JJoale

[JJoale @jjoale_]

@Rothmus Yeah well it doesnt work

[JJoale @jjoale_]

@Bitcoin_Teddy So what does it do?

[JJoale @jjoale_]

Ei tietenkään! Siis yritän hakea tässä sitä punaista lankaa jutusta ja sillä asiaa kommentoinkin.

Tällä hetkellä kun ketju näyttäytyy about näin: "nikotiinin käyttäjät roskaavat luontoa, olisi parempi kun he siirtyisivät käyttämään nikotiinia eri tavalla".

Oletan ettei tämä ollut se pääpointti tässä? Mutta mikä oli?

[JJoale @jjoale_]

Juu, näinhän se usein on.

Tää nyt varmaan on ragebaittia mihin meen vastaamaan mutta edelleenkään (tai varsinkaan nyt) ketjussa ei oikein oo mitään järkeä?

Ja niinkun sanoit, usein häiriökäyttäytymistä liittyy näihin kuten:

Jotkut nikotiinia käyttävät nakkelee tuotteensa luontoon ja se ongelma ei ratkea vaihtamalla nikotiinituotetta toiseen.

Jotkut amfetamiinia käyttävät ryöstelee lähikauppoja ja se ongelma ei ratkea vaihtamalla katupiriä apteekkipiriin.

Jotkut alkoholia juovat hakkaavat vaimonsa kännipäissään ja se ongelma ei ratkea vaihtamalla viinaa kaljaan.

Eli edelleenkään en yhtään tiedä mitä yrität ketjussa sanoa? Ellei tosiaan kyseessä ole vaan ragebait.

[JJoale @jjoale_]

@mattimolari Mitä yrität sanoa? Tässä ketjussa ei nyt tunnu olevan oikein järkeä?

Nikotiinipussit ja tupakantumpit päätyvät luontoon kun jotkut k-päät niitä sinne heittelee. Ei sen takia että he käyttävät nikotiinia. Miten ajattelit että purkat ja laastarit poistavat ongelman?

[JJoale @jjoale_]

True. But also in Finland, those things are bullshit also.

Low corruption -> corruption doesnt count because its just "maan tapa". So we have corruption but we dont call it that so it looks good in stats.

Functioning institutions -> what institutions function well? Public, free-to-use yeah but well-functioning not so much.

Physical safety -> good for now, but going into bad direction

Trust in government -> probs because finnish culture is like that and we're kinda stupid regarding this, our government doesnt give any reason to trust it tho

[JJoale @jjoale_]

@DonAlt https://t.co/8UVmGgOVTB

Important pastas here

[Big D @bigdsenpai]

A public service thread:

important CT copypastas for those who have forgotten to save them

🧵👇🍆

[JJoale @jjoale_]

@nadoHQ Few invites:
https://t.co/Lqcr4CF5V8

[JJoale @jjoale_]

@nadoHQ Invite codes if someone needs
https://t.co/Lqcr4CEy5A

[JJoale @jjoale_]

@grok @VuorinenSamppa @klaus_koo Tähän keskusteluun liittyen, listaatko vielä todennäköisiä syitä miksi joidenkin ihmisten on vaikea ymmärtää bitcoinin arvonlupausta? Vaikka asia on helpostikin selitettävissä muutamalla lauseella kuten olet tässäkin ketjussa tehnyt.

[Martin Sellner @MartinSellner_]

The Danish army conducted IQ tests, then grouped the results by first name.

In 2015, globalists claimed there will be high quality and educated migrants. The reality is different.

[Paul F. Austin @PaulAustin3w]

We can now watch psilocybin grow new brain connections in real time.

Not metaphorically. Not "neuroplasticity" as a vague buzzword. Actual, physical structures — dendritic spines — sprouting from cortical neurons within 24 hours of a single dose.

A team at Yale used chronic two-photon microscopy to image individual dendritic spines on layer 5 pyramidal neurons in the medial frontal cortex of living mice.

