#tom70 - Twitter Hashtag

2 days ago

SARS-CoV-2 has another mitochondrial “trick”—and researchers are trying to block it. ➡️ The viral protein #ORF9b binds to #TOM70, a #mitochondrial protein that helps trigger the cell’s type-I interferon antiviral response. By interfering with this pathway, ORF9b can help the virus dampen the host’s early immune defence. 1/

vipintukur's tweet photo. SARS-CoV-2 has another mitochondrial “trick”—and researchers are trying to block it.

➡️ The viral protein #ORF9b binds to #TOM70, a #mitochondrial protein that helps trigger the cell’s type-I interferon antiviral response.

By interfering with this pathway, ORF9b can help the virus dampen the host’s early immune defence. 1/

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Pablo Pulido @PabloPulidoPQC

almost 6 years ago

This is a very suggestive concept! #Chaperone interaction of #Tom70 might be more relevant for #stress tolerance than its #ProteinImport. #ProteinQualityControl #PQC #Proteostasis #Mitochondria

Johannes Herrmann @Herrmann_lab

about 6 years ago

Excited to share our new study: In vivo the mitochondrial Tom70 is predominantly a stress-protecting proteostasis factor for the cytosol rather than an import receptor for carriers! Great collaboration w Schuldiner, Rapaport, Steinmetz and Storchova labs! https://t.co/fGyZexkEwJ