INCEPT

INCEPT: The Intensive Care Platform Trial research programme. Profile no longer active, updates on website:

[INCEPT @INCEPTdk]

The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients. Follow this account and https://t.co/6BLGMKepcB for updates!

[Maj-Brit N Kjær @Majkja]

@AndersPerner @INCEPTdk @oxenboellcollet We are so thrilled to receive this award on behalf of all the research panels involved. For the curious reader our core outcome set is now available as a preprint: https://t.co/Tt3N7AXB2z

[Anders Granholm @andersgranholm]

adaptr #rstats package for simulating complex adaptive trials with adaptive stopping, arm dropping, and randomisation updated to v.1.40 - link and details below. @INCEPTdk

[ATS Blue Journal @ATSBlueEditor]

A step into the future of clinical trials, shaped by the critical care community.

@PRACPLATFORM
@REMAP6 @EdinUni_TRAITS @INCEPTdk @panther_trial @remap_cap @AndersPerner @msh_manu @ecgoligher @efan75 @dfmcauley @srinmurthy99

🔗 https://t.co/Rl1KLB9OjQ

[Michael Harhay @Michael_Harhay]

'The Rise of Adaptive Platform Trials in Critical Care'

New @ATSBlueEditor led by @ecgoligher @efan75 @PRACPLATFORM w/* @REMAP6 @EdinUni_TRAITS @INCEPTdk @panther_trial @AndersPerner @msh_manu
@srinmurthy99 @dfmcauley @SarinaKS

🔓: https://t.co/Rxt5KsEykk

*tagged my best

[Michael Harhay @Michael_Harhay]

Interested in conditional average treatment effects (ie, CATE) to assess HTE in a Bayesian causal framework?

Chk out (esp our supp & git page): https://t.co/Se8YUwmmAd

Co-led by @BryanBlette & @andersgranholm, w/ @msh_manu @AndersPerner @FanLi90 & some of the @INCEPTdk team.

[Anders Granholm @andersgranholm]

New version of our 'adaptr' R package on CRAN including important new functionality (trial calibration) and other improvements - see https://t.co/nELvbfYfek and thread below if you're interested in simulation of complex adaptive trial designs. 1/..

[Anders Granholm @andersgranholm]

Are days alive without life support/out of hospital (DAWOLS/DAOOH) associated with longer-term health-related quality of life (HRQoL)?
We aimed to find out - new article online (OA), https://t.co/glzEqSWqST, conducted as part of the @INCEPTdk programme.
1/..

[Anders Granholm @andersgranholm]

Version 1.2.0 of the 'adaptr' R package for simulating adaptive clinical trials with adaptive stopping, arm dropping and randomisation on CRAN; details at: https://t.co/nELvbfYfek w/ @benskov @LangeTheis Aksel KG Jensen @INCEPTdk 1/..

[Anders Granholm @andersgranholm]

Now online in @JClinEpi (OA): https://t.co/Ton5G8x2sH
In this manuscript we provide an overview of the key methodological considerations for (multi-arm, multi-stage) clinical trials using adaptive stopping, arm dropping, and randomisation with a worked example. Details below 1/

[Benjamin Skov Kaas-Hansen @epibendk]

#causalinference from #ICU #secondarydata could inform and guide critical care #RCTs. But is it used? We're setting out to find out: https://t.co/yb5gu3ZXWY @INCEPTdk

[Anders Granholm @andersgranholm]

New paper in @CritCareMed: to inform selection and handling of patient-important outcomes other than mortality in @INCEPTdk, we conducted a scoping review summarising selection, definition, and handling of these outcomes in contemporary ICU trials (1/..) https://t.co/neh9MmFVx8

[Anders Granholm @andersgranholm]

Minor update to the 'adaptr' R package for adaptive trial simulation now available on CRAN (https://t.co/39LnNMtcKh). Details on the package available below and on https://t.co/nELvbfYfek. @INCEPTdk @benskov @LangeTheis

[INCEPT @INCEPTdk]

This week, the INCEPT programme received the ‘Innovation of the year’-award in the first Danish awards ceremony for clinical trials. We are proud and highly motivated to continue our work on establishing the INCEPT platform trial! Coverage (in Danish): https://t.co/4d7cSRMQ9o

[Anders Granholm @andersgranholm]

We have a paper on our 'adaptr' R-package for adaptive trial simulation and comparison (developed as part of the @INCEPTdk project) published in @JOSS_TheOJ https://t.co/hZSQEgB3JU.
The package is documented on a stand-alone website at https://t.co/nELvbfYfek. (1/6)

[JOSS @JOSS_TheOJ]

Just published in JOSS: '`adaptr`: an R package for simulating and comparing adaptive clinical trials' https://t.co/bDQTf3Om5O

[Anders Granholm @andersgranholm]

Now also available on CRAN: https://t.co/39LnNMtcKh

[Anders Granholm @andersgranholm]

adaptr: Adaptive Trial Simulator - new #rstats package for simulating adaptive trials:
https://t.co/nELvbfYfek
Simulates/compares trial designs using adaptive stopping, arm dropping and randomisation. Developed as part of the @INCEPTdk project. Details below: (1/6)

[DASAIM @DASAIMdk]

Development of a core outcome set for general intensive care unit patients—A protocol #StrongWork
https://t.co/DnduyvQ3Tf