NeuroScienceAdvance

[NeuroScienceAdvance @hlpan61]

A new study published in J Neurosci reveals the link between #HIV and #chronic #pain. https://t.co/fUF15H2xPc

[NeuroScienceAdvance @hlpan61]

A new JCI publication reveals the new molecular mechanisms of nerve pain and the therapeutic actions of gabapentinoids. https://t.co/tXIq274GKw

[NeuroScienceAdvance @hlpan61]

A new study published in The Journal of Clinical Investigation: Spinal α2δ-1 induces GluA3 degradation to regulate assembly of calcium-permeable AMPA receptors and pain hypersensitivity. https://t.co/tXIq275eA4

[NeuroScienceAdvance @hlpan61]

This study uncovers a noncanonical role of neuronal #LRRC8A in regulating #pain chronicity by restricting the synaptic expression of #NMDA #receptors in the spinal cord. See a new publication in Sci Transl Med https://t.co/oPZKabumsg

[NeuroScienceAdvance @hlpan61]

LRRC8A constitutively inhibits pain hypersensitivity in rodent models by restraining NMDA receptor activity at spinal cord synapses. https://t.co/oPZKabumsg

[NeuroScienceAdvance @hlpan61]

A new study published in Science Translational Medicine on limiting NMDA receptor-mediated pain chronicity by LRRC8A protein. https://t.co/oPZKabumsg

[NeuroScienceAdvance @hlpan61]

A new #JNeurosci study shows how #GABA and #glycine inhibition control #pain chronicity and #NMDA #receptor activity in a cell- and synapse-specific manner. https://t.co/bB9obzryS6

[NeuroScienceAdvance @hlpan61]

Tonic GABA and Glycine Inhibition Control Pain Hypersensitivity via Limiting α2δ-1– and mGluR5–Dependent NMDA Receptor Activity at Primary Afferent–Excitatory Neuron Synapses. https://t.co/bB9obzryS6

[NeuroScienceAdvance @hlpan61]

Gαq signaling contributes to opioid-induced NMDA receptor hyperactivity at nociceptor central terminals by promoting mu-opioid receptor-mGluR5 cross-talk. https://t.co/k0TE7kje9c

[NeuroScienceAdvance @hlpan61]

How do opioid drugs induce opioid paradox? https://t.co/7saO4IPr6N

[NeuroScienceAdvance @hlpan61]

A new study published in #Science #Signaling demonstrating that #Gαq in #pain-sensing neurons shifts #opioid #analgesia to #NMDA receptor–driven tolerance and hyperalgesia. @scisignal

[NeuroScienceAdvance @hlpan61]

A Science Signaling study shows that the stimulatory G protein, Gq, switches opioid actions from analgesia to hyperalgesia: https://t.co/7saO4IPr6N

[NeuroScienceAdvance @hlpan61]

A Science Signaling study shows that the stimulatory G protein, Gq, switches opioid actions from analgesia to hyperalgesia: https://t.co/7saO4IPr6N

[NeuroScienceAdvance @hlpan61]

How do opioid drugs induce opioid paradox? https://t.co/7saO4IPr6N

[NeuroScienceAdvance @hlpan61]

A new study published in #Science #Signaling demonstrating that #Gαq in #pain-sensing neurons shifts #opioid #analgesia to #NMDA receptor–driven tolerance and hyperalgesia. @scisignal

[NeuroScienceAdvance @hlpan61]

A new #Circulation #Research publication has identified reduced #brain #calcineurin activity as the potential cause of #idiopathic #hypertension. https://t.co/4lQo4MPpG7

[NeuroScienceAdvance @hlpan61]

A new #Circulation #Research study shows that essential (primary) #hypertension, or hypertension with no identifiable cause, results from diminished #calcineurin activity in the #brain. https://t.co/fCAWRwBecZ

[NeuroScienceAdvance @hlpan61]

A comprehensive review of the #alpha2delta-1 protein and #gabapentinoid drug actions in #chronic neuropathic #pain. https://t.co/ezvFGRr24z

[NeuroScienceAdvance @hlpan61]

How does histone methyltransferase G9a regulates the expression of TRPA1 and TRPV1 in inflammation-induced pain? https://t.co/yBcM1L6cwF

[NeuroScienceAdvance @hlpan61]

A new study published in JNeurosci# shows the epigenetic# mechanism of persistent inflammatory# pain#. https://t.co/yBcM1L6cwF