Jignesh Lodhari

Anjuna Family | Amateur cook | Himalayas & Sea | Hockey | Internal Medicine.

[Prime Minister of Israel @IsraeliPM]

Congratulations, Mazel Tov, my dear friend @PMOIndia @narendramodi, on becoming India's longest-serving elected Prime Minister! 🇮🇱🇮🇳

[Rajveer. @RajveerRVSFan]

First scene aur wo bhi copy lol #Alpha

[Jignesh Lodhari @jignesh17007]

@yrf Lol. Talking about a secret mission in a crowded restaurant. Only u guys can do it. 😂😂😂😂

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.

[Hugh Laurie @hughlaurie]

Thanks for your critique, Janet. We actually tried a couple of episodes where House (Hugh Laurie) (please put the brackets in the right place) gets it right first time, but they were only 6 minutes long. NBC weren’t happy. Then we tried some where House never gets it right and the patient dies. The audience wasn’t happy.

One could apply your trenchant analysis to other art forms: JS Bach wrote 30 Goldberg variations on the same chord structure; Frida Kahlo painted 50 portraits of herself; Henry Moore, what??

The point is, or was, variations on a theme; if all you see is hospital, medical blah blah, then it wasn’t meant for you.

Nonetheless, I look forward to your first novel!

[Jignesh Lodhari @jignesh17007]

I used to buy Davidoff coffee for about 580, n all off the sudden the price everywhere is around 800. Sudden surge!!

[Jignesh Lodhari @jignesh17007]

This is my MAJOR reason I have never ever brought any apple products. They fucking removed the headphone jack.

[The Fourth Musketeer @IV_Musketeer]

.@Apple Planned Obsolescence

The “Truth” about why the headphone jack was removed.

I wonder how much damage has been done to the human brain with bluetooth tech?

[Debabrata Mohapatra @DebabrataTOI]

Arrested, suspended, reinstated & now posted in revenue dept.

Gets another opportunity to ‘earn revenue’

[Jignesh Lodhari @jignesh17007]

@divya_gandotra Feels more like c team, rather the b.

[Lala @lala_the_don]

Real ground report from CJP protest 🔥🤣

[Jignesh Lodhari @jignesh17007]

Hahahaha 😆 😂.

[Gems of Politics @GemsOf_Politics]

So similar 🤣🤣🤣

[Tathvam-asi @tathvamasi6]

He didn’t even hesitate.😜🫡💪🏼💪🏼💪🏼

“Where was the US in this process?”

You must watch for the answer.

Savage 🤣🤣🤣🤣🤣🤣

[AdityaVarma @AdityaVarma45_]

She was literally born to sing this song. 📈🔥

[Harman Singh Kapoor @kingkapoor72]

Carrying a kirpan like this also solves the issue of religious belief.
We don’t need a long and sharp blade to fulfil our need to carry a ceremonial dagger.

[Anand Ranganathan @ARanganathan72]

Starting tomorrow, Supreme court of India is on a six-week summer vacation and will be operating at just 19% of its capacity. There are 53 million cases pending in Indian courts - 93,143 of them are pending in the Supreme Court.

A judge can go on a vacation, a judiciary cannot.

[Jignesh Lodhari @jignesh17007]

@WHOOP @Cristiano Too late brother.

[Jignesh Lodhari @jignesh17007]

New addition to the library- Jonathan Livingstone Seagull.

[Jignesh Lodhari @jignesh17007]

@ZahackTanvir Ed Mubarak brother.

[Abhijit Iyer-Mitra @Iyervval]

You know the Padma awards are the absolute pinnacle of how this government is connected to the ground. If you want to understand why Modi can never be defeated - look at the Padma awardees. All deeply connected to their communities - each one deeply meaningful. ❤️

[Jignesh Lodhari @jignesh17007]

@india_plus_ Its a goast.