Top Tweets for #dualpayload

We’re excited about the dual payload thesis because it ensures tumor cells are exposed to *both* payloads at once vs. the conditional probability that multiple ADCs deliver to the same cell. We think this matters most when the dual payload strategy leverages cargoes that, when delivered together, show potentiated or synergistic efficacy vs. delivering two payloads that might not have an additive effect (i.e. when delivering a TOPOi + MTI on a single ADC). Multi-ADC strategies might be preferable if the IC50 of the two payloads are so far apart that you need to dose at very different levels not achievable with today’s DAR thresholds on one ADC, or if you’re trying to control for distinct temporal exposure of payloads. COGS and the complexities around co-formulating two hydrophobic molecules might also limit a multi-ADC approach. That said, there’s some exceptional science going on wrt ADC engineering today - the future feels bright!