Joaquín Ibarguren

[Mariano Angarolla @mariano_anga]

Franco 2027 🙌🇦🇷

[Joaquín Ibarguren @ibargujo]

😍😍😍

[Federico Gomez @Fede3Gomezz]

los días pasan y yo me quedé acá siendo el más feliz del mundo

[Dios @diostuitero]

39 años.

[Stella Artrosis. @yosiome]

Cuanto lo siento Egipto.

[La Página Millonaria @RiverLPM]

NO TE RETIRES NUNCA, GENIO!!

[Iñigo San Millán @doctorinigo]

Gracias Mario Redondo por invitarme a este podcast donde hablamos del metabolismo del cancer y de la actividad física como terapia oncologica.

https://t.co/O1z0BPZjqz

[Iñigo San Millán @doctorinigo]

Lactate in Exercise vs Cancer: Same Molecule, Opposite Meaning

Lactate is not a waste product. It’s a central player in both peak human performance and tumor progression. However, the context defines its role.

🚴 In exercise, lactate is:
-A regulated byproduct of glycolysis during high energy demand.
-Mainly shuttled to slow twitch fibers and other tissues (heart, brain) as a preferred fuel
-A signal for mitochondrial biogenesis, improved metabolic flexibility and training adaptation
-Cleared efficiently via the lactate shuttle and mitochondrial lactate oxidation complex (mLOC). When exercise ceases, so does muscle lactate accumulation

🧪 In cancer, lactate is:
-The goal, not a byproduct (“lactagenesis hypothesis”, San-Millan and Brooks, 2016 https://t.co/yViJoMQV8u)
-Tumors intentionally upregulate glycolysis (Warburg Effect) to generate lactate even in oxygen abundance.
-Lactate accumulates in the tumor microenvironment, promoting:
*Angiogenesis (via HIF-1α)
*Immune evasion (T cell suppression)
*Invasion and metastasis
*Gene expression and Epigenetic remodeling (histone lactylation)

🏃‍♂️ In athletes, lactate is a both a key regulator and marker of performance as well as adaptation.
🧬 In cancer, lactate is both a key regulator and marker of aggression as well as poor prognosis.

Same molecule. Different fate. Opposite implications.

#LactateScience
#CancerMetabolism
#MetabolicReprogramming
#ExercisePhysiology
#MetabolicFlexibility
#WarburgEffect

[Juan Cruz Alvarez @Juanito77ok]

Hold positions…

[Iñigo San Millán @doctorinigo]

🧠On Alzheimer’s as a metabolic disease 👇
🧵
1) The more we learn about brain metabolism, the clearer it becomes: Alzheimer’s is not primarily a disease of amyloid plaques. It is a metabolic disease.
Let’s talk about what that means, and why the current paradigm must change:

[Iñigo San Millán @doctorinigo]

Lactate in Exercise vs Cancer: Same Molecule, Opposite Meaning

Lactate is not a waste product. It’s a central player in both peak human performance and tumor progression. However, the context defines its role.

🧬 In exercise, lactate is:
-A regulated byproduct of glycolysis during high energy demand
-Rapidly shuttled to slow twitch fibers and other tissues (heart, brain) as a preferred fuel
-A signal for mitochondrial biogenesis, improved metabolic flexibility, and training adaptation
-Cleared efficiently via the lactate shuttle and mitochondrial lactate oxidation complex (mLOC). When exercise ceases, so does muscle lactate accumulation

⚠️ In cancer, lactate is:
-The goal, not a byproduct (“lactagenesis hypothesis”)
-Tumors intentionally upregulate glycolysis (Warburg Effect) to generate lactate even in oxygen abundance.
-Lactate accumulates in the tumor microenvironment, promoting:
*Angiogenesis (via HIF-1α)
*Immune evasion (T cell suppression)
*Invasion and metastasis
*Gene expression and Epigenetic remodeling (histone lactylation)

🏃‍♂️ In athletes, lactate is a marker of performance and adaptation.
🧬 In cancer, lactate is a marker of aggression and poor prognosis.

Same molecule. Different fate. Opposite implications.

#LactateScience
#CancerMetabolism
#MetabolicReprogramming
#ExercisePhysiology
#MetabolicFlexibility
#WarburgEffect

[@UAE-TeamEmirates @TeamEmiratesUAE]

Smiling in yellow 💛 #TDF2025

#WeAreUAE

[Iñigo San Millán @doctorinigo]

🔬 CANCER'S ENERGY CRISIS: TIME TO TARGET LACTATE!

For over a century, cancer’s metabolic hallmark has been clear: high glycolytic rates even in the presence of oxygen. Otto Warburg identified this paradox, which we now understand as a powerful adaptive mechanism, not a flaw.

👇Here’s a summary of how lactate lies at the center of cancer metabolism, signaling, and therapy 🧵

[Manu Ginobili @manuginobili]

Argentinos: no naturalicemos lo de este gigante! Lo que hace en la cancha y lo que le da a su equipo es extraordinario. Un fuera de serie! A reconocerlo y celebrarlo. 🙌🇦🇷

[Iñigo San Millán @doctorinigo]

One of the biggest barriers in sports performance is objectivity.
During the good times, everything looks great. However, during the bad times, objectivity is the first thing that goes…What was bright before, overnight can be very dark…

An advice I always give to those entering sports performance in any of its modalities: collect data, measure parameters and communicate constantly.

[Joaquín Ibarguren @ibargujo]

I voted for F. COLAPINTO as #F1DriveroftheDay. Make your vote here: https://t.co/8tn6GuVEbh https://t.co/NFjqTrCiil

[Manu Ginobili @manuginobili]

🇦🇷Hace 20 años empezaba de esta manera nuestro sueño olímpico. Inolvidable!
🇺🇲Surreal way to start your Olympic journey!! Unforgettable.

[Joaquín Ibarguren @ibargujo]

Yo aguantando...

[Dilo con dibujos @dilocondibujos_]

Soy 🥰🥰🥰

[Joaquín Ibarguren @ibargujo]

https://t.co/1lpS4hZWf7

[Joaquín Ibarguren @ibargujo]

Cáncer, Lactato, Mitocondria | Iñigo San Millán | Sango #shorts https://t.co/uLOe0Wj49B a través de @YouTube

[Joaquín Ibarguren @ibargujo]

TOOOOODO tan fácil hace😍😍😍😍

[Velon CC @VelonCC]

An interesting mix of kit 😅

Pogačar was one of the only riders on a rain affected Stage 16 to finish with no gloves and bare arms 👀

📸 Getty Images