Paul Belcher

A Scientist (chemistry and biophysics), gentleman, father, raconteur, modernist, biacore-ologist and the worlds best dressed biophysicist

[Paul Belcher @iceobar]

Regardless of the drug development stage, it is critical to have well-designed and qualified methods. If you use SPR and only read one paper this week, make it this one. It includes important considerations of assay development and optimization metrics. https://t.co/p6kh7lGjul

[Paul Belcher @iceobar]

SPR System Fact Or Fiction Series https://t.co/FZGiJnw42e

[Paul Belcher @iceobar]

Cytiva releases Biacore Intelligent Analysis™ - our innovative machine learning software that significantly reduces the manual, time-consuming steps of data curation and quality control in fragment screening applications by SPR https://t.co/lDOO6QeZSd

#machinelearning
#SPR

[Paul Belcher @iceobar]

Adoptive cell therapy (ACT) with tumor-specific T cells can promote durable regression of diverse cancers. Some really nice work (including #Biacore data) in this paper to understand T cell recognition of cancer #neoantigens at the atomic level.

https://t.co/5NbjCS0ut0

[Paul Belcher @iceobar]

Nice paper looking at screening and binding analysis of bioactive components from Radix Paeoniae Alba to find which are the source of its anti-inflammatory properties via TNF-R1. https://t.co/RjmctidIrT

[Paul Belcher @iceobar]

Super cool paper from AZ who set out to develop a biosensor-based method to facilitate the data deconvolution of complex #SPR sensorgrams by reducing the surface heterogeneity. https://t.co/pbYnALYAvg

[Paul Belcher @iceobar]

@modernista64 drain the swamp!!!

[Paul Belcher @iceobar]

Nice paper comparing various methods for the detection and measurement of botulinum toxins including an #SPR assay using #Biacore T200 system which specifically measured intact 19S neurotoxin. https://t.co/NGCBpJR47O

[Paul Belcher @iceobar]

😂

[Rob @thegallowboob]

its that time of the year again, don’t forget to hang your missile toads

[Paul Belcher @iceobar]

Nice paper from Rutgers University on a FBDD approach using Biacore 8K+ system to find inhibitors to Ricin, one of the most potent toxins known.
https://t.co/uzvXk7aJ0E

[Paul Belcher @iceobar]

Having caught lymes (and it ruined me for about a year) this is fantastic news.

[Genetic Engineering & Biotechnology News @GENbio]

Lyme Disease Vaccine Uses mRNA to Encode Tick Saliva Proteins

Lyme disease vaccine based on mRNA targets tick saliva proteins and induces tick resistance and prevents transmission of Lyme disease agent. Learn more: https://t.co/UhsC85H7mQ

[Paul Belcher @iceobar]

Cytiva's Paul Belcher on why transparent AI is critical for the biophysical data. https://t.co/cg3kaMnfh7

#machinelearning
#lifesciences
#AI

[Paul Belcher @iceobar]

#nerdlife

[Paul Belcher @iceobar]

Today I’m being a real

[Paul Belcher @iceobar]

Transparent machine learning — AI(d) to overcome inconsistencies in SPR data analysis, saving time and increase productivity in LMW discovery. https://t.co/CD7uXBT8Oz

[Paul Belcher @iceobar]

Join us for another fact or fiction where we discuss why the sensitivity of optical biosensors is important for not just smaller molecules but also for larger molecular entities including antibodies, and dimeric targets like membrane or signaling proteins. https://t.co/3yPEWxeh1N

[Paul Belcher @iceobar]

The ability to reverse or “flip” the assay format in #SPR assays is really useful in situations where one reagent might be in limited supply or just to confirm or verify binding. But do you get the same binding constants when you flip the assay?

https://t.co/aCWIJZr7K1

[Paul Belcher @iceobar]

Huge! 👏 https://t.co/7jTLXkRpU6

[Paul Belcher @iceobar]

Anyone else as excited for the new James Bond movie as I am??

[Paul Belcher @iceobar]

Can non-specific binding be subtracted out of data generated from optical biosensors like #SPR? Join us for another fact or fiction where we discuss #factorfiction

https://t.co/w0TAZlhr3c