Jimmy Doogan

BAYC #1/10,000.

[Jimmy Doogan @jimidoogan]

@nypost What am I seeing?

[Brian Roemmele @BrianRoemmele]

The ultra-fast cancer treatments which could replace conventional radiotherapy.

A pioneering new treatment promises to tackle a wider range of cancers, with fewer side-effects than conventional radiotherapy.

It also takes less than a second.

—

Flash Radiotherapy Cancer Treatment

Recent advancements in cancer treatment have highlighted the potential of Flash radiotherapy, a novel approach that utilizes ultra-high dose rates of radiation delivered in less than a second. This technique aims to improve the efficacy of cancer treatments while minimizing side effects, particularly in sensitive tissues.

Traditional radiotherapy has been a cornerstone in cancer treatment, with approximately two-thirds of cancer patients receiving it at some point. Conventional methods typically involve administering radiation over several minutes, which can lead to significant damage to surrounding healthy tissues and long-term side effects, especially in pediatric patients. The Flash radiotherapy concept, developed by researchers at the European Laboratory for Particle Physics (CERN), seeks to address these limitations by delivering radiation at unprecedented speeds.

Mechanism of Action

Flash radiotherapy operates on the principle of delivering high doses of radiation in a very short time frame. This method has shown promise in preclinical studies, where it was demonstrated that tumors could be effectively destroyed while sparing healthy tissue. The underlying mechanism is believed to involve differential responses of cancerous and normal cells to high-dose-rate radiation, allowing for increased tumor control with reduced collateral damage.

Clinical Trials and Applications

As of now, several clinical trials are underway to evaluate the safety and efficacy of Flash radiotherapy in human patients. Notable trials include:

-Cincinnati Children's Hospital: An early-stage trial focusing on children with metastatic cancer affecting the chest bones.

-Lausanne University Hospital: A Phase 2 trial assessing the treatment of localized skin cancer.

These trials aim to refine the optimal dosing strategies and assess potential side effects, with initial results indicating that Flash radiotherapy may be as effective as conventional methods but with fewer adverse effects.

Particle Selection and Delivery Challenges

One of the critical aspects of Flash radiotherapy is the choice of particles used for treatment. Current research primarily utilizes protons due to their ability to penetrate deep into tissues while being adaptable to existing proton therapy machines. However, the development of new particle accelerators capable of delivering Flash doses using electrons or carbon ions is also being explored, which could expand treatment options for various tumor types.

The future of Flash radiotherapy looks promising, with ongoing research aimed at making this technology more accessible. Efforts are being made to develop smaller, more efficient accelerators that could allow for the widespread implementation of Flash treatments in standard clinical settings.

This could potentially revolutionize the treatment landscape for complex cancers, such as glioblastoma, which currently have limited treatment options.

Flash radiotherapy represents a significant advancement in the field of oncology, offering the potential for more effective cancer treatments with reduced side effects. As clinical trials progress and technology evolves, this innovative approach could transform the standard of care for cancer patients worldwide.

---

Paper: https://t.co/yF2RAeCRyH

[The Knowledge Archivist @KnowledgeArchiv]

Mark Twain held a pistol to his head.

But he couldn’t bring himself to pull the trigger.

So, he put down the pistol and picked up a pen…

Many textbooks portray Mark Twain as poised, self-assured, and composed.

However, the Twain described in writings from 1865 and 1866 is far from that man…

At this time, Twain was living in San Francisco and earning $100 a month writing 2,000-word columns, 6 days a week for a newspaper called the Territorial Enterprise.

The 29-year-old Twain was struggling immensely. He was drowning in debt. The local pawnshops owned nearly all his possessions.

In a letter from 1865, he wrote to his brother:

“If I do not get out of debt in three months – pistols or poison for one – exit me,”

And he nearly took the first option.

There are many stories about what exactly made him change his mind:

One story describes how his eyes met a bill for coal he had received. The wording on the bill was so peculiar for such a low sum of requested money that it made him do a double take. It supposedly brought about a chuckle and he reflected on the oddity of life, putting down his pistol.

Some accounts claim that when he brought the pistol to his head, he couldn’t bear to pull the trigger out of his thoughts of cowardice.

Whatever the truth may be, we do know that the great literary figure had some very dark days in his lonely San Francisco apartment…

Shortly after this incident, Twain hit his first home run. He finally leaned into his inclinations of humor with The Celebrated Jumping Frog of Calaveras County.

It was a humorous work and was published by the New York Saturday Press on November 18, 1865. It brought him his first taste of international fame.

And the rest is history!

USEFUL KNOWLEDGE:

- The Brightest days often come right after the darkest nights.

Life is very strange. In many ways, it is like a video game, in the sense that it is full of tests. Things get extremely hard in life and as long as you hang on and keep pushing, you will make a breakthrough and get to the next level. It's always hardest right before a significant breakthrough. Then things are great for a while but eventually, the pattern repeats itself. The tests vary in difficulty but they all push the individual to ascend to higher levels of consciousness and character.

This story of Twain’s dark days displays the idea perfectly. He was in just about the lowest place a person can be, yet he didn’t let go of himself and as a result, very quickly got his first big win.

I’m sure you can relate to this story in some way - reflecting on your own difficult times. Hopefully, the video game analogy provides you with a greater awareness of the pattern.

So, when things get dark, hold on, keep pushing and bright daylight will come soon enough.

[Angry Tom @AngryTomtweets]

ChatGPT is old news.

AI Chrome extensions are now leading the way.

Here are 8 insane AI Chrome extensions to save hours of work: 👇

[Alvaro Cintas @dr_cintas]

BREAKING: Code Interpreter will be available to all ChatGPT Plus users over the next week!

