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Great paper - “Multiple epidemiologic studies have reported a decreased risk of dementia when MHT [HRT] is taken in midlife, with one reporting a 26% decreased risk of dementia and another a 30% decreased risk of AD [Alzheimer’s Disease], although the recommended duration of therapy is conflicting, with the former recommending use only in midlife and the latter suggesting ten or more years of therapy for maximum benefit. One study suggests as much as a 65% risk reduction in AD if initiated between 50 and 63 years of age.” Many people do not realise that body identical HRT is very different from older types containing synthetic progestogens too. https://t.co/9EEy6Y5APS