Jacopo Marazzato MD PhD

Cardiac Electrophysiologist and Research Scholar @MonteHeart

[Europace Editor-in-Chief @EuropaceEiC]

🚨Latest #Europace #EPeeps

Application Repetition and Electrode-Tissue-Contact Results in Deeper Lesions Using a #PFA circular catheter

📚👉 https://t.co/CqIobxkOIG

@GiulioConte9 @FraSantoroMD @marcovitoloMD @Dominik_Linz @MBergonti @AndyZhangMD @LuigiDiBiaseMD @natale_md

[All About AFIB @afib_news]

🔥🔥🔥EUROPACE: Application Repetition and Electrode-Tissue-Contact Results in Deeper Lesions Using a Pulsed-Field Ablation Circular Variable Loop Catheter @EuropaceEiC @BorianiGiuseppe @LuigiDiBiaseMD @AndyZhangMD @dogi84md @marcoschiavone5 @tondo_claudioMD @DJ_Lakkireddy @aalahmadmd @jmarazzatoMD

🔬 New Research Alert! A breakthrough study demonstrates that both application repetition and increased electrode-tissue contact significantly enhance lesion depth during Pulsed Field Ablation (PFA), a cutting-edge treatment for cardiac arrhythmias. 🫀 #Cardiology #PFA

📊 Key Findings:

•In the porcine model, lesion depth increased from 3.5 ± 0.7 mm with a single ablation to 4.4 ± 1.3 mm when two ablations were applied. This significant improvement underscores the importance of repeating the energy applications. 📏
•Contact force was another critical factor. When high contact force was applied, the lesion depth reached 6.5 ± 0.7 mm with six stacked ablations, demonstrating a clear correlation between force and lesion effectiveness. 💪 #HeartHealth

🌱 Vegetal Model Insights:

•The study also utilized a vegetal potato model to further explore the impact of contact force. Lesion depth varied dramatically with the amount of contact force applied, ranging from 0.6 ± 0.5 mm without contact to 7.3 ± 0.9 mm with maximum force and six stacked ablations. This suggests that higher contact forces lead to deeper and more effective lesions, even in a controlled bench-top setting. 🌍 #MedicalResearch

🔍 Contiguity of Lesions:

•Achieving contiguous lesions between electrode spaces was another crucial outcome. The study found 100% lesion contiguity on the potato model when 30g of contact force was applied, highlighting the importance of proper catheter contact for complete lesion formation. In the porcine ventricular model, lesion contiguity ranged from 68% to 93% with similar improvements noted with increased contact force. 🚀 #InnovationInMedicine

💡 Clinical Implications:

•These findings suggest that the effectiveness of PFA is closely tied to the biophysical parameters of the procedure, particularly application repetition and contact force. This challenges the traditional focus on mere electrical signal attenuation as the primary endpoint for successful ablation. Clinicians may need to consider these factors more carefully when performing PFA to optimize outcomes for patients. 🧠 #CardioCare

🔧 Technological Insights:

•The study also examined the use of the Tissue Proximity Indication (TPI) feature in the VLCC catheter, which helped ensure adequate tissue contact during ablation. The results showed that positive TPI correlated strongly with lesion contiguity, making it a valuable tool for clinicians during PFA procedures. ⚙️ #MedicalTech

📈 Future Directions:

•As PFA technology continues to evolve, this study provides a foundation for future research. Understanding the precise relationship between contact force, application repetition, and lesion depth will be crucial in developing more effective ablation strategies. Moreover, further studies in human models will be necessary to validate these findings and refine PFA protocols. 🔬 #FutureOfMedicine

🔗 For a deep dive into the full methodology, data, and results, check out the study here: https://t.co/N97ww107hN

[Luigi Di Biase @LuigiDiBiaseMD]

Can we predict lesion depth with PFA and therefore guide the number of applications reducing haemoglobinuria? Yes with the PFA index In press @CirculationEP @AndyZhangMD @BiosenseWebster @jmarazzatoMD @natale_md @GrupposoVito @MontefioreNYC @MonteHeart
https://t.co/cjoBqEEZ4v…

[Luigi Di Biase @LuigiDiBiaseMD]

We just published a different way: PFA index. It can predict lesion depth and guide number of applications @CirculationEP @GrupposoVito @AndyZhangMD @MontefioreNYC @MonteHeart @HRSonline @EHRAPresident @ESC_Journals @natale_md @BiosenseWebster
https://t.co/cjoBqEEreX…

[Nilarun Chowdhuri @NilarunC]

Lesion assessment in catheter ablation for atrial fibrillation - Is Contact Force necessary for PFA?

@AFSymposium 2024 Boston with Professor @LuigiDiBiaseMD HiroshiNakagawa davidhaines

[Jacopo Imberti @JacopoImberti]

📚Must read review for ALL cardiologists!
🎯Very precise and practical

💊Antithrombotic Therapy for Patients Undergoing Cardiac Interventional Procedures

🖇️ https://t.co/A7Y3DWEkjH

👏@LuigiDiBiaseMD @jmarazzatoMD @JorgeERomeroMD @DrRachitaEP @JACCJournals @ACCmediacenter

[Xiaodong Zhang (Andy), MD, PhD, FHRS, FACC @AndyZhangMD]

Congrats to @LuigiDiBiaseMD and team! A practical guide for AC management in the setting of interventional procedures.
#EPeeps #CardioTwitter
@MonteHeart @MontefioreNYC @EinsteinMed @CardioMDPhD @natale_md @jmarazzatoMD @DJ_Lakkireddy @VelascoCardio

[JACC Journals @JACCJournals]

Decisions regarding antithrombotic therapy in pts undergoing interventional or #cvEP procedures have become a crucial part of best practices.

