Igor Morr

MD. MSc. Cardiologist. Assoc Professor . Clinical Research. FACC. FSIAC Tropical Cardiology . Scientific Journalist

[Igor Morr @igormorr]

Brain Changes Linked With Speech-in-Noise Impairment https://t.co/AYtB0J2YGe

[Igor Morr @igormorr]

Dawn of Heart Muscle Patches to Address Lost Myocardium in Heart Failure https://t.co/2fh8n39Oon

[Igor Morr @igormorr]

So Far, So Good for PCSK9-Targeting Gene Therapy in Hypercholesterolemia https://t.co/8lm17bLz2J

[Igor Morr @igormorr]

https://t.co/YKQQ7aHBvb

[Igor Morr @igormorr]

https://t.co/11dVkIETTW

[Igor Morr @igormorr]

Panel: "Inteligencia Artificial y Salud: Dilemas éticos en la era digita... https://t.co/tfOu90I7QZ a través de @YouTube

[Igor Morr @igormorr]

Cardiologist Sues UPMC; BP Control in a Rut; GLP-1 Drugs During Pregnancy https://t.co/TOmXujsjsM

[American College of Cardiology @ACCinTouch]

A 🆕 ACC Scientific Statement outlines the rapidly evolving landscape of gene-editing therapies & their growing relevance to #CVD, offering clinicians an overview of both the promise and the challenges of this transformative technology.

Read more: https://t.co/wHPzZ7B3Od #JACC

[Heart_BMJ @Heart_BMJ]

Burden of chronic kidney disease and outcomes following hospitalisation for heart failure

https://t.co/Ej6D3vr2a5

[AbdAllah Othman @CardioBeat_]

https://t.co/KdVVg4FMAc
📈 ECG Cheat Sheet 🎯
Drop a ❤️ if you find this helpful! Feel free to share!
#ECG #EKG #Cardiology #MedStudent #NursingSchool

[Mo Imam @MoAImam]

Clotting

[Dr.Marlon Villanueva™ 🩺 𝕏 @MarlonVFZR]

🫀 𝗖𝗹𝗼𝗽𝗶𝗱𝗼𝗴𝗿𝗲𝗹 𝘃𝘀 𝗔𝘀𝗽𝗶𝗿𝗶𝗻𝗮 𝗽𝗼𝘀𝘁-𝗣𝗖𝗜: 𝗲𝘃𝗶𝗱𝗲𝗻𝗰𝗶𝗮 𝗮 𝟭𝟬 𝗮𝗻̃𝗼𝘀 (𝗛𝗢𝗦𝗧-𝗘𝗫𝗔𝗠)
⬇️⬇️⬇️⬇️

🧠 𝘿𝙞𝙨𝙚𝙣̃𝙤 𝙙𝙚𝙡 𝙚𝙨𝙩𝙪𝙙𝙞𝙤
👥 𝙋𝙤𝙗𝙡𝙖𝙘𝙞𝙤́𝙣: Pacientes estables tras 6–18 meses de DAPT luego de angioplastia (PCI)
💊 𝙄𝙣𝙩𝙚𝙧𝙫𝙚𝙣𝙘𝙞𝙤́𝙣: Clopidogrel 75 mg/día
⚖️ 𝘾𝙤𝙢𝙥𝙖𝙧𝙖𝙙𝙤𝙧: Aspirina 100 mg/día
🎯 𝙊𝙪𝙩𝙘𝙤𝙢𝙚 𝙥𝙧𝙞𝙢𝙖𝙧𝙞𝙤:
•Muerte CV
•IAM no fatal
•ACV
•Rehospitalización por SCA
•Sangrado mayor

📊 𝙍𝙚𝙨𝙪𝙡𝙩𝙖𝙙𝙤𝙨 𝙥𝙧𝙞𝙣𝙘𝙞𝙥𝙖𝙡𝙚𝙨 (𝙨𝙚𝙜𝙪𝙞𝙢𝙞𝙚𝙣𝙩𝙤 10 𝙖𝙣̃𝙤𝙨)

