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🌸Acute Phosphate Nephropathy (3/n)
🔥Biopsy performed <3wk of exposure
👉Acute tubular degenerative changes(~ATN)+Interstitial edema
🔥Biopsy performed >3wk of exposure
👉Chronicity(IFTA)
🔥Hallmark- Tubular CaPh deposit
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🌸Acute Phosphate Nephropathy (2/n)
"Acute Nephrocalcinosis"
🔘Diagnostic criteria
♦️AKI
♦️H/O OSP exposure
♦️Biopsy- acute/chronic TI + abundant CaPh deposit
♦️No e/o HyperCal
♦️No other significant inj pattern
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🌸Acute Phosphate Nephropathy (1/n)
🔥Underrecognized
⚡OSP bowel purgatives
⚡Injury may take weeks after exposure to occur‼️
⚡Risk factors-
♦️Age>60yrs
♦️Female
♦️GFR<60
♦️HTN
♦️ACEI/ARB
♦️Diuretics
♦️NSAIDs
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