John

Science

[tern @1goodtern]

It's now a very widely established scientific fact that covid infections are not all cleared within weeks of infection.

It's not clear what proportion of people undergo persistent infection, but it's not a trivial number, or a rare occurrence.

[Zdenek Vrozina @ZdenekVrozina]

Interferon works against SARS2. In these experiments it knocks infection down by 80 to 96%.
But it doesn’t cut evenly. What it leaves standing is the spread that runs by a route it can’t reach.
A new NIAID paper shows what that did to spike evolution🧵

[tern @1goodtern]

When you look at this, remember that Covid infections can cross the blood brain barrier, as well as cause brain inflammation, as well as cause damage to neurons, as well as trigger auto-immune disorders in the brain, all of which can make anxiety and depression more likely.

[Manuel Ruiz @manruipa]

🔴⚠️‼️Have you heard a flood of news stories about Epstein-Barr virus and multiple sclerosis over the last few days?

Pay attention, because many headlines are telling the story incorrectly. Or, at the very least, they are telling you only part of it.

The news is not simply that “the mononucleosis virus activates certain lymphocytes.”

Nor have we only just discovered that Epstein-Barr virus is associated with multiple sclerosis. This had been suspected for decades and became extraordinarily well supported in 2022.

The real news is that we are beginning to understand how a virus that remains inside our B cells for life could keep the immune circuit that eventually attacks the nervous system switched on.

And that completely changes the therapeutic question:

Why do we continue limiting ourselves to suppressing the immune system without also trying to control the virus that is probably fueling the process?
(1/14)🧵👇🏻

[SARS‑CoV‑2 (COVID-19) @COVID19_disease]

🚨 BREAKTHROUGH: World’s First Vaccine Targeting the Entire SARS Coronavirus Family Begins Human Testing

Imagine a vaccine that doesn’t just fight COVID but every SARS-related virus, including ones still hiding in bats, waiting to jump.

That’s GBP511. And it just started human trials in Australia.🧵

[tern @1goodtern]

Like I said:
Our society has thrown away the process of risk management of Covid and processes of risk management for other diseases and hazards will inevitably follow.

[Zdenek Vrozina @ZdenekVrozina]

Where does spike sit? Tissue reservoirs - gut, lymph nodes, meninges. The review proposes mast cells soak it up and store it, and the meninges are full of them.
Proposed, not directly shown. But there’s precedent - mast cells are a documented reservoir for HIV.

[Marlo Van Marck @MarloVanMarck]

STOP GETTING INFECTED WITH THAT DAMN VIRUS

I promise you- “Neurodegeneration” is not a term you want to hear out of your doctor’s mouth when he is giving you the bad news about your new disease symptoms.

[Corruptario @corruptario]

COVID infection can accelerate cancer and activate dormant cancer cells. 🤫

[tern @1goodtern]

🚨OH MY WORD. I WARNED FOUR YEARS AGO THAT REPEAT COVID INFECTIONS IN KIDS MIGHT LEAD TO EXACTLY THIS CONDITION.

[Zdenek Vrozina @ZdenekVrozina]

An Italian group took stomach lining biopsies from people with Long COVID and counted the nerve fibers in them. Under endoscopy the mucosa looked normal. Under a fluorescence microscope, roughly half the fibers were gone.🧵

[Zdenek Vrozina @ZdenekVrozina]

The study in Clinical Ophthalmology - LISTEN, 595 people with long COVID.
57% report new ocular symptoms - blurred vision, dry eyes, floaters or flashes. The headline isn’t really about the eyes🧵

[Jon Douglas @atranscendedman]

Maybe the bigger @bryan_johnson story is that medicine keeps asking blood to tell stories only tissue can tell.

[SARS‑CoV‑2 (COVID-19) @COVID19_disease]

🚨 BREAKTHROUGH: Scientists from McMaster University have developed AeroVax a breathable vaccine mist that delivers immunity directly to the lungs in just 2 minutes.🧵

[Zdenek Vrozina @ZdenekVrozina]

A German study followed 74 children and teens with severe long COVID for up to 3 years after infection, measuring their immune systems repeatedly. The finding worth unpacking - that immune picture kept shifting over time. It wasn't frozen in place.🧵

[CoronaHeadsUp @CoronaHeadsUp]

Possibly 1 in 4 children may develop Long COVID, even after vaccination

[Harry Spoelstra @HarrySpoelstra]

Folic Acid and Endothelial Dysfunction in COVID-19

🚨LongC0VID still has zero proven treatments. 🧵

➡️A new Argentinian review shows folic acid could protect blood vessels from the endothelial damage driving both severe cases and persistent symptoms, by lowering homocysteine, boosting nitric oxide, and countering the gut disruption COVID causes,

Sceptical? Same here!

➡️But when we literally have nothing else that works, dismissing a cheap, safe vitamin without proper trials is no longer cautious, it may even be negligent,

And, if there’s no added value, it certainly won’t harm you to try!

➡️Some interesting points from this review:
1. Endothelial dysfunction drives severe acute COVID-19 (inflammation, thrombosis, organ damage, ICU needs) and longC0VID/PASC symptoms,

2. Homocysteine metabolism is frequently dysregulated in COVID-19 inflammation. Elevated levels correlate with higher clotting risk, severe pneumonia, ICU admission, and mortality. Severe patients often show low folate and high homocysteine,

3. Folic acid (vitamin B9) lowers homocysteine, reduces oxidative stress, supports nitric oxide production (improving vasodilation and reducing inflammation/clotting), and may exert direct antiviral effects by interfering with SARSCoV2 entry/replication proteins,

4. SARSCoV2 disrupts the gut microbiome, reducing natural folate production by beneficial bacteria and worsening deficiencies/inflammation,

5. Evidence cited includes biomarker studies, computational/lab data on mechanisms, genetic susceptibility links, and some clinical observations where nutritional support including folic acid was associated with reduced mortality and mechanical ventilation needs,

6. Supplementation is discussed as a low-cost complementary strategy for acute phase and longC0VID (with vitamin B12 also noted for LC/PASC👇),

7. It is not presented as a cure or standalone treatment,

8. The review does call for larger, well-designed clinical trials to confirm indication, optimal dosing, efficacy, and patient subgroups.

‼️So, Folic acid shows credible mechanistic promise as an affordable vascular shield against COVID-19’s endothelial assault, yet we still have zero proven treatments for LongC0VID. Without urgent, large-scale trials, millions will keep suffering preventable clotting, organ damage, and chronic symptoms while a simple, cheap B-vitamin may sit underutilized. The paper’s evidence is suggestive and certainly not definitive. Treating this as “just another supplement” or dismissing it outright risks turning a potential low-cost adjunct into yet another missed opportunity in a disease that continues attacking blood vessels long after the virus is gone.
The evidence is preliminary. The need to test it seriously is not, anything that may help needs our attention! Meanwhile:
#AvoidSars2 #AvoidReinfections 1/2
https://t.co/NOTdKDM743

[Trish Catwin @trishorwen]

Well done everyone — we’re killing our children.

[Amante @DeVerdadera1]

More than six years after #COVID started, not one person can present scientific evidence proving that the current #SARSCoV2 variants are less likely to cause post-acute multi-organ damage and disabilities (#LongCOVID) in SARS-CoV-2-naive people in 2026 than they were in 2020. 🦠

[Laura Miers @LauraMiers]

“This is not a respiratory virus. This virus is like a cancer. This virus gets into every part of your body.”

This isn’t hyperbole. SARS-CoV-2 persists in nearly every organ & organ system. Indefinitely. Most people are not clearing this virus. The public is entirely unaware.