Jordan Minnell

Research Fellow. Girl Dad. Part of the RNAissance. @malaghan_inst, ex- @ImperialInfect 🇳🇿🧬 🦠 🧪

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