Anna-Lena Neehus

Postdoc @bloodgenes @bostonchildrens 🇺🇸 | PhD @casanova_lab @institutimagine 🇫🇷 | Immunologist studying human genetics |

[Anna-Lena Neehus @ALNeehus]

Excited to share our latest work published today in @NatImmunol! 🎉 Together with Taja Vatovec, we investigated how somatic CBL deficiency affects B cell development and function. https://t.co/sROc3oMXX2

[Ofir Cohn @CohnOfir]

Decades of research have revealed the intricacies of how dendritic cells (DCs) function, but fundamental questions remain about how this group of cells develops in humans and how this process goes awry in disease. A thread on our new work! (1/9)
https://t.co/9hgDt3r8n1

[Vijay Sankaran @bloodgenes]

🩸🧬 Dendritic cells are rare but key players in immunity. In a new preprint led by @CohnOfir, we generate a single-cell multi-omic atlas of human dendritic cell differentiation to reveal links to immune-mediated disease: https://t.co/4Q8pA0SykL

[Science Immunology @SciImmunology]

Deficiency in the leukocyte integrin #LFA1 increases susceptibility to commensal human papillomaviruses (#HPVs) by impairing T cell homing and surveillance in the skin. @AhmadYatim_ @casanova_lab @JouanguyE @vahidnezhadlab @BeziatV
https://t.co/C7xfMXKD7q

[TangyeLab @Tangye_Lab]

Latest paper from @Tangye_Lab. A terrific tour de force collab with @Jonathan_Bohlen @ALNeehus @casanova_lab @bloodgenes @DrCindyMa @BustamanteJaci1 & many others. Unravelling the role of CBL in human B cell development/function. Huge thanks to all involved! 🧬🧪🍾 @NatImmunol

[Anna-Lena Neehus @ALNeehus]

Huge thanks to everyone who made this work possible and to @BustamanteJaci1, @casanova_lab, @bloodgenes and @Tangye_Lab for their support and mentorship throughout this journey!
Special shout-out to my friend @Jonathan_Bohlen on his lab's first paper! 🍾

[Anna-Lena Neehus @ALNeehus]

Excited to share our latest work published today in @NatImmunol! 🎉 Together with Taja Vatovec, we investigated how somatic CBL deficiency affects B cell development and function. https://t.co/sROc3oMXX2

[Gaurav Agarwal @GauravA_UK]

What protects some people from leukemia?

Thrilled to share work from the @bloodgenes lab, now published in @Science.
We identify an inherited genetic variant that protects stem cells from blood cancers by reducing risk of CHIP.
https://t.co/ExgWIJQe6y

🧵👇 (1/n)

[Lucrezia della Volpe @dellaVolpe_L]

1/n 📢 🚨 Excited to share that our latest findings from @bloodgenes lab is now out in @NatureCellBio! We discovered that #ferroptosis is a key barrier to #HSC survival during ex vivo culture. 👇Here is the story 👇
https://t.co/US3IoJZB1p

[Peng Zhang @zhangpeng1202]

Attending #ASHG2025 in Boston! Excited that my first PhD student Matthieu @MChaldebas was selected for a presentation on our work detecting 5′UTR variants impacting translation. Great to have @casanova_lab crew here - Clement, Astrid, Gaspard @GaspardKerner, and Anna @ALNeehus.

[Isabelle Meyts @IsabelleMeyts]

PhD position opening in my lab! Grab your chance to dive into the genetics and pathophysiology of inborn errors of immunity and apply!
⁦@FWOVlaanderen⁩ ⁦@ERC_Research⁩ ⁦@Info4PI⁩ ⁦@KU_Leuven⁩ funded, in an international spirit. https://t.co/ACMP5dIDMn

[BogunovicLab @BogunovicLab]

Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of antiviral host genes. How did we choose? Got inspired by patients and gene promoters. Read in detail 👇🏼 https://t.co/uhuhvbZ5KK

[Turvey lab @TurveyLab]

Proud to have worked with Dr. Catherine Biggs and @koborlab to add a new human #InbornErrorOfImmunity to the list!
@GenomeBC @UBC @CIHR_IRSC @CIHR_IHDCYH @BCCHresearch @_HealthyStarts

[Casanova Lab @casanova_lab]

1/ Join us on 24 Sept 2025 at the @InstitutImagine in Paris for the Novo Nordisk Prize Symposium: Inborn Errors of Immunity. Registration is free at: https://t.co/eBCD1HjwGf

[Journal of Human Immunity @jhumimmunity]

Alioua, Rosain @JRosain @hopital_necker and colleagues describe seven intronic pathogenic variants underlying inborn errors of immunity. https://t.co/9o3jcrhlWk

#InbornErrorsOfImmunity

[Vijay Sankaran @bloodgenes]

Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells
https://t.co/nMP5Xd7aEY

🧵 below ...

[Anna-Lena Neehus @ALNeehus]

Very happy to share our review @bloodgenes published today in JHI. We discuss how rare and common genetic variants influence early B cell development and can underlie susceptibility to infectious diseases, autoimmunity and leukemia. 🔬🧬

[Journal of Human Immunity @jhumimmunity]

.@ALNeehus, Neil Romberg, and @bloodgenes review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies https://t.co/X80Z4ZB8IR

[Vijay Sankaran @bloodgenes]

Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by @michaelpoeschla, along with @SashaGusevPosts, @mitchiela, @SharonSavageMD, @hemanth_tummala, and others, published as an advanced online paper in @jclinicalinvest today: https://t.co/pqfe7H1AOx

[Casanova Lab @casanova_lab]

1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis
(https://t.co/30GP2g4st4)

[Science Immunology @SciImmunology]

Scientists have discovered that LY9 deficiency in a subset of T helper cells impairs #interferonγ responses and underlies susceptibility to #tuberculosis in humans. @RockefellerUniv @casanova_lab @MasatoOgishi

Learn more in Science #Immunology: https://t.co/O8VlrQtnwn

[Gaspard.kerner @GaspardKerner]

Thousands of GWAS hits—but how do we link them to biology? 🚨New from Alkes Price group: J-PEP integrates pleiotropy and epigenomic data to reveal shared disease mechanisms across diseases https://t.co/STMgkpoOKl #genomics #Statistics @HarvardChanSPH