Expert group provides a practical guide for peri-procedural antithrombotic mgmt across #Cardiology. https://t.co/9bfdjQbVFk #JACC

[Vassil Traykov @TraykovVassil]

Antithrombotic Therapy for Patients Undergoing Cardiac Electrophysiological and Interventional Procedures: JACC State-of-the-Art Review | Journal of the American College of Cardiology https://t.co/FNQUU3FYGD

A very interesting and insightful review by @LuigiDiBiaseMD
👇

[Xiaodong Zhang (Andy), MD, PhD, FHRS, FACC @AndyZhangMD]

#EPeeps
Our Paper on Point-by-Point #PFA is featured as Editor’s Choice in the latest issue of #CircAE. Congrats to @LuigiDiBiaseMD and everyone on the team.

👉 https://t.co/peZUJ0IrOr

@jmarazzatoMD @JasperZouMD @NilarunC @GrupposoVito @natale_md @MonteHeart @EinsteinMed

[Xiaodong Zhang (Andy), MD, PhD, FHRS, FACC @AndyZhangMD]

ULS FAM!
New feature of CARTO 3 V8!
Look at the video of the autogenerated machine-learning 3D map using CARTOSOUND FAM with only ICE catheter.
Check our paper #Europace👉 https://t.co/FLjoncPrDw
@LuigiDiBiaseMD @JasperZouMD @dogi84md @GrupposoVito @NicoTarantinoMD @natale_md

[Jacopo Marazzato MD PhD @jmarazzatoMD]

Fresh off the press on @pace_journal our review on pseudo-pacemaker syndrome with the case report of the longest PR interval to date! Thank you Prof @LuigiDiBiaseMD for including me in this amazing project @MonteHeart

https://t.co/sSu1dzocyH

[Jacopo Marazzato MD PhD @jmarazzatoMD]

Fresh off the press on @pace_journal our review on pseudo-pacemaker syndrome with the case report of the longest PR interval to date! Thank you Prof @LuigiDiBiaseMD for including me in this amazing project @MonteHeart

https://t.co/sSu1dzocyH

[Europace Editor-in-Chief @EuropaceEiC]

#EUROPACE_FRESH_OFF_THE_PRESS

👏Kudos to the authors

📌Feasibility of a novel 3D artificial intelligence algorithm integration with ICE for LA imaging during AF ablation.

🧐https://t.co/BRLzRSFp1A

@escardio @GiulioConte9 @marcovitoloMD @Dominik_Linz @AndyZhangMD @FraSantoroMD

[Xiaodong Zhang (Andy), MD, PhD, FHRS, FACC @AndyZhangMD]

Our new research has been published in #Europace. Congrats to Professor @LuigiDiBiaseMD and everyone on the team. 👏👏👏 @JasperZouMD @natale_md @GrupposoVito @jmarazzatoMD @NicoTarantinoMD @dogi84md @EuropaceEiC @MonteHeart @MontefioreNYC @EinsteinMed

✍️https://t.co/3qj3ypV4rq

[Jacopo Marazzato MD PhD @jmarazzatoMD]

Fresh off the press our editorial with Prof. Di Biase @LuigiDiBiaseMD in @EuropaceEiC
on long-term outcomes of hybrid ablation for persistent and long-standing Afib by Pannone et al from @UZBrussel
Congratulations to all authors! @deasnostos https://t.co/QExlHK6Lp8

[Europace Editor-in-Chief @EuropaceEiC]

#EUROPACE

#Editorial
by @LuigiDiBiaseMD & Jacopo Marazzato

Hybrid ablation for persistent and long-standing persistent #AFib: is the grass really greener on the other side?
📖https://t.co/DUNnMFWoj2

@GiulioConte9 @Dominik_Linz @marcovitoloMD @AndyZhangMD @FraSantoroMD

[Jacopo Marazzato MD PhD @jmarazzatoMD]

Fresh off the press our editorial with Prof. Di Biase @LuigiDiBiaseMD in @EuropaceEiC
on long-term outcomes of hybrid ablation for persistent and long-standing Afib by Pannone et al from @UZBrussel
Congratulations to all authors! @deasnostos https://t.co/QExlHK6Lp8

[Jacopo Marazzato MD PhD @jmarazzatoMD]

How to manage atrial arrhythmias after lung transplant @LuigiDiBiaseMD
@MatthiasEikerm1
@MonteHeart https://t.co/t9HLhcu55n

[JICE @JICE_EP]

🚨New #FreeRead Article in
@JICE_EP

Outcomes of Catheter Ablation of Atrial Tachyarrhythmia Guided Exclusively by Activation Mapping

by @AndyZhangMD @dogi84md @Dr_Santangeli @DJ_Lakkireddy @natale_md @LuigiDiBiaseMD

📖☕️ #FreeRead:
https://t.co/ICu7PADLpI

#EPeeps @EPeeps_Bot