Philip Howe Lab

Chair of Department of Biochemistry and Molecular Biology at MUSC. TGF-beta signaling and EMT. Tweets from the lab @MUSC_health @muschollings

[Philip Howe Lab @howe_lab]

In this thread, we’d like to share with you our first publication of 2022, titled “The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.” Published in @oncogenejournal (1/X)

[Oncogene Journal @oncogenejournal]

In their latest #OpenAccess report, @howe_lab & co-workers identify a novel function for the ubiquitin E3 ligase ARIH1 in #EMT induction and cancer progression.

ARIH1 silencing in #BreastCancer cells significantly attenuates tumour formation!

🔬 https://t.co/x8wuLxMalG

[Philip Howe Lab @howe_lab]

🚨 Apply to this Postdoctoral fellowship 🚨

Excited to share our Call for Applications for our NCI T32 Postdoctoral Fellowship in Oncogenic Signaling at @muschollings. Details are at this link:
https://t.co/Ii1BtVJi8Z

[Mammary Cell News @MammaryCell]

Medical University of South Carolina (@MUSChealth) researchers demonstrate a delayed ⌚ induction of EMT and reduced invasion in #MammaryEpithelialCells silenced for ARIH1.

@oncogenejournal | 📑 https://t.co/AQgIWDKylu

[Philip Howe Lab @howe_lab]

@AntoniKourtidis @oncogenejournal Thank you Antonis!

[Philip Howe Lab @howe_lab]

In this thread, we’d like to share with you our first publication of 2022, titled “The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.” Published in @oncogenejournal (1/X)

[Oncogene Journal @oncogenejournal]

In their latest #OpenAccess report, @howe_lab & co-workers identify a novel function for the ubiquitin E3 ligase ARIH1 in #EMT induction and cancer progression.

ARIH1 silencing in #BreastCancer cells significantly attenuates tumour formation!

🔬 https://t.co/x8wuLxMalG

[Philip Howe Lab @howe_lab]

After these in vitro studies, we tested the function of ARIH1 in tumor initiation and metastasis using xenograft models, check out our exciting data in the paper! (6/6)

[Philip Howe Lab @howe_lab]

Next, we tested whether ARIH1 overexpression(OE) promotes epithelial cell plasticity. ARIH1 OE effected the expression of EMT markers and increased cancer stemness markers ALDH1A1, SOX2, and NANOG. We also found that ARIH1 OE increased invasiveness of these cells (5/X)

[Philip Howe Lab @howe_lab]

Hi Twitter! This is the first tweet from The Howe Lab @muschealth & @muschollings! We are a lab that studies the interface of metastasis, RNA binding proteins, TGFβ signaling and the Epithelial to Mesenchymal transition (EMT).