IntAct at EBI

The Molecular Interactions Database at the EMBL-EBI. Open Source Framework for Molecular Interactions. Also follow➡️@complexportal.

[IntAct at EBI @intact_project]

Registration is free but essential: https://t.co/mIcb2JJio4 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

[IntAct at EBI @intact_project]

✨ New in IntAct✨

We’ve integrated the GPCR–RAMP interactome from Sakmar lab’s study 🧬🔬

🔗 [https://t.co/AtNwSHJH91]

🔹 215 GPCRs tested
🔹 122 show strong RAMP interactions
🔹 23 endogenous GPCR–RAMP complexes identified

#GPCR #Interactome

[IntAct at EBI @intact_project]

Freely accessible via IntAct: https://t.co/e4K7DwwD7u

👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social
and the team for their collaboration in bringing this integration to IntAct!

#IntActEBI #PPI #NetworkBiology

[IntAct at EBI @intact_project]

🔬✨New in 𝐈𝐧𝐭𝐀𝐜𝐭!

Quantitative fragmentomics data (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

[IntAct at EBI @intact_project]

📌 Each interaction includes 𝐛𝐢𝐧𝐝𝐢𝐧𝐠 𝐚𝐟𝐟𝐢𝐧𝐢𝐭𝐲(𝐊𝐝), so you can see not just if proteins interact, but how strongly.

🚀 Enabling better network biology, pathway modeling, variant interpretation & drug discovery.

[IntAct at EBI @intact_project]

IntAct release 252 is out! 1,787,152 binary interactions from 23,889 manually curated publications https://t.co/79WofBWvti (in sync with UniProt release 2025_04)

[IntAct at EBI @intact_project]

👏 Huge thanks to UniProt for integrating the isoform information! 🤝 This was a joint curation effort by IntAct & UniProt - a great example of collaborative science! Here’s to an exciting year ahead! 🚀🧬 https://t.co/qydcRo7fBO
#EMBLEBI #IntActEBI #UniProt #Proteoforms

[IntAct at EBI @intact_project]

📷
IntAct
@intact-ebi.bsky.social
🎉✨ Happy 2026! ✨🎉 We’re excited to kick off the year by sharing the integration of the work “N-terminal proteoforms may engage in different protein complexes” from the Kris Gevaert lab (VIB, Ghent, Belgium) 🎓🔬

[IntAct at EBI @intact_project]

Study beautifully demonstrates how N-terminal proteoforms can reshape protein interactomes - gaining new interactions and/or losing others compared to their canonical counterparts - highlighting the power of proteoform diversity in cellular networks.

[IntAct at EBI @intact_project]

Registration is free but essential: https://t.co/mIcb2JJio4 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

[EMBL-EBI @emblebi]

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:

“AI is showing how vital data curation really is.”

https://t.co/x5TLvFmYn8

#biocuration #FAIRdata

[EMBL-EBI @emblebi]

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work for important open data resources including:

@uniprot
@complexportal
@intact_project
@news4go
@InterProDB

[IntAct at EBI @intact_project]

Registration is free but essential: https://t.co/mIcb2JJio4 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

[IntAct at EBI @intact_project]

Would you like to learn more about molecular interactions & to explore them across organisms? Join us next week for an introductory webinar where we walk through the IntAct's approach to molecular network modelling & show how this is implemented within the IntAct Cytoscape app.

[IntAct at EBI @intact_project]

🧫 Explore the curated dataset in IntAct ➡️ https://t.co/aPCDfX7IlK

🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)

[IntAct at EBI @intact_project]

✨🧬New on IntAct! ✨

Interaction data from the study
📖“Global fungal��host interactome mapping identifies host targets of candidalysin” - from Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉

[IntAct at EBI @intact_project]

Maps the interactome of all eight Candida albicans ECE1 propeptides and their specific human protein targets, revealing both unique and shared host interactions that provide new insights into fungal–host communication.

[IntAct at EBI @intact_project]

📥 Submit your data here:
🔹 IntAct: https://t.co/A7dsJpVoNO
Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable.

#Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBLEBI #IntActEBI #OpenScience #UniProt #DataMatters

[IntAct at EBI @intact_project]

Want your PPI or structural data to make an impact?
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct: https://t.co/uHhIYN9SZI

[IntAct at EBI @intact_project]

Don’t just publish - be found! 🔍 I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.

[UniProt @uniprot]

There’s still time to register for our webinar on the upcoming changes to the UniProt Proteomes database.
Learn how Proteomes and UniProtKB will change and how this might affect you. Thursday 23rd October 15.00 (BST)
Registration is free but essential; https://t.co/eMb7BTOZ0N