Top Tweets for #hdac6
Novel Glioblastoma Therapy Alert!
Epigenetic targeting of KYN–HDAC6–Complement in GBM
Epigenetics Congress 2026
March 30–31 | San Francisco, CA, USA
Website: https://t.co/QAs4CyXHoj
#Epigenetics2026 #Glioblastoma #CancerTherapy #HDAC6 #NeuroOncology
♾️ In(SPIR)ed by SPIRO ! At the @DeptPharm_Unina we have unveiled a new #SPIROcyclic cap-group for selective #HDAC6 inhibition!
🎗🎗🎗 We dissected anticancer mechanisms underlying selective HDAC6 inhibition in #TripleNegativeBreastCancer.
https://t.co/mIiWqfTuOJ
Augustine Therapeutics closes $85M series A for #HDAC6 inhibitors https://t.co/xY69XDdwev #biopharma #financing
Excited to share our latest work on an exquisitely selective #PROTAC of #HDAC6 in #JMedChem @ACSBioMed @ACSPublications!! TO-1187 is a highly potent HDAC6 degrader with complete proteome selectivity, sparing all #CRBN neosubstrates and other #HDAC isoforms.
New Paper Alert! See our joint @SynBioC - @VIB_CMB work on #HDAC6 ubiquitin-binding domain inhibitors published in Eur. J. Med. Chem. https://t.co/vsira1eAyc @ELSchemistry, in collaboration with @UofT @LabScribbles, @KU_Leuven, @CSB_UGent, @XStruct_group. @FbwUGent
Just like all roads lead to Rome...most of the mechanisms underlying #TNBC converge on #HDAC6 as a common thread and a valuable therapeutic target.
Read our last review at:
https://t.co/WISnXmdlQ3
and....stay tuned for more evidence coming from #SPOTSLab @DeptPharm_Unina
Excited to share our paper on preferential HDAC6 inhibitors derived from HPOB, showing synergistic antileukemia activity with decitabine! Huge congratulations to the team! @sanilbhatia5 #HDAC6 #Decitabine https://t.co/IE0aevysCf
Flight one day late, bag another. But British Airways can´t stop me: On my way to #FloHet2024! Excited to be back at my postdoc university @UFChemistry and to present our recent results on difluoromethyl-1,3,4-oxadiazole-based selective #HDAC6 inhibitors and #PROTACs @FloHetConf
This is a great write-up about the origin and success of @HDAXtx, a startup founded by some of our amazing alumni that has raised $1.3 million to develop #HDAC6 inhibitors with a novel "two-site binding modality" for the treatment of #peripheralneuropathy!
#gunningalumni
#UofT startup targets harmful side effect of cancer treatment #UofTEntWeek 🧪 https://t.co/XzqDGdZVMH
Excited to share our latest Viewpoint on 2‑(difluoromethyl)-1,3,4-oxadiazoles (DFMOs) as selective #HDAC6 inhibitors and #degraders. Congratulations to my PhD student Beate! https://t.co/gTFay86qhI
Chong Kun Dang Pharmaceutical stock rallied on Monday on news of its biggest-ever $1.3 billion out-licensing deal with Novartis.
#Korean_novel_drugs #rare_diseases #CKD_510 #Charcot_Marie_Tooth #HDAC6 #CMT #Novartis #NCE #PMA #HMSN #out_licensing
https://t.co/s8lpj0mVCY
Happy to share our newest preprint dealing with the multi-component synthesis of selective #HDAC6 inhibitors with anti-inflammatory properties. Congrats to first author Fabian and everybody involved. Great in-house collaboration with the Weindl lab! https://t.co/5Q9AI67bfi
New preprint: Difluoromethyloxadiazoles are mechanism-based and essentially irreversible #HDAC6 inhibitors. An enzyme-catalyzed ring opening reaction forms the active species: a difluoroacetylhydrazide. Another amazing collaboration with @ChristiansonLab! https://t.co/Icy0O5DrJK
Congratulations to the Jubilant team on their publication of research in @PLOSONE on JBI-097, a dual LSD1/HDAC6 #inhibitor, which suggests comprehensively targeting the #LSD1 & #HDAC6 complex can enhance therapeutic response when compared to other agents.
https://t.co/k01QatAagX
10: Researchers from the Cone lab found that blocking the activity of an enzyme inside fat cells (#HDAC6) improved sensitivity to leptin—a metabolism-regulating hormone—leading to weight loss and better overall metabolic health in mice. https://t.co/zKQZQMfJtl
The lysosomal Ragulator complex activates #NLRP3 #inflammasome in vivo via #HDAC6
Hyota Takamatsu, Atsushi Kumanogoh and coworkers @osaka_univ_e
https://t.co/a1UuWSBWBU
@thesgconline in collaboration with Professor @MarkLautens developed a first-in-class #chemicalprobe for #HDAC6 ubiquitin binding domain. Learn more here: https://t.co/ZVqjSr21QN
@chemuoft @BijanMirabi @labscribbles
#chemicalprobe #openscience
@thesgconline in collaboration with Professor Mark Lautens developed a first-in-class chemical probe for #HDAC6 #ubiquitin binding domain. @chemuoft @MarkLautens @BijanMirabi @labscribbes https://t.co/sTdWC3arhM .
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