@mp_hartmann Thank you!! Our global GRN suggests they function very early on, likely at the progenitor level. It would be interesting to test how perturbing them at that stage influences DC development.
Decades of research have revealed the intricacies of how dendritic cells (DCs) function, but fundamental questions remain about how this group of cells develops in humans and how this process goes awry in disease. A thread on our new work! (1/9)
https://t.co/9hgDt3r8n1
🩸🧬 Dendritic cells are rare but key players in immunity. In a new preprint led by @CohnOfir, we generate a single-cell multi-omic atlas of human dendritic cell differentiation to reveal links to immune-mediated disease: https://t.co/4Q8pA0SykL
Together, this study defines a key and underappreciated role of human DCs in mediating the consequences of inherited genetic variation on a range of complex disorders. (9/9).
Happy to share our recent study investigating the transcriptional landscape of the host when antecedent influenza infection followed by secondary Streptococcus pneumonia infection.
#Influenza#streptococcus#superinfection
https://t.co/BGbxzTSRUu
We are very excited to share our new preprint now on #bioRxiv:
Distinct gene programs underpinning 'disease tolerance' and 'resistance' in influenza virus infection https://t.co/2fbQZ2ZjcX
@vikslab