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A 27-year-old G5P4 woman at 35 weeks 1 day gestation presented w/ preterm premature rupture of membranes. The pregnancy was complicated by consanguinity, w/ both parents being first cousins. Family hx was notable for a prior neonate who died 45 days after birth from an unspecified skin disorder; three other children were healthy. At birth, the neonate had thick, plate-like hyperkeratotic plaques separated by deep erythematous fissures, severe acral edema w/ constrictive bands causing claw-like deformities & distal dusky discoloration concerning for ischemia, & B/L upper/lower eyelid ectropion, eclabium, flattened nasal bridge, & absent eyelashes & eyebrows. What’s the diagnosis❓

Introducing the first session of the Diagnexia Asia-Pacific Pathology Webinar Series, delivered in collaboration with internationally recognised pathologist and medical educator Dr Tristan Rutland. First webinar – Friday, September 25 at 9:00 AM EDT | 2:00 PM BST | 8:00 PM GMT+7 (Vietnam) Join Dr Mahmut Akgul, distinguished genitourinary pathologist and Division Chief at Albany Medical Center, for Urothelial Carcinoma Subtypes. This free, expert-led session will explore urothelial carcinoma subtypes and provide practical insights to support diagnostic practice. Register here: https://t.co/9ULdvJQKNZ #Pathology #Diagnexia #Uropathology #PathologyEducation