🔥 𝙀𝙣𝙙𝙥𝙤𝙞𝙣𝙩 𝙘𝙤𝙢𝙥𝙪𝙚𝙨𝙩𝙤
•Clopidogrel: 𝟮𝟱.𝟰%
•Aspirina: 𝟮𝟴.𝟱%
➡️ 𝙍𝙚𝙙𝙪𝙘𝙘𝙞𝙤́𝙣 𝙖𝙗𝙨𝙤𝙡𝙪𝙩𝙖 ~𝟯.𝟭%

🧠 𝙀𝙫𝙚𝙣𝙩𝙤𝙨 𝙞𝙣𝙙𝙞𝙫𝙞𝙙𝙪𝙖𝙡𝙚𝙨

𝙀𝙫𝙚𝙣𝙩𝙤 𝘾𝙡𝙤𝙥𝙞𝙙𝙤𝙜𝙧𝙚𝙡 𝘼𝙨𝙥𝙞𝙧𝙞𝙣𝙖
🧠 ACV 4.6% 6.4%
🩸 Sangrado mayor 5.6% 7.7%
🫀 Reingreso por SCA 8.7% 11%

👉 Beneficio consistente en:
•𝙀𝙫𝙚𝙣𝙩𝙤𝙨 𝙞𝙨𝙦𝙪𝙚́𝙢𝙞𝙘𝙤𝙨
•𝙎𝙖𝙣𝙜𝙧𝙖𝙙𝙤 (𝙙𝙖𝙩𝙤 𝙘𝙡𝙖𝙫𝙚)

⚖️ 𝙄𝙣𝙩𝙚𝙧𝙥𝙧𝙚𝙩𝙖𝙘𝙞𝙤́𝙣 𝙛𝙞𝙨𝙞𝙤𝙥𝙖𝙩𝙤𝙡𝙤́𝙜𝙞𝙘𝙖

🔬 𝘾𝙡𝙤𝙥𝙞𝙙𝙤𝙜𝙧𝙚𝙡 𝙫𝙨 𝙖𝙨𝙥𝙞𝙧𝙞𝙣𝙖:
🧬 𝘾𝙡𝙤𝙥𝙞𝙙𝙤𝙜𝙧𝙚𝙡 (𝙋𝟮𝙔𝟭𝟮)
•Inhibición más específica de activación plaquetaria
•Menor daño mucoso GI
•Menor inflamación vascular
🧪 𝘼𝙨𝙥𝙞𝙧𝙞𝙣𝙖
•Inhibición COX-1
•Mayor riesgo de sangrado GI
•Efecto menos selectivo

🚨 𝙃𝙖𝙡𝙡𝙖𝙯𝙜𝙤 𝙘𝙡𝙞́𝙣𝙞𝙘𝙤 𝙙𝙞𝙨𝙧𝙪𝙥𝙩𝙞𝙫𝙤

👉 Tradicionalmente:
➡️ Aspirina = estándar de monoterapia post-DAPT

👉 Este estudio demuestra:
➡️ 𝘾𝙡𝙤𝙥𝙞𝙙𝙤𝙜𝙧𝙚𝙡 𝙚𝙨 𝙨𝙪𝙥𝙚𝙧𝙞𝙤𝙧 𝙖 𝙡𝙖𝙧𝙜𝙤 𝙥𝙡𝙖𝙯𝙤 (𝟭𝟬 𝙖𝙣̃𝙤𝙨)

📉 𝙈𝙖𝙜𝙣𝙞𝙩𝙪𝙙 𝙙𝙚𝙡 𝙗𝙚𝙣𝙚𝙛𝙞𝙘𝙞𝙤
🔻 Reducción absoluta modesta pero clínicamente relevante
📈 Beneficio sostenido en el tiempo
⚠️ Mejor perfil 𝙞𝙨𝙦𝙪𝙚́𝙢𝙞𝙘𝙤 + 𝙝𝙚𝙢𝙤𝙧𝙧𝙖́𝙜𝙞𝙘𝙤 𝙨𝙞𝙢𝙪𝙡𝙩𝙖́𝙣𝙚𝙖𝙢𝙚𝙣𝙩𝙚

