Retired psychologist, LL coach (16 yrs). Married for 45 yrs to PJ, father to 3 good men. Granddad to Nelli. NovaScotia? Collective consciousness advocate.
AIPAC spent $30 million trying to defeat Abdul El-Sayed in the primary. They lost.
Now, they plan to spend tens of millions more against him in the general election.
This is not democracy. This is oligarchy and a corrupt billionaire-funded campaign finance system.
Fight back.
TODAY'S TRUMPER MAGA PEDOPHILE IS MATTHEW PLATT. MATTHEW WARNED US THAT TRANS FOLKS WOULD MOLEST OUR CHILDREN [He was sentenced to 7 years in prison for molesting a child. Not Trans, just MAGA]
Keep your children away from MAGA
In my latest substack I discuss the Collins Media Industrial Complex, the increasing popularity of economic populism & building & rebuilding the grassroots movement from the ashes of the Platner campaign.
En Sudán, el genocidio prosigue ante el silencio de los medios de comunicación, las milicias terroristas de las RSF, respaldadas por Emiratos y el imperio occidental, mataron a esta madre delante de su hijo.
Si este video fuese de Ucrania o de cualquier pais europeo daría la vuelta al mundo, pero como es Sudán ni siquiera te informan sobre el genocidio en curso.
Recordar que esta guerra empezó después de que el gobierno de Sudán acordara una base naval de Rusia en el pais, además de por el saqueo masivo del oro que Emiratos lleva a cabo en el pais.
so apparently white americans in minneapolis are putting mexican flags on their cars so ice agents waste time pulling them over. they callit ice fishing.
@tylermilliken_ This guy could be our shortstop for the next 10 years.He's 20. They rushed Mayer, and look what happened. Let Arias stay in Double A the rest of the year.
I’m really struggling with the whole Mitch McConnell thing. Like is the Democratic Party so weak, not one will book a flight to walk into the hospital or hire a PI to determine he’s dead? Do we not have investigative journalists anymore? WTH is happening & why is no one checking?
$NWBO #DCVax
Right now, somewhere, a wave is crossing open ocean at five hundred miles an hour.
It is two feet tall.
A ship sails over it and the crew feels a swell nobody mentions at dinner. The energy is not in the height. It is in the length. That wave runs a hundred miles from crest to crest, reaches all the way down to the seabed, and carries that energy across six thousand miles of water without losing any of it, because in deep water there is nothing to spend it on.
You cannot see it. That is not a flaw in the wave. That is what a wave that size looks like before the floor comes up.
The wave never changes. The floor does.
In 2000 Ralph Steinman named the control point. Maturation. Not the antigen, not the dose, not the route. The state of the presenting cell at the moment it presents.
In 2001 Kalinski warned that the field's standard maturation recipe contained prostaglandin E2, and that PGE2 shuts off IL-12. The instruction itself.
The field adopted it anyway.
That is the deep water. Twenty-five years of energy accumulating flat, suppressed by a convention nobody went back and re-examined.
Four findings. Three institutions. Twenty years. Different cancers. The same variable in all of them.
Argos, kidney cancer. The phase 3 was stopped for futility, and IL-12 output was the biomarker still standing when it was over.
Liau 2005. T-cell infiltration tracked survival. TGF-β2 tracked it in reverse. She raised the army and named the thing that switched it off at the door.
Everson 2024. Poly-ICLC arm, median overall survival 52.5 months against 7.7 on placebo, log-rank p=0.017, and lower risk of death held on adjustment for grade, MGMT and recurrences.
DCVax-Direct phase 1. Forty patients who had failed everything, sorted by how much cytokine their own cells made. The curves separate. IL-12 p40, p=0.028.
Then the piece that closes it. From the Kalinski portfolio, published May 2025: block TGF-β signaling while the cell is maturing and the state locks in. What a dendritic cell becomes is decided during maturation and cannot be undone after. The vaccine reaches the tumor already deaf to the signal waiting there.
Liau named that suppressor in 2005, in the tumors of patients whose responses died at the door. Twenty years later the answer is a cell that cannot hear it.
Then the waiting. Over 900 days at the MHRA, on a file that got stronger while it sat.
Somebody had to understand this before it was safe to understand it.
Linda Powers has run this company for nearly two decades. Through the short campaigns, the funding droughts, the clinical hold, and a long stretch when the field had written dendritic cell vaccines off as a dead end.
She also understood what almost nobody does. In cell therapy the manufacturing is the product. If the state of the cell at the moment it presents is what decides, then everything is decided in the flask, in eight days, before a single patient is treated.
So she built the flask.
Flaskworks and the #EDEN system. Closed, automated, the same cell made the same way at scale.
And #AdventBioservices. She owned it, carried it through the years the company could not, then handed it to the shareholders for a fraction of what it was worth.
Read that again. The usual story runs the other way.
Then exclusive rights to Kalinski's portfolio, both of them, more than twenty years of the work that named the polarization.
Reading a paper is easy. Building the flask for eighteen years while the field tells you the idea is dead is not.
Now the part people miss.
Before it arrives, the water leaves.
The trough reaches shore first, so the sea pulls back. Not a tide. A withdrawal. Hundreds of yards of seabed lifted into daylight that has not touched it in a century, fish flapping on wet sand, boats sitting down on their keels, the whole bay simply gone.
It is beautiful, and people walk out into it. They always do.
Fifteen cents.
Nobody out there is walking on dry ground. They are standing on the front of the wave.
The wave gains nothing in the shallows. It has carried the same energy the whole way. The floor rises, five hundred miles an hour becomes thirty, and everything it has been holding since 1973 has nowhere left to go but up.
Paradigm shifts work the same way. Nothing new arrives. The evidence was already there, accumulated flat, for twenty-five years, held down by a status quo that never re-opened the question.
What changes is the floor.
Then it stands up.
#DCVaxForBraelyn
@andrewcaravello@BrnAgainHuman Thanks for this Doc. I just don't understand what is taking MHRA so long. Do we need more automated production? Or is the MHRA tainted by BP money? The safety profile for DC Vax is unmatched.