Regardless of the drug development stage, it is critical to have well-designed and qualified methods. If you use SPR and only read one paper this week, make it this one. It includes important considerations of assay development and optimization metrics. https://t.co/p6kh7lGjul
Cytiva releases Biacore Intelligent Analysis™ - our innovative machine learning software that significantly reduces the manual, time-consuming steps of data curation and quality control in fragment screening applications by SPR https://t.co/lDOO6QeZSd
#machinelearning#SPR
Adoptive cell therapy (ACT) with tumor-specific T cells can promote durable regression of diverse cancers. Some really nice work (including #Biacore data) in this paper to understand T cell recognition of cancer #neoantigens at the atomic level.
https://t.co/5NbjCS0ut0
Nice paper looking at screening and binding analysis of bioactive components from Radix Paeoniae Alba to find which are the source of its anti-inflammatory properties via TNF-R1. https://t.co/RjmctidIrT
Super cool paper from AZ who set out to develop a biosensor-based method to facilitate the data deconvolution of complex #SPR sensorgrams by reducing the surface heterogeneity. https://t.co/pbYnALYAvg
Nice paper comparing various methods for the detection and measurement of botulinum toxins including an #SPR assay using #Biacore T200 system which specifically measured intact 19S neurotoxin. https://t.co/NGCBpJR47O
Nice paper from Rutgers University on a FBDD approach using Biacore 8K+ system to find inhibitors to Ricin, one of the most potent toxins known.
https://t.co/uzvXk7aJ0E
Transparent machine learning — AI(d) to overcome inconsistencies in SPR data analysis, saving time and increase productivity in LMW discovery. https://t.co/CD7uXBT8Oz
Join us for another fact or fiction where we discuss why the sensitivity of optical biosensors is important for not just smaller molecules but also for larger molecular entities including antibodies, and dimeric targets like membrane or signaling proteins. https://t.co/3yPEWxeh1N
The ability to reverse or “flip” the assay format in #SPR assays is really useful in situations where one reagent might be in limited supply or just to confirm or verify binding. But do you get the same binding constants when you flip the assay?
https://t.co/aCWIJZr7K1
Can non-specific binding be subtracted out of data generated from optical biosensors like #SPR? Join us for another fact or fiction where we discuss #factorfiction
https://t.co/w0TAZlhr3c