Top Tweets for #physiboss
One more milestone for the #PhysiCell community: we’re thrilled to announce our latest publication in Briefings in Bioinformatics -
"Building Multiscale Models with #PhysiBoSS, an Agent-Based Modeling Tool" 🧬📊
Check out the full article here: https://t.co/zgqABXxjQn
(1/6)
To conclude, this tutorial shows that #PhysiBoSS modeling doesn't require C++ coding skills, and is now simpler thanks to #PhysiCell Studio (even for advanced users). We hope this work will help a larger community to get into the multiscale modeling world.
Finally, we show a complete rewrite of @MRuscone cancer invasion model, removing most of the C++ code, and replacing it with the new mapping system. A larger scale, real-world example of how to use the latest #PhysiBoSS functionalities!
Third example had to be an immune example, since this is the most important application for #PhysiBoSS! We describe DCs, attracted by the CCL21 gradient toward the lymph node. There, they activate naive T-cells which differentiate in TH1,TH17 and Tregs (model from Corral et al.).
The second has been one of our goals with #PhysiBoSS for a long time: a signaling-controlled cell cycle model. Using the #Boolean model from Sizek et al., we link the cyclins to the transitions of the phases of the cell cycle. With that, we can reproduce the effect of mutants!
The first example is inspired by the TNF example of the original #PhysiBoSS. It shows how to quickly map a substrate concentration to a Boolean input, and an output to #PhysiCell's apoptosis and necrosis. It simulates long vs pulsatile treatment, necrotic core, and clonality!
Our #PhysiBoSS tutorial is finally available as a preprint: https://t.co/oYN5O3mRa3! Learn how to build #multiscale models with #Boolean intracellular signaling, without any code, using #PhysiCell Studio. Showing 3 simple examples, and an update of @MRuscone invasion model 👇
Not everyday you can have three different seminars on the same day that show fun uses of #PhysiBoSS: a lung infection simulation, a community benchmark and a study of the effect of geometries in drug treated tumours. https://t.co/FoFQESBY2A
Reading this while writing a tutorial on #PhysiBoSS focused in simplifying its usage comfort me that we are going in the right direction😀
"creating usable tools is a crucial step in the scientific process, with exceptional return on investment"
A must read for #compbio people !
Our essay in Nat Cell Bio:
"Bringing computation to biology by bridging the last mile"
We argue to shift resources/rewards towards creating user-friendly software to bridge computation and biology-it yields huge returns!
@shantanuXsingh
Free author link: https://t.co/B0H1v29SBI
We are very proud to be part #CERTAINTY, where we will build mechanistic models of population dynamics using #UpMaBoSS and #PhysiBoSS. Looking forward to work with such a great team in building #VirtualTwin for CAR-T therapy !
#FraunhoferIZI launches #CERTAINTY with partners, pioneering #VirtualTwin for personalised cancer care. Focused on multiple myeloma, backed by €10M EU, this collaboration is set to transform CAR-T therapy & precision medicine.
👉 https://t.co/qncSqv4Vtu
#InnovativeOncology
Webinar 🧐"Multiscale Model of Different Modes of Invasion: a PhysiBoSS Application"
@MRuscone from @institut_curie presents a 3D model of cancer cell invasion
📅 Nov 07 | ⏰ 15-16h CET
🔗https://t.co/zy8U77givv
#cellmigration #extracellularmatrix #PhysiBoSS
Join the upcoming PerMedCoE webinar: Multiscale model of the different modes of invasion: a #PhysiBoSS application by @MRuscone from the @institut_curie
👉 https://t.co/VMXR3CPm0q
#bioinformatics #machinelearning #mathematicalmodelling #agentbasedmodelling
This model was developed using PhysiCell Studio, a GUI developed by @rheiland which will forever change how we build #PhysiCell models ! This includes support for #PhysiBoSS, with automatic mapping between PhysiCell signals/behaviours and MaBoSS nodes, and specific visualization
Thanks to the organizers for inviting me to present my latest work on #PhysiBoSS ! I showed some initial work on creating cell-line specific models of tumor growth, and discussed how we can predict treatment response and extend it to patient data. More to come !
Together with @ArnauMontagud and @Annaerial, Laurence Calzone from @institut_curie organized the great workshop on mechanistic and AI digital twins in personalized medicine at @BC2Conference ! Many great presentations and thoughtful discussions, thanks to all the participants 🙏
📢 Our paper is out! Explore cancer cell invasion mechanisms in our latest publication on #Bioinformatics.🧬 Using #PhysiBoSS, we simulated cancer cells in an extracellular matrix, capturing gene interactions and physical dynamics! https://t.co/cgAp1z8WWf
Fillin' up 🔋 at the #SummerSchool today's agenda:
➡️ Simulation of multicellular systems by @ArnauMontagud , @miguep11 and @TDiniaco of @BSC_CNS
➡️ Hands-on: Multiscale modelling of cell systems with #PhysiCell and #PhysiBoSS
➡️Project work in groups
➡️ Poster Sessions
16th of March will be the last day to register to this great summer school "From pathway modelling to cell-level simulation"!
Join me and other experts on the field to learn about #PhysiCell, #MaBoSS, and #PhysiBoSS in Spain this June!
https://t.co/MfsO5nwY8z
@CicelyKrystyna @MathCancer @RMCrossley @YuanYin_Becca @gijsjekoenderi1 @PfistererKarin @robynshutt @MRuscone @roeland_merks @tisrenk I was able to take a picture of @MRuscone presenting his #PhysiBoSS model of invasion ! Thanks again @CicelyKrystyna and @robynshutt for organizing this great workshop #CECAMECM23 !
Don't forget to register to our Summer School ! A great opportunity to learn how to build biological models with some great tools ! Even better, in the beautiful country side of Barcelona :)
#MaBoSS #PhysiCell #PhysiBoSS #COBREXA #CellNOpt #CARNIVAL
📢Countdown to the registration deadline has started. Don't miss the opportunity to join us in Seva for the PerMedCoE Summer School and gain hands-on experience with our modelling tools while enjoying the stunning mountain views
#HPC #BiomedicalWorkflows
🔗https://t.co/wNkZGpqeL8
Thanks a lot for the great opportunity to present our tools to the students @Annaerial and @Hall_b_a ! This has been a wonderful course 😀 #maboss #physiboss #systemsbiology #complexdiseases #wellcometrustcampus
Moving forward with exciting talks from @vincentnoel72 and #LaurenceCalzone from @SysBioCurie on cancer systems biology and MaBoSS environment. Great vibes and state of the art training in the Hinxton Campus.
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