Top Tweets for #hyperfiltration
7/ #Hyperfiltration and kidney failure are the same disease at different stages: starting with overload, ending with burnout. What matters is how the kidney function changes over time
💡Watch the trajectory, don’t wait for the decline
6/ #Hyperfiltration predicts kidney decline, CVD and mortality. Thus, elevated eGFR requires context- trajectory, age, clinical setting- as it signals early cardiovascular vulnerability, not a standalone diagnosis
5/ #Hyperfiltration is a risk phenotype: cardiometabolic & hemodynamic stress raise single-nephron workload, making high filtration biologically expensive.
👉 examples: obesity, diabetes, hypertension, and insulin resistance
Our recent work is now published in Kidney International Reports.
🔗 https://t.co/ZLxIR5wxl1
@KIReports
#Nephrology #CKD #Hyperfiltration #PrecisionMedicine
Severe obesity associates with maladaptive glomerular haemodynamics clustered with insulin resistance and endothelial dysfunction. Moriconi et al. https://t.co/JIrA5JHCwR @CKJsocial #CKD #Hyperfiltration #arterialstiffness #endothelium #GFR #obesity #nephrology
🍃What are the benefits of a plant-dominant low protein diet?
🖊️#Plant-Dominant Low-Protein #Diet: https://t.co/KOPlx17YHx
@Nutrients_MDPI
#dietary #hyperfiltration
⚜️Glomerular hyperfiltration is an independent predictor of postoperative outcomes: A NSQIP multi-specialty surgical cohort analysis
⚜️https://t.co/eREtXHz7Ox
@WileyHealth
#Hyperfiltration
#NephTwitter
#MedEd
Lingyan Fei & co-workers discovered vasodilator action of Piezo1 in acute #hyperglycemia contributing to #hyperfiltration in #diabetes. Caption: Authors pictured on top of #Charité research building.
https://t.co/cvfa8Ar6u9
#EDNSG
European Diabetic Nephropathy Study Group- Nantes 2023
#Nantes #diabetes #nephropathy #hyperfiltration #diabetes #EASD
The Beneficial Effects of Bariatric-Surgery-Induced Weight Loss on Renal Function
https://t.co/dzGojlFtU1 #mdpimetabolites via @MDPIOpenAccess
#adiponectin #RAAS #hyperfiltration #leptin #nephrology
Our paper has been published on Diabetes Care 🥳
Glomerular #Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 #Diabetes: A 21-Year Longitudinal Study.
#nephrology #MedTwitter #eGFR #mGFR #CKD
#kidney #kidneydisease
https://t.co/TlJ2C9gPmH
28b)
👉#Pathology: glomerulomegaly in #diabetes = adaptation to #hyperfiltration
👉#RCTs: dual RAS/SGLT2 inhibition prevents progression of #CKD +/- #diabetes at unprecedented effect size (🔓https://t.co/BkDuLoRsTX)
22) Frequently, multiple factors combine that enhance single nephron #hyperfiltration & require structural #adaptation, for which human capacity is quite limited before irreversible injury occurs, e.g., #podocyte detachment from intolerable shear stress.
https://t.co/MGJzHJOIyp
51) So, in parting . . . in people with #T1D and kidney #hyperfiltration the addition of a #SGLT2i in people taking ramipril causes?
a) ⤵️ Intraglomerular pressure
b) ⤵️ Total peripheral resistance
c) ⤵️ Oxidative stress markers
d) All the above
8b) Consequently a dilation of the afferent arteriole occurs, producing an increase in #GFR, known as glomerular #hyperfiltration in the initial stages of evolution of diabetes mellitus.
8b) Consequently a dilation of the afferent arteriole occurs, producing an increase in #GFR, known as glomerular #hyperfiltration in the initial stages of evolution of diabetes mellitus.
Glomerular hyperfiltration in morbid obesity: role of the inflammasome signaling https://t.co/0KaxpwS7Gb
#hyperfiltration #obesity #nephrology
28b)
👉#Pathology: glomerulomegaly in #diabetes = adaptation to #hyperfiltration
👉#RCTs: dual RAS/SGLT2 inhibition prevents progression of #CKD +/- #diabetes at unprecedented effect size (🔓https://t.co/BkDuLoRsTX)
22) Frequently, multiple factors combine that enhance single nephron #hyperfiltration & require structural #adaptation, for which human capacity is quite limited before irreversible injury occurs, e.g., #podocyte detachment from intolerable shear stress.
https://t.co/MGJzHJOIyp
10) Hyperfiltration is ≥25% ⬆️ in GFR secondary to
- afferent arteriolar vasodilation
- efferent arteriolar vasoconstriction
thereby ⬆️intraglomerular pressures
🔓https://t.co/V1uZIZFOX6
https://t.co/jBnJwtNdhm
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