Jan Domanski

Forbes 30U30, ex-CTO @Labstep, ex @DEShawResearch, ex @amazon. Software and drug-discovery at @charmtherapeutx

[Jan Domanski @jandom_random]

@m_goes_distance please put ONE thing in the clinic, just one

[Jan Domanski @jandom_random]

@owl_posting Automated wetlab services AWS

[Jan Domanski @jandom_random]

or – can — you?

[Jan Domanski @jandom_random]

can't help yourself can you claude

[Anshul Kundaje @anshulkundaje]

Am I losing my mind.

What the text says should be happening is NOT happening in the figures? The exons are NOT having higher confidence scores than the introns.

If it can't distinguish exons from introns reliably, I shudder to think what is happening in regulatory DNA 😬😬😬

[Alex Recouso @recouso]

Americans as soon as they arrive to a coffee shop in Europe

[Jan Domanski @jandom_random]

@DdelAlamo Man it's back to the 90s where the docking code works on some targets (khm khm those that it was parametrized on) and not others!

[Jan Domanski @jandom_random]

@ChrisHayduk @karpathy This is jokes, very cool😹 Wanna come to Barcelona and present it at the @open_fold cofolding summit?

[Minji Lee @m1nj12]

We introduce ConforNets, a mechanism for conformational control in AlphaFold3 models

- SoTA at producing diverse conformations on every multistate benchmark (N=104)
- Novel capability: transfer state from one protein to another

Outperforms BioEmu, ConforMix and AFsample3

🧵1/8

[Jan Domanski @jandom_random]

@miangoar just makes it easier for the pre-print servers to take over :P

[Jan Domanski @jandom_random]

@typesfast European mind truly cannot comprehend this 😹

[AMD @AMD]

Biology is moving to inference at scale.

As sequence length and complexity grow, so do compute and memory demands.

That’s where OpenFold3 by @open_fold + AMD Instinct GPUs come in:
• Up to 45.5% faster inference (AMD MI355X vs. NVIDIA B200, seq length 5K)
• Up to 22.1% faster inference (AMD MI300X vs. NVIDIA H100, seq length 3K)
• Longer sequences (up to 6,000 tokens)
• Thousands of structures predicted per day

Take a closer look ↓
https://t.co/Uiv55UUqq2

[Jan Domanski @jandom_random]

@divy93t @open_fold

[Jan Domanski @jandom_random]

They’re gonna have to jump on a quick MS teams call to resolve

[unusual_whales @unusual_whales]

BREAKING: The Artemis II crew encountered Microsoft Outlook issues en route to the Moon and requested help from ground control, per TechRadar

[Jan Domanski @jandom_random]

Even God needs 3 subagents

[Jan Domanski @jandom_random]

@oweissb @owl_posting Hahah

[Jan Domanski @jandom_random]

@owl_posting It’s a just a pretty mimetic industry: ozempic is a great example, and everyone trying to jump on that bandwagon now.

[Reuters @Reuters]

A Cuban mechanic, Juan Carlos Pino, modified his 1980 Polski Fiat to run on charcoal instead of gasoline, offering a cheaper alternative amid fuel shortages caused by US sanctions https://t.co/dr8jJyR4bE

[Hitomi ✨ moved! @danmeifreak]

"NOT MY CIRCUS NOT MY MONKEYS" IS ORIGINALLY A POLISH PHRASE??????????????????????

[Anshul Kundaje @anshulkundaje]

Excellent post by Rachel Thomas in the ways AI hype is outrunning reality in life sciences

https://t.co/oAqoWaJlIb