Top Tweets for #jefferies17
AUTO4/5, probably the smartest project in Autolus’s R&D pipeline #Jefferies17
E.Moses $ABLX at #Jefferies17 “since the Hercules data, I haven’t heard an aTTP KOL saying anything else than they would treat every patients with caplacizumab”
Autolus conditioning DLBCL patients with PD1 MAb in AUTO3 study #Jefferies17
Autolus contrasts AUTO2 approach vs $BLUE & Nanjing Legend, which both selected high BCMA expressors #Jefferies17
Autolus R&D pipeline and IP #Jefferies17
No change in entrectinib strategy after $LOXO $BAY. $RXDX says it’s still looking to retain US, partner ex-US #Jefferies17
$RXDX says $LOXO $BAY deal is net +ve: validates TRK and leaves entrectinib as only unencumbered asset #Jefferies17
$RXDX Axl competition for $BGBIO.OL ? #Jefferies17
Itin reckons Autolus's first foray into solid tumours will involve: persistence, turning -ve TME signals +ve, creating CAR-T cell that becomes insensitive to checkpoint inhibition #Jefferies17
Yeesus mentions the elephant in the room: with $GILD Kymriah (& poss $JUNO ) coming in 2018 for DLBCL how soon before CAR-T becomes a price war? #Jefferies17
On cell therapy pricing, Choulika $CLLS says there's one thing "no one talks about": big pharma minimum floor is 85% gross margin. Anything less and a drug is not profitable #Jefferies17
Gene therapy pricing? Webster ( $ONCE ): If it works pay us. If not, stop paying us #Jefferies17
What still needs to be done to improve on 1st approved CAR-T products? Choulika $CLLS : manufacturing pressure over time of delivery to patient #Jefferies17
Looking forward to discussing @Ignyta's #PrecisionMedicine pipeline of #targetedtherapies for #cancer at #Jefferies17
#Jefferies17 cell therapy pricing & reimbursement panel coming up. Fun! Stay tuned
Evotec $EVT more than 4000 biotechs in the world, less than 5% are profitable, while underlining $EVT is profitable (though $EVT biz model is not the one of these 4000 bioechs) #Jefferies17
$CLLS plan for UCARTCS1 #Jefferies17
A.Choulika $CLLS $ALCLS Q: how is the AML patient going? A: not disclosing data, last we did stock fell (however they already disclosed she left hospital and went to her son’s wedding...) #Jefferies17
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