Very excited to hear that our #MenB#vaccine awareness paper is ‘basically acceptable for publication’! @BastaLab PI @IDEpiPhD shared the results of this study @ipnc2018 and got lots of great feedback. Paper will be out soon!
Time to fly back with lots of good memories from @ipnc2018 with sincere thanks to the organizers @BeerninkPeter for the wonderful management and to everyone who has contributed with their oral/poster presentations.
Yonatan Grad on evolution & spread of antibiotic-resistant N. gonorrhoea. Some lineages acquire and maintain resistance much more efficiently than others.... #IPNC2018
Ellen Aho and Maggie So talk about inhibitory/antimicrobial effects of commensal oral Neisseria on other N’l species. For me: yet ANOTHER reason for not restricting mening-protein antigen vaccine carriage studies to looking for effects on carriage of invasive Nm strains #IPNC2018
Michael Jennings N. gonorrhoea pili bind to I-domain of cd11b/cd18 aka CR3 on cervical cells. Drugs including carbamazepine & MeDOPA block this interaction. Potential novel approach to treatment. I wonder whether people taking these drugs for CNS diseases are protected #IPNC2018
Attending #neisseria conference #ipnc2018 in Asilomar. 63 talks from North America, Europe & Australia chosen from ~320 participants. No talks by #LMICs participants. Where on the globe is the highest burden of #meningitis & #STI one might wonder.
Y Tekletsion suggests increased NP bacterial density ass'd with lower bacterial gene expression. Overall low expression of fhbp in carriage @adamhfinn#IPNC2018
Neil McAlasdair found substantially more recombination from N. gono into N. meningitidis than vice versa - interesting implications for evolution and management? #IPNC2018
#ipnc2018 @OdileHarrison showing the power of cgMLST in analysing gonococcal populations & diversity. cgMLST scheme available at https://t.co/TB8QUIfg8l
Ladhani on UK programme to prevent MenW (cjACWY in teens) Overall annual number of cases went down this year for first time since 2009. Suggests programme now working across the population by indirect effects. Bexsero may also be impacting on cases in young children #IPNC2018
MM Mustapha describes microevolution of Nm during carriage and transmission. Some genes change fast even if same strain same person at a different time. Such changes also seen in isolated from contacts - so don’t prevent transmission #IPNC2018