#molevol - Twitter Hashtag

about 5 years ago

Interesting thought: I guess it is not *guaranteed* to work, as mutational sweeps are interrogating a space that hasn't been validated by natural selection. #Alphafold2 #MolEvol

Ewan Birney @ewanbirney

about 5 years ago

A reminder for bioinformaticians - AlphaFold works off the *real* multiple alignment, created by evolution. Flipping an amino acid in the target protein to model a mutation will not work in AlphaFold. Please don't do it. Please dont write papers about how it doesn't work.

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Albert Vilella @AlbertVilella

over 6 years ago

Notice ORF10 at the very end (bottom left): can an ORF remain in such small viruses and not have a function? I presume negative selection is strong in this context? #molevol

Philippe Le Mercier, ViralZone @ViralZone

over 6 years ago

Annotating the #nCoV proteome. Spike has many variations in the bulk head of the protein. Compared to #SARS it lacks NS8a and b, but got a very different ns8 similar to many bats CoV. Also seems to encode for ORF14 found in bats CoV. The ORF10 from RefSeq is still hypothetical.

ViralZone's tweet photo. Annotating the #nCoV proteome. Spike has many variations in the bulk head of the protein. Compared to #SARS it lacks NS8a and b, but got a very different ns8 similar to many bats CoV. Also seems to encode for ORF14 found in bats CoV. The ORF10 from RefSeq is still hypothetical. https://t.co/jr1CCkbkqW

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Peter Mulhair @PeterMulhair

almost 9 years ago

Lab discussions of today: General consensus agrees that we trust @qikipedia facts more than high impact scientific publication journals #molevol #skepticalscientists

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