It can analyze data, create charts, edit files, perform math & much more.

Here are 10 mind-blowing examples of what is possible:

[Parker Worth ⚡️ @parkerworth]

The most profitable skill in 2023:

Storytelling.

But most people don't know how to start.

Steal these 10 lessons to make your stories sell:

[Madni Aghadi @hey_madni]

ChatGPT is free “Harvard University”.

But only 0.1% of people can prompt it well.

Here are Top 22 Tips to unlock its full potential: 🧵

[Nathan Baugh @nathanbaugh27]

Harry Potter is the #2 best-selling book of the last quarter century.

Only behind The Bible.

And JK Rowling used 1 storytelling framework for the entire series.

Here’s a breakdown:

[Abhishek @HeyAbhishek]

Al content writing tools You can't Miss:

1. ChatGPT - Research
2. Hemingway - Clarity
3. Hypefury - Content Creation
4. Quillbot - Sentence enhancer
5. Grammarly - Write mistake free
6. Writesonic - Write copy 10x faster
7. Power Thesaurus - Synonyms/Antonyms

What else?

[Jon Brosio @jonbrosio]

How to build a $2000/mo membership site for $0

(Even if you have a small audience)

A simple guide to get you started:

[Clintin Lyle Kruger @Lyle_AI]

ChatGPT is a master copywriter.

But most people don't know how to leverage its existence.

Here are 10 prompts to writing engaging copy using ChatGPT 👇

[Codie Sanchez @Codie_Sanchez]

People don’t care what you’re doing unless you answer their real question:

“What’s in it for me?”

19 other uncomfortable business truths:

[Colin Keeley @ColinKeeley]

Bryan Johnson spends $2 million a year to be 18 years old again.

In 2021, he reduced his epigenetic age by 5.1 years in 7 months (a world record)

His 13-steps for a long healthy life:

[Tulsi Soni @shedntcare_]

AI Tools are the next big thing in AI.

Here are the 27 insane New ChatGPT Alternatives start earning $5,000/mo with AI:

1. https://t.co/R3nGdcZf6g - ChatGPT for Documents
2. https://t.co/AdSsMPkdXy - AI Clip creation Tool
3. https://t.co/aJxJUqFL6N - Generate AI Music
4. https://t.co/LfbW0PggU9 - AI Meeting Summarizer
5. https://t.co/xfetC0lMC2 - AI Voice Generator

[Parker Worth ⚡️ @parkerworth]

In 2022, Hollywood made $7,320,000,000 through storytelling.

99% of the movies used the same story framework.

Here’s a breakdown (including clips from your favorites):

[Shruti @heyshrutimishra]

Companies are paying $375,000 a year for AI prompt engineers.

But most people don’t know how to land the hottest job of 2023.

Here's how you can get one 👇

[Romeen Sheth @RomeenSheth]

"I want to switch careers, but I’ve invested 5 years in the path that I am on and I fear that if I switch now I am going to have to start over. How would you think about this?"

Most people idealize careers as clean linear trajectories. They are not. They are windy, messy and filled with ups and downs.

This is not uncommon. What is common is every person thinking *they are different.*

Why is that important? Well when you think you’re different in this situation, you get stuck:

You don’t want to go backwards and are crippled by some combination of FIRE (fear, insecurity, resistance and ego):

- Fear: “I feel like I am going to fail. I don’t know what I’m doing”
- Insecurity: “I’m not where I am supposed to be at a certain age”
- Resistance: “Am I going to fit in this new environment? Maybe it’s not meant to be”
- Ego: “I know too much and am too good to start over”

But if you internalize this as a common pathway - that careers have peaks, valleys and all sorts of elevation in between - you understand that it is normal to go down to go up. It’s a really freeing insight. Understanding this at its core removes artificial constraints and barriers from your thinking.

More importantly, it focuses you on the right variables to consider in this situation.

If I were making the switch I’d ask four questions:

- Peak: How high can I go?
If I make the switch, what is the potential upside of this new direction? How does it compare to the current direction I am headed for?

- Velocity: How fast can I get there?
If I make the switch, am I set for a slow and long grind or is it a curve that will require deep learning and familiarity, but once I am up to speed I will be able to accelerate on?

Another consideration when you’re thinking about velocity, is consider compounding. At five years into your path, you’re likely just getting to a stage where the benefits really compound. Year 6-8 is not going to be a linear ascent; it could be exponential - so make sure if you’re switching you understand this.

- Endurance: How sustainably can I get there?
Will you personally endure the path for a long period of time? Building on the point about compounding, real gains come when you’re 5-10-15 years into a journey.

Now whenever I think of my involvement in anything - I try to think about if it’s a journey I can see myself lasting on. It turns out you are sometimes your biggest competition.

- Personal Fit: If I get there, how do I feel?
Envision you’ve climbed the mountain top! High fives all around, you’re the man! (or woman!). Do you feel great or do you feel empty?

This is something people spend too little time on in my opinion. The worst thing in life is playing the wrong game. Make sure you give some thought to how you might feel if what you set out to accomplish came true.

[Angry Tom @AngryTomtweets]

RIP website designers.

In 90 seconds, AI can build you a professional website.

Here's how you can create professional website with AI in seconds:

[Robin Delta @heyrobinai]

ChatGPT is a FREE employee.

But most people don't know how to unlock its full potential.

Here are 6 Prompts that nobody knows to be 10x more productive.

[Saumya Singh @saumya1singh]

Remote work is the future.

Here are websites offering $700 to over $1,500 per month work.

Don't miss out: