNZoW3pQU
This is what a paid Cartel asset looks just like.
Look also no further than Corrupt @RepCuellar for using his Congressional seat to benefit the bad guys. #Doge #CD28
🔍 Hier, l’#EscapeGame pédagogique Traque Le Hack a été joué au collège Pierre Brossolette de #NogentLeRotrou avec deux classes de 3e. 🎭💻
Une action menée dans le cadre du #CD28 @eurelien pour sensibiliser à l’#IdentitéNumérique et aux bons usages du numérique ! 🚀🔐
🎲 Hier, au collège Soutine de St-Prest (28), 2 classes de 5e ont exploré les stéréotypes de genre avec "C'est Cliché", un jeu de plateau coopératif pour sensibiliser à l'égalité fille-garçon.
🙏 Merci à @eurelien pour son soutien !
#egaliteFG #Stéréotypes #CD28
🎤 Séance 3 avec le CDJ28 @eurelien !
🎶 Projet "Chanter contre le harcèlement" : place à la créativité aujourd'hui avec un atelier d'écriture pour donner vie aux paroles de la chanson. 📝
#Éducation #ÉgalitéFG #CD28 #harcèlement
Hier, 2e séance avec le CDJ28 @eurelien !
🔎 Retour sur le projet voté l’an dernier : Chanter contre le #harcelement
🎲 Comprendre, identifier, agir face au harcèlement avec le jeu de l'oie (MAE)
📝 Travail sur la chanson : ébauches, planification et vote
#ÉgalitéFG #CD28
Great to see Rondo Therapeutics teaming up with @EliLillyandCo in a collaboration to develop novel #CD28 #bispecific #antibodies for solid #tumors. Congrats to the Rondo team, including Canaan's @nkjellson, who sits on the board.
https://t.co/1g29lMv5JG
Cheating is baked into their winning formula.
#Cheat #Election #Ballots #Cuellar #CD28 #ElectionIntegrity #BexarCounty #trump
#ElonMusk #Democrats #Recount
⏪Hier, les jeunes élus du Conseil départemental des jeunes du 28 ont plongé dans un #EscapeGame "Filles et garçons à égalité" 🚀 ! En équipes, ils ont exploré, créé et présenté des supports pour l’égalité. 👏 Bravo pour leur engagement ! 🎉 #Éducation #ÉgalitéFG @eurelien #CD28
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