Top Tweets for #missingheritability
Kicking of my #eshg2024 with a talk on an unexplained case with megalencephaly and special dysmorphology, despite extensive genetic workup. #missingheritability in #genetics
More talks of @Erasmusgenetica of #rotterdam to come in #berlin!

The @CNRS highlights our recent @GenomeBiology paper that provides the first full* epistatic maps with gene resolution. We retrieve a good part of #missingheritability #GWAS
*full= no variable selection based on the signal.
Now available through here -> https://t.co/ejFffrAtnP
#ResultatScientifique🔎| Une méthode pour pouvoir travailler sur les combinaisons de variants génétiques propres à un trait de caractère
🤝 @CNRS @CNRS_OccitaniE @INRAE_OC_MPL @umontpellier
✍️ @GabKrouk
📕 @GenomeBiology | https://t.co/0q9w1m4cHs
https://t.co/ZSPCiue7W7
Thanks to @RajRamesar at #CapeTown university for virtually hosting me today for a seminar on our quest to solve #missingheritability in #neurogenetic #disorders. Looking forward to some future collaborations!
@eshgsociety @ICHG2023 @ErasmusMC @Erasmusgenetica

This and other #functionalgenomics findings from our lab has created a large atlas of regulatory elements driving human brain development, of which mutations might cause human disease. We are now using this atlas in WGS analysis
#missingheritability #raredisease #bioinformatics
The missing link between genetic association and regulatory function @eLife
https://t.co/vgPKc2j69j
#GWAS #eQTL #enhancers #GeneRegulation
A long-held assumption re: "#missingheritability" largely fails to hold water; a "#missingregulation" model attempts to address this.

Tomorrow (Saturday: 10h30) at #PAG30 I will present our new ultrafast #GWAS to study full epistatic maps (>60 billion interactions) and retrieve a good part of #missingheritability! And yes it is in the nitrogen session !
Location :
Pacific F-G (2nd Floor)

Finally we**** evaluate the #missingheritability that this epistatic signal (2D GWAS) retrieves and show that we almost double it for many phenotypes we studied (mainly nutrient content of plant leaves). This signal is used to improve phenotype predictions using #MachineLearning.

Coming up at 1115 in hall F1 at #ESHG2022 another talk of our lab from Eva Medico @evamedico96 about the active enhancer landscape in neural stem cells identified by ChIP STARR seq & zebrafish validation.
#enhancer #missingheritability #brain @Erasmusgenetica @ErasmusMC

Graph pangenome captures missing heritability and empowers tomato breeding. #GraphPangenome #MissingHeritability #TomatoBreading
https://t.co/rpYvLOLz22 @Nature
Deze terugbetaling van gentherapie stimuleert ons om ook bij ‘onopgehelderde’ patiënten met een #zeldzameziekte op zoek te gaan naar de ontbrekende genetische oorzaken #missingheritability die doelwitten kunnen zijn voor #gentherapie
#GWAS で報告された遺伝形質関連ローサイはすでに数万。しかし、そのシグナルで解読された重要な遺伝形質は皆無。立ちはだかる“#missingheritability”問題の次の鍵は、リピートの中(#VNTRs)に隠されている?UKBiobankからの有力データも:Science Perspective。
https://t.co/SaNej6U1bv
「#身長は遺伝するか」。遺伝学最大問題の一つに最大ゲノム解析による回答。全世界2万人の #WGS データで、従前の研究の残した20%の「#missingheritability」が少なくとも欧系人では、遺伝子レベルに帰せられる、と。Garvan のMacArthur :「 a genuine landmark」。
https://t.co/xYrlDYbkuY
@rplenge @ZaminIqbal We covered this #MissingHeritability paper recently in the podcast https://t.co/Uk9FnaneKd and I did an episode of the videocast https://t.co/BklnyctDdn . I hope people enjoy these!
@fdesouza More articles citing the work on #MissingHeritability from recent paper. We covered this in recent episodes of the #CambridgeGenomics podcast https://t.co/Uk9FnaneKd and the videocast #TheOmicsCast https://t.co/BklnyctDdn
Fantastic deep dive by @AlexTISYoung into the #MissingHeritability conundrum and new work addressing it. #QuantitativeGenetics #GWAS
Really informative interview on @insitome Insight podcast too :-)
https://t.co/V4HkHOwyh6

Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
and I have been saying this from day one :) unless we decipher genetic diversity in India, population scale #GeneticStudies won't bring out much and same with finding all Human #rarediseases. #missingHeritability #India #jammukashmir
Large-scale genetic studies still draw mostly on data from people of European descent—and that’s bad for everyone. https://t.co/5TRbXUEQi6
@lucienchardon1 @sentientist #missingheritability is like geographers naming discovery of America "missing earth" & declaring the rest ether
New study undercuts #GWAS claim of #MissingHeritability for common diseases; says shared enviro factors > #genetics.
https://t.co/YnQ8nif740
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