Top Tweets for #quick_notes_LP
GENE THERAPY FUTURE DIRECTIONS: A SIMPLE VISUAL FRAMEWORK TO UNDERSTAND HOW TO CAPTURE VALUE/ This quick_note highlights some of the principal trends in the sector affecting future value. It was co-authored with @gemmagnrt #quick_notes_LP
@love_nowww Hi, you can read this thread from @pareras here: https://t.co/bv8MTOqItU #quick_notes_LP
LAUNCHING A BIOTECH STARTUP/ Some advice for scientists willing to become entrepreneurs, here are six things you should think carefully before embarking on your journey... (OPENING THREAD: some slides I used in a lecture @EU_Commission last month) #quick_notes_LP
ONCOLOGY FUTURE DIRECTIONS/ Here's a map of some of the most promising research fields in oncology today, plus a video —below— with some advice for scientists willing to become entrepreneurs (from a debate on the future of oncology and how to make it happen) #quick_notes_LP
CANCER BIOLOGY OPEN PROBLEMS/ One of the most important things every investor looks for in a startup is a good problem to solve... Unanswered questions always signal what's next. Here's a map of some of the most pressing questions in the oncology field today. #quick_notes_LP
RNA THERAPIES/ RNAs are very active players in cell biology... they carry instructions for making proteins, turn genes on and off, aid chemical reactions, slice and dice other RNAs, and build proteins. Here's a simple map to understand how can we use them as drugs #quick_notes_LP
COVID19 VACCINES LANDSCAPE/ a different view on phase II - III #COVID_19 vaccines, organized on a spectrum ranging from less innovative technology (older, slower, less uncertain development) to more leading edge approaches (faster, riskier) #quick_notes_LP
THE ART OF CHOOSING INDICATIONS/ you already have a lead candidate for a first specific indication, here’s a simplified conceptual map on how VCs think to choose the most interesting new indications (pipeline strategy) #venture_capital #quick_notes_LP
INVESTMENTS IN THE TIMES OF #COVID19/ Every crisis brings risks and opportunities to the table... here's a mind map on how SARS-CoV-2 can impact the activities and value chain of the life sciences VC industry #quick_notes_LP
ORPHAN DRUGS/ Most rare diseases still lack approved treatments despite major advances in the knowledge of their molecular basis. Here’s a map of the different therapeutic modalities plus an update on some of the most interesting new developments in each field #quick_notes_LP
SARS-CoV-2/ The vaccine effort for #COVID19 is unprecedented in scale & speed. To get it right and fast we need new tools and strategies including DNA/RNA vaccines, virus-like particles, T-cell inducing peptides & viral vectors... here's a map of the leading edge #quick_notes_LP
ANATOMY OF CRISPR/ By delivering Cas9 nuclease + gRNA into a cell, the cell's genome can be cut at a desired location allowing genes to be removed or new ones added... thousands of rare diseases could benefit, here's a map to understand what it does & basic parts #quick_notes_LP
GENE THERAPY/ A map to understand the different types of g͟e͟n͟e͟ ͟t͟h͟e͟r͟a͟p͟y͟ —transfer of genetic material to a patient— & g͟e͟n͟e͟ ͟e͟d͟i͟t͟i͟n͟g͟ —correction of a mutation in situ—, and how we deliver the genetic payload or correction into the right cells #quick_notes_LP
ANTIVIRALS/ sadly, the emergence of the SARS-CoV-2 pandemic (#COVID19) reminds us of the important clinical need to find good broad-spectrum antiviral agents... here's a map with some of the most promising lines of research to fight viruses #quick_notes_LP
THE MATHS BEHIND AN EPIDEMIC/ maths can model infectious diseases to predict the outcome of an epidemic (i.e. #COVID2019) and help public health interventions... here's a brief overview of the most basic things that matter to understand infectious disease dynamics #quick_notes_LP
CELL & GENE THERAPIES/ Here's a short-list of some basic things we need to have in mind when designing the clinical trial of an advanced therapy... remember we're using (or modifying) cells, not small molecules or biologics #quick_notes_LP
THE FUTURE OF ANTIBIOTICS/ Multi drug resistances (MDR) are an important challenge... without new alternatives to antibiotics all future scenarios predict terrible consequences. Scientists are working hard to develop them, here's a map of the leading edge #quick_notes_LP
BOARDS 101 FOR BIOTECH ENTREPRENEURS/ founders are thrown into a board without much knowledge of how it works... can I be fired being the founder? how will the board help? what are the formal/informal roles of a board? here's a very basic overview and some advice #quick_notes_LP
CELL & GENE THERAPIES/ hundreds of trials are underway with some major therapeutic breakthroughs... Will their use become ubiquitous? Or will its adoption be slow? Here's a map of the things that matter when discussing CMC issues to develop an advanced therapy #quick_notes_LP
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