Just published: "Sex [brain] differences in task-activation are widespread... and reproducible, largely task-specific, of small to moderate effect size, and unaligned with brain volume differences."
https://t.co/92VFQ4fYhQ
New research finds that very high intelligence is associated with the cumulative effect of hundreds of genetic variants of small individual effect, while very low intelligence is associated with a small number of rare variants of large individual effect.
https://t.co/fPJR0adinv
"The most highly predictive polygenic scores in the behavioural sciences are for cognitive traits... Polygenic g score showed minimal prediction in toddlerhood, modest prediction in childhood, and substantial prediction by early adulthood."
https://t.co/yi2k3lR1H8
@ShimonKokhba@sputnikswe@grok@magattew "When a black kid gets 85 on IQ test today that would be like 105 today generations ago What persists is the disparity between blacks and white IQ which is attributed to the things mentioned before,"
This is directionally correct. Please look up Flynn Effect.
New from David's Reich's lab: "In the past ten millennia [in Europe], we find that many hundreds of alleles have been affected by strong directional selection," including those influencing human intelligence.
https://t.co/GRv4rBOnF4
The "[in Europe]" above refers to West Eurasia, which includes areas now included in Europe and West Asia (from which most of the migration to Europe occurred).
"We also document one-standard-deviation changes on the scale of modern variation in combinations of alleles that today predict complex traits. This includes decreases in predicted body fat and schizophrenia, and increases in measures of cognitive performance."
"Within families, higher PGS predicts greater educational attainment [and] occupational status... with no evidence for gene-environment interactions... These findings... reflect properties of cognitive genetic architecture rather than idiosyncrasies of a particular score."
"Relying on a newly constructed PGS using within-family designs... we demonstrate that direct genetic effects account for the large majority of PGS prediction... the within-family association with latent general ability is approximately 0.45."
https://t.co/z3Ji6Qkru2
"Combining text, genetic markers, and teacher assessments into an ensemble model, we can predict cognitive ability at close to test-retest reliability of gold-standard tests."
"[Using LLM] trained on short aspirational essays written at age 11, we accurately predict [cognitive test scores]... to a similar degree as teacher assessments, and better than genomic data."
https://t.co/NOHf2rEEuW
"The connectedness of frontal and parietal regions was associated with individual test performance. Further... higher test scores were linked to more complex long-range processes and, at a trend level, to less complex short-range processes."
Brain scans of people taking intelligence tests showed that high scores were linked to highly flexible, diverse neural networks.
https://t.co/Aqq6Stl6hW
"Our PGS predicts higher educational attainment, occupational status, and family income within families, and retains good performance in non-European ancestry samples."
"We present a polygenic score (PGS) for general cognitive ability (GCA) that demonstrates a substantial increase in predictive accuracy... the inverse-variance-weighted within-family association of the PGS with [latent GCA] is estimated at 0.448."
https://t.co/2oaimxJpSp