Ivan Mladenovic

Husband, Dad, Connector of Dots+People, Investor. Building new things post-exit. Loves travel, bball, & wine. Hates laziness.

[Ivan Mladenovic @ivanmladenovic]

Growth mindset is my love language.

[Ivan Mladenovic @ivanmladenovic]

@mcuban @DrDiGiorgio And teachers.

[Ivan Mladenovic @ivanmladenovic]

While I don’t love the Knicks, and I’m annoyed they’re roasting the Spurs, I’m still so so so happy we’re watching this instead of SGA and the Floppettes. #nbafinals

[Wise @trikcode]

Before AI, I had 5 unfinished projects.
After AI, I have 128 unfinished projects.

[Ivan Mladenovic @ivanmladenovic]

@hthieblot Ebaumsworld

[Ivan Mladenovic @ivanmladenovic]

Where’s the best place in #Miami to watch sports + awesome food?

[Ivan Mladenovic @ivanmladenovic]

@davidrgoldberg Buccan in Gables
400 Vinyl
Cho Funky

[Ivan Mladenovic @ivanmladenovic]

This is WILD. Gene editing just produced a serious clinical result.

Verve Therapeutics (now part of Eli Lilly $LLY) released Phase 1b data on VERVE-102, a one-time IV infusion that uses base editing to permanently switch off the PCSK9 gene in the liver.

The result: up to 62% reduction in LDL cholesterol from a single dose, sustained out to 18 months so far. 35 patients. No serious adverse events.

Today, high cholesterol is managed with a daily statin for life. If this holds up in Phase 2 and 3, the model becomes: one infusion, done.

The GLP-1 comparison gets thrown around. Worth remembering Ozempic was already approved for diabetes when Phase 2 obesity data dropped. VERVE-102 has 35 patients across six dose cohorts. Different risk picture.

Chronic disease management is slowly being replaced by one-shot biological edits. Heart disease still kills more people than anything else. If this works, it's a category change.

Phase 2 starts by year end.

[Afshine Emrani MD FACC @afshineemrani]

1/5
I'm a cardiologist. I have spent twenty years watching cholesterol destroy arteries, trigger heart attacks, and kill people I care about.
Today, Eli Lilly presented data that may begin to end that era.
VERVE-102. A single infusion. One dose. It uses base editing to permanently turn off the PCSK9 gene in your liver.
Presented today at the European Atherosclerosis Society Congress:
88% reduction in PCSK9.
62% reduction in LDL cholesterol.
Sustained up to 18 months.
No treatment-related serious adverse events.
One infusion. Not daily pills you forget to take. Not monthly injections. One dose — and your cholesterol may stay low for the rest of your life.

[Ivan Mladenovic @ivanmladenovic]

@giyu_codes This is next level; TY.

[Ivan Mladenovic @ivanmladenovic]

@_jamico Let’s fix it. I’m deep in the Grove, with real estate and hospitality. It’s an incredible place. What’s it missing to become the hub?

[Ivan Mladenovic @ivanmladenovic]

A crowning parenting achievement is when you go to your first, real kindergarten parent/teacher conference and she says “no notes.”

[Ivan Mladenovic @ivanmladenovic]

Tesla FSD Mad Max mode is the perfect aggressive, polite driver. Except for potholes. It sucks for that.

[Ivan Mladenovic @ivanmladenovic]

Being nice to people is an underrated superpower.

[Dave Morin 🦞 @davemorin]

The revolution will not be tokenized.

[Ivan Mladenovic @ivanmladenovic]

There’s little I want more in this world than a cyber cab and a Home robot.

[Ivan Mladenovic @ivanmladenovic]

Using a handheld milk frother to spin your protien drinks, vitamins, and powders is life changing. It's like #FSD for shakes. #lifehacks

[Ivan Mladenovic @ivanmladenovic]

FSD has completely ruined driving for me. I will never touch a steering wheel again. The only exception: 100+ mph in a supercar.

[Ivan Mladenovic @ivanmladenovic]

@giyu_codes No, the focus of modern IT companies is exclusively recurring revenue. There is an NRR component with one time projects, but the more recurring revenue, the more enterprise value.

[Ivan Mladenovic @ivanmladenovic]

Please sweet jesus let this be true.

[Elon Musk @elonmusk]

New Roadster unveil hopefully next month.

It will be a banger next-level.

[Ivan Mladenovic @ivanmladenovic]

I don’t understand a universe anymore where my car does not drive me.