Finally I wanted to share a story lead by @DrSagar_Bhattad and colleagues and @VUmedicine student Michael Libre reporting infantile IBD as the presenting symptom of dysbindin deficiency https://t.co/4x9fttY32H
We've also recently published on the clinical and immunological impacts of a novel CTLA4 mutation in a large kindred. Led by @jimmy_maiarana, our multi-talented R38 resident https://t.co/wZMU6RFUK5
Some new work from our lab: We report a novel founder mutation in an isolated population resulting in IL10RB deficiency. This work was lead by @Zhiming_Mao, @mjbetti and also included our 2 undergrads, Shamel Basaria and Kathy Liu https://t.co/OW3WL7kr03
Monogenic autoinflammatory diseases tended to be defined by specific cytokines, such as IL-1b, IL-6, TNF and type I IFN. However, the condition APLAID did not fit, and instead we find that it may be the first of a new category that are caused by G-CSF. https://t.co/1Gf6VIGWVT
A #RareDisease is a disease or condition that affects a small number of people. But, when you look at the big picture, #RareDiseases aren’t so #rare: there are 7,000 rare diseases that impact 300M people 🌍 Learn more before #RareDiseaseDay on 2/28 at https://t.co/iVM4NB4pcw 🧬
@UtzschneiderD A ~5% success rate is sooo dismal. Sorry to hear that. I’m struggling with how much time I spend on grants for competitions that I know have only a 10-15% success rate. Cutting that rate in half is just disheartening.
Recent PhD grads and postdocs looking for a job in industry: a friend is recruiting for this role in Palo Alto CA. Discovery and development of therapies for chronic inflammation. Check it out! https://t.co/0KW5Ozo8hF
Looking forward to seeing my immunology colleagues and hearing these great keynote talks! Registrations are now live for the Southeastern Immunology Symposium
UPDATED: our massive database of PhD fellowships is available for download.
We list 195 different fellowships with description of the award, eligibility criteria, deadline and amount.
Download for free here: https://t.co/1h76jJaHOv
After a grueling diagnostic odyssey - a familiar quest for people living with #RareDisease - Beverly found she has a novel genetic mutation causing a rare Primary Immunodeficiency (PI). Read about her journey to figure out her mysterious illness in this article from @NewYorker.
This is a terrifically written personal account of being affected by a rare genetic disease. This is what drives me to work on inborn errors of immunity. Hoping to solve med mysteries & help patients
Nobody Has My Condition But Me | The New Yorker https://t.co/3u7sZBfn16
Great work by Andrew Patterson to show IEI & IEM share more than previously known--a CRISPR resource for new immunometabolic genes
Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities https://t.co/7EdsoOOkfO
We are in the critical moment of trying to increase participation in the FIRST @GordonConf on sex differences in immunity. If you have data to share or want to learn more, register: https://t.co/8dzdA7FrFF @KleinLab@IghoID
A novel IEI discovered in a collaborative effort spanning scientists from 5 continents, and including 6 unrelated families with the exact same mutation. Congrats @RMBarricarte and coauthors! https://t.co/MMTznW2POY
New work in mice, corroborated with observations of effector T cell behavior in patients with systemic lupus erythematosus, describes the significance of iron in immune cells during autoimmunity. @DoctorKvoss@JeffRathmell @VUMC_VCI https://t.co/JLUMi8kUoL
Hi all, very glad to announce our paper on “Mono- and biallelic variant effects on disease at biobank scale” is now finally published @nature in a set of 7 papers revealing scientific discoveries with @FinnGen_FI. https://t.co/FpDggPBKMG Read on for a twitter summary 1/8
This may have interesting implications for understanding the ‘missing heritability’ in complex diseases. Mom-to-infant and cohabitation effects on microbiome composition. https://t.co/e8BDQLbGES
Gotta respect the dedication required to carry out this 10yr experiment, which yielded some amazing results! T cells just keep going and going and going…
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature https://t.co/jPfmX2Ilrq