#polargo - Twitter Hashtag

16 days ago

🚨 POLARGO may have changed the salvage conversation in transplant-ineligible R/R DLBCL. Not with a bispecific. Not with CAR-T. But by simply adding polatuzumab to R-GemOx. 👀 #POLARGO | JCO 2026 Patients with transplant-ineligible R/R DLBCL were randomized to: 🔹 Pola-R-GemOx vs 🔹 R-GemOx What changed? ✅ OS improved 19.5 vs 12.5 months HR 0.60, p=0.0017 ✅ PFS improved 7.4 vs 2.7 months HR 0.37, p<0.0001 ✅ CR rate doubled 40.3% vs 19.0% ✅ ORR doubled 52.7% vs 24.6% Why this matters This is not just a response-rate story. This is a true overall survival benefit in a setting where many patients are older, frail, or not candidates for transplant/CAR-T. But toxicity is the catch ⚠️ Peripheral neuropathy: 57% vs 28.8% ⚠️ Grade 5 AEs: 11.7% vs 4.0% ⚠️ Excess fatal AEs were largely infection-related, including COVID. My take For transplant-ineligible R/R DLBCL, Pola-R-GemOx looks like a real new option, especially where access to CAR-T/bispecifics is limited. The debate now is not whether it works. It’s where it fits against bispecifics, CAR-T, and pola-BR in 2026 practice. Would you use Pola-R-GemOx as your default salvage backbone in transplant-ineligible R/R DLBCL? #lymsm #hematology #oncology @JCO_ASCO @oncoalert

DrRishabhOnco's tweet photo. 🚨 POLARGO may have changed the salvage conversation in transplant-ineligible R/R DLBCL.

Not with a bispecific.
Not with CAR-T.
But by simply adding polatuzumab to R-GemOx. 👀

#POLARGO | JCO 2026

Patients with transplant-ineligible R/R DLBCL were randomized to:

🔹 Pola-R-GemOx
vs
🔹 R-GemOx

What changed?

✅ OS improved
19.5 vs 12.5 months
HR 0.60, p=0.0017

✅ PFS improved
7.4 vs 2.7 months
HR 0.37, p<0.0001

✅ CR rate doubled
40.3% vs 19.0%

✅ ORR doubled
52.7% vs 24.6%

Why this matters

This is not just a response-rate story.
This is a true overall survival benefit in a setting where many patients are older, frail, or not candidates for transplant/CAR-T.

But toxicity is the catch

⚠️ Peripheral neuropathy: 57% vs 28.8%
⚠️ Grade 5 AEs: 11.7% vs 4.0%
⚠️ Excess fatal AEs were largely infection-related, including COVID.

My take

For transplant-ineligible R/R DLBCL, Pola-R-GemOx looks like a real new option, especially where access to CAR-T/bispecifics is limited.

The debate now is not whether it works.
It’s where it fits against bispecifics, CAR-T, and pola-BR in 2026 practice.

Would you use Pola-R-GemOx as your default salvage backbone in transplant-ineligible R/R DLBCL?

#lymsm #hematology #oncology @JCO_ASCO @oncoalert

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nora @NoraSeabass

7 months ago

REED UPで穴開けた再生リードで山下達郎さんのRIDE ON TIMEを吹いてみた。下手だけど、少しリバーブ掛かるとヴェノーヴァの音が気持ち良い！POLAR GOのセッティングも色々試していきましょう。 #ヴェノーヴァ #venova #カジュアル管楽器　#POLARGO

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dxzo wish @DxzoWish

11 months ago

まいにゅーぎあー！オーディオインターフェースは元々持ってるんですがお外でiPhoneで弾き語り録音したりできたら楽しいかなぁとiPhone用に購入しました！内蔵マイクを使った弾き語りを録音出来次第upするので聴いてもらえたらうれしいなぁと！ #Blackster #POLARGO

DxzoWish's tweet photo. まいにゅーぎあー！
オーディオインターフェースは元々持ってるんですがお外でiPhoneで弾き語り録音したりできたら楽しいかなぁとiPhone用に購入しました！

内蔵マイクを使った弾き語りを録音出来次第upするので聴いてもらえたらうれしいなぁと！

#Blackster
#POLARGO https://t.co/HpiGBUCa4g

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BIGBOSS広島 @hiroshimaBB

11 months ago

#Dr住吉です!! 話題の新製品✨ #Blackstar POLAR GO チェックしてみました👀👀 スマートフォン内蔵マイクを遥かに!! 凌駕するステレオマイクロホンを装備したオーディオインターフェイス!! しかもこのサイズ感、すご🔥🔥 サウンド、動画はこちら↓🎥 https://t.co/D4ffNG9KJ6 #POLARGO #ギター