Thrilled to share our #OpenAccess online resource "An Introduction to Medicinal Chemistry & Molecular Recognition" on @OpenLibraryON! We designed this resource to provide budding medicinal chemists with the knowledge & tools to navigate small molecule drug discovery! #OER
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—outgrowth of decades of NIH funded research
https://t.co/HmJxYWDCV7
https://t.co/4DsNELnBut @NEJM
https://t.co/y7NMGPpXnE
NEW SITE LAUNCH! https://t.co/aJ9BgdKfVn
NEW! Researchers & Scientists: https://t.co/DOvaQq3FHH
NEW! Patient & Caregiver Resources
https://t.co/159YcwPM18
NEW! Projects Funded
https://t.co/CpyaXUbkch
NEW! Community
https://t.co/ssmRrYQE6Y
#braincancer
In case you missed it:
'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development'
Fom Patrick Gunning and colleagues at @GunningLabUofT
https://t.co/URQzvQhoNo
@HartungIngo@Glaconde34@ProtDegraders As Tobi mentioned, one explanation could be the relatively short PEG1-triazole linker which may cause the pyridyl arm of the HDAC6 ligand to sterically preclude neosubstrate recruitment.
@HartungIngo@Glaconde34@ProtDegraders It surprised us too, since most of the 4-alkylamino-substituted CRBN recruiters we've seen show some degree of neosubstrate degradation, but the proteomic data was quite convincing and corroborated by Western blots. (1/2)
Excited to share our latest work on an exquisitely selective #PROTAC of #HDAC6 in #JMedChem@ACSBioMed@ACSPublications!! TO-1187 is a highly potent HDAC6 degrader with complete proteome selectivity, sparing all #CRBN neosubstrates and other #HDAC isoforms.
Take a look at 'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development'
New from Patrick Gunning and colleagues at @GunningLabUofT
https://t.co/URQzvQhoNo
We optimized conventional conditions for fluorothalidomide SNAr (overnight, oil bath heating) to achieve improved yields on gram-scale in only 15 minutes under microwave irradiation, exemplifying the method by preparing the clinically explored PROTAC #bavdegalutamide (ARV-110)!
Check out our paper on proton pump inhibitor activation in cells in @NatureChemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@RedoxDKFZ). More collabs between our groups @DKFZ to come! https://t.co/oYt2rHEF0D
🗞️
"Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F–13C two-dimensional NMR" ⤵️
@UofT &+
With #NSERCsupport.
Congrats to Motasem in the #Prosserlab and our recent co-supervised alumnus @geordifrere for publishing a new story on tryptophan-based 2D 19F-13C NMR in @rsc_chembio!
Excited to share our new paper in @rsc_chembio on improving resolution in fluorotryptophan protein NMR by expanding into the 13C dimension! We prepared & used a 13C-labelled F-Trp precursor to achieve unprecedented spectral resolution of a F-Trp-bearing protein by 2D 19F-13C NMR!
pharmacophore-optimized photoaffinity fragments-based hit discovery with improved hit rate and better sensitivity, and multiple binding sites, reported by @keserulab@GunningLabUofT
https://t.co/HbHZWUUyqY
Congratulations to our Sr. Researcher Associate @GeletuMulu for receiving the Rosemary Brown Outstanding Mentorship Award at @CanBlackSci's #BlackExcellenceInSTEMM conference!! Mulu's commitment to scientific mentorship in our community is nothing short of inspiring.
#BESTEMM2024
Delighted to congratulate Dr. @geordifrere for defending his PhD thesis on the design of #monovalent electrophilic protein degraders & novel probes for protein-observed 19F #NMR! Geordi is an expert synthetic chemist & our resident scientific lectiophile!
#PrOFNMR#covalent#TPD
@NSERC_CRSNG@UTM_CPS@J_A_C_S You can read more about Geordi's graduate journey by reading @TheMediumUTM's article featuring him! He discusses his path towards chemistry, describes the joy and wonder of creating new molecules, and shares some advice for prospective graduate students.
https://t.co/3XPlnBMrOC
Our PhD student @geordifrere was featured in the latest issue of @TheMediumUTM! Geordi is a talented medicinal chemist in our lab working on the development of covalent protein degraders as well as new ways to enable site-selective ligand discovery by NMR!
https://t.co/OIC8ZaILtL