🧠 𝘼𝙥𝙡𝙞𝙘𝙖𝙘𝙞𝙤́𝙣 𝙥𝙧𝙖́𝙘𝙩𝙞𝙘𝙖

📌 𝘾𝙤𝙣𝙨𝙞𝙙𝙚𝙧𝙖𝙧 𝙘𝙡𝙤𝙥𝙞𝙙𝙤𝙜𝙧𝙚𝙡 𝙘𝙤𝙢𝙤 𝙥𝙧𝙞𝙢𝙚𝙧𝙖 𝙤𝙥𝙘𝙞𝙤́𝙣 𝙚𝙣:
•Post-PCI estable tras DAPT
•Alto riesgo de sangrado GI
•Historia de eventos isquémicos recurrentes
•Intolerancia a aspirina

⚠️ 𝙇𝙞𝙢𝙞𝙩𝙖𝙘𝙞𝙤𝙣𝙚𝙨 𝙧𝙚𝙡𝙚𝙫𝙖𝙣𝙩𝙚𝙨
🌏 Mayoría población asiática → posible variabilidad farmacogenómica (CYP2C19)
🧬 Metabolismo de clopidogrel dependiente de activación hepática
❗ No aplica automáticamente a todos los fenotipos globales

‼️Si te sirve: ❤️ Me gusta | 🔁 Repost | ➕ Follow para más #MedED en #ClubCrit 😄🧠🫶

👇🏼👇🏼👇🏼👇🏼
📚📖#ClubCrit

#AAS #ASA #Clopidogrel #Aspirina #CardioX #CritCare #UCI #ICU #CriticalCare #Diagnóstico #icu #intensivecare #diagnosis #management #POCUS #VExUS #MedicinaBasadaEnEvidencia #Terapia #MedEd #Medicina #FOAMed #FOAMcc #CuidadoCrítico #MedX #EducaciónMédica #MedIntensiva #MedXCommunity #MedicinaCrítica #MedED #CritCare #ICUManagement #MustRead #LecturaRecomendada

[Medscape @Medscape]

Among working-age adults in the US, COVID was associated with higher risks for acute kidney injury (AKI), chronic kidney disease (CKD), or end-stage renal disease (ESRD) than influenza. The risk for AKI was greatest soon after infection, whereas the elevated risk for CKD persisted over a longer follow-up period. https://t.co/pMmyK49S6Y

[JACC Journals @JACCJournals]

This post hoc analysis of ISCHEMIA with 4-year outcome demonstrated that ischemia severity by #CMR had a stronger association with all ISCHEMIA trial endpoints compared with SPECT/echo. https://t.co/qXmoeLJ9iH #JACCIMG

[Igor Morr @igormorr]

Join me at New Horizons in Cardiomyopathy 2026! Find out more at https://t.co/alTMFYkMtO #NHCCongress2026

[Igor Morr @igormorr]

Sex-specific differences in cardiovascular risk factors and implications for cardiovascular disease prevention in women - Atherosclerosis https://t.co/J5fhREULiL @SIAC_cardio @mencardio @FUNDAPROCECA @igormorr #Dr.Igormorr

[Igor Morr @igormorr]

Aterosclerosis silenciosa: por qué llegar tarde ya no es una opción https://t.co/KBRlgtFh04 #igormorr @igormorr #Hablando de salud @hablandodesalud @fundaproceca @SVCardio @SIAC_cardio @mezayo

[Igor Morr @igormorr]

"Estudio piloto sobre el efecto del ejercicio en la excreción urinaria de albumina en pacientes hipertensos, diabéticos y diabéticos con hipertensión arterial" — Read it on @ResearchGate: https://t.co/59dQrX6ESE

[Igor Morr @igormorr]

El argumento para una reducción temprana del colesterol LDL: apoyando el envejecimiento vascular saludable de por vida - American College of Cardiology https://t.co/4Z6s7i3ygg @mencardio @SIAC_cardio @CardiologiaSVC @FUNDAPROCECA