Ascorbate is its ionised (deprotonated) form, which predominates in the body at physiological pH. Ascorbate is the focus of new Vitamin C research #ccrdownunder
The preparation is important- Mark Plummer nicely outlining the importance of understanding what is studied in Vit C trials Ascorbic acid is the acidic, protonated form of Vit C (used in many trials and may explain the harm 1/2 #ccrdownunder#VITACCtrial
#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times https://t.co/LHZeWQLw7w #ccrdownunder@CritCareReviews
Co-Chief Investigators Brenda O'Neill and Danny McAuley share the results of the #iRehab trial after presenting at #CCRdownunder
Livestream -> https://t.co/yuW9S7tuif
@JAMA_current
What a bumper day at #CCRDownUnder - 3 @JAMA_current publications and a fabulous amount of discussion about trial design and the practical implications of the results.
Get ready for day 2!! https://t.co/N9AkZtrrcm
That's the end of Day 1 at #CCRDownUnder
3 Papers in @JAMAcurrent 🙏
ImmunoSep -> -> https://t.co/1xwKNLO3mI
editorial: https://t.co/fNcXfj7PEY
CLIP-II -> https://t.co/PyLKV9Sgag
ed: https://t.co/oyYpU18UYN
ACTiVE -> https://t.co/g5XDsIHRiS
ed https://t.co/FvDAlh6vfa
Among adults undergoing cardiac surgery at high risk of bleeding and platelet transfusion, cryopreserved platelets did not meet noninferiority for controlling postoperative bleeding and were less effective than liquid-stored platelets. #CCRdownunder https://t.co/PXBAuPE5GK
Congratulations to the trial team- Prof Michael Reade, PM Belinda Howe- great to see a @anzicsctg trial in lights again at #CCRDownUnder
Also congrats to @iculisah and Zhomart who led this economic review alongside the trial @anzicrc
Cryopreserved platelets can be stored for up to 2 yrs, compared to 7 days for liquid-stored platelets. This cost-effectiveness analysis found that cryopreserved platelets were costlier & less effective for managing bleeding in cardiac surgery.#CCRdownunder https://t.co/lZ9l8Dd73t
Cryopreserved platelets can be stored for up to 2 yrs, compared to 7 days for liquid-stored platelets. This cost-effectiveness analysis found that cryopreserved platelets were costlier & less effective for managing bleeding in cardiac surgery.#CCRdownunder https://t.co/lZ9l8Dd73t
A wonderful example of extensive PPIE in a trial, including trying to address aspects of diversity and ensure wide engagement in a complex intervention- look forward to the primary results publication
https://t.co/T8w69bWl8T
#irehabtrial#CCRDownUnder
Missing QOL data from drop-outs should really be imputed for the primary analysis (because they are not missing a random). Primary analysis should be on the ITT population.
#CCRdownunder25#iRehabtrial