Before psilocybin. After psilocybin. Same neurons. Same spines. Day after day.

And here's what they found:

A single dose of psilocybin produced a ~10% increase in spine density and spine size. New spines began forming within 24 hours. Most of these new connections were still there a month later.

That last part matters most.

Psilocybin has a half-life of about 3 hours. The molecule is gone by dinner. But the structural changes it triggers persist for at least 34 days (and likely far longer).

This is the biological explanation for something clinicians have observed for years: a single psilocybin session producing therapeutic benefits that last months. The drug disappears, but the architecture it built does not.

There's a critical mechanistic detail. When researchers pre-treated with ketanserin — a 5-HT2A receptor antagonist — the spine growth was completely blocked. This confirms that structural remodeling depends on activation of the serotonin 2A receptor. The same receptor responsible for the psychedelic experience itself.

A 2025 follow-up from the same lab went further. Using rabies tracing to map brain-wide inputs to these new spines, they discovered psilocybin's rewiring is network-specific. It selectively strengthens inputs from perceptual and default mode network regions, the same networks implicated in self-referential processing, rumination, and depression.

It doesn't just grow connections randomly. It grows the RIGHT ones.

Here's what this means for practitioners:

The window after a psychedelic experience isn't just psychological. It's structural. New dendritic spines form and stabilize in the days and weeks following a session.

Integration practices — therapy, journaling, somatic work, meditation, breathwork — aren't just processing insights. They may be reinforcing which of these new physical connections survive.

You're not just supporting someone's mental model. You're supporting their neural architecture.

Think about what that reframes. The integration period isn't a nice-to-have. It's a biological imperative. Those new spines either stabilize into lasting connections or get pruned. The environment, practices, and support during that window may determine which.

We're not just learning that psilocybin works. We're watching exactly how it works, at the level of individual synapses.

The implications for how we design protocols, structure integration, and time follow-up sessions are enormous.

What do you make of this research? Is psilocybin the miracle drug that science makes it out to be?

[Matt Shumer @mattshumer_]

https://t.co/ivXRKXJvQg

[JJoale @jjoale_]

@maruushae @insiliconot Block heaters, water heaters, webasto, eberspächer. Any of those make cold starting way easier. Well technically its not cold starting after using any of those but anyway. Last night -28 also in here, 20min with block heater and starts like a charm.

[JJoale @jjoale_]

Idk how things are done there but atleast in finland we dont have flow at all times, only when tap is opened in house. But yeah, doesnt even need to go deep underground for pipes to work. At house pipes goes in places that are warm enough to not freeze. Normally at least. We dont and our pipes freeze normally multiple times during winter, but im just lazy to do anything about it, i just melt them if/when those freeze

[JJoale @jjoale_]

True.

BUT i think @loraclexyz has an error with thinking "all the narratives have been tried". It always feels that way until some degen comes up with an idea/product that makes few millionaires in a short amount of time and that leads into a new narrative.

That said, this might be an error in my thinking and we have infact tried everything. Just hard to imagine that space like this cant spark greed in people.

[Ian Proud @proud_diplomat]

This is the most idiotic post I have seen this year (and there has been a lot of choice).

Securing control of #gas supply, in fact, means restricting it, and raising prices.

Strengthening #autonomy, means #dependence on expensive US supplies.

@EP_President is brainless.

[Alex (Sasha) Krainer @NakedHedgie]

EU drilling deeper and deeper depths of suicidal madness, all gloating and hi-fiving as they go... Simply INSANE!

[JJoale @jjoale_]

@insiliconot Ur candles are broken

[JJoale @jjoale_]

@PetteriHaveri @TinoAalto "Syynä muutokseen on Luken mukaan uusin käyttöön otettu tutkimustieto."

No eiköhän tämä näille "alustan hönöille" ollut jo aiemmin päivänselvä asia että Luke toimitti aiemman tutkimuksen tulokset ideologisista syistä eikä realismiin pohjaten.