Literally the only answer to this is in modern times is West Virginia losing 13-9 to Pitt in the last regular season game of 2007
That was the one shot they were ever going to get at a national championship and they pissed it away against a 4 TD underdog who was their arch rival
The Kick 6 is a stupid nomination. Alabama had won 3 of 4 national titles and was clearly going to win more. It sucked but it didn’t alter the trajectory of the program
But the 2007 Backyard Brawl was IT for West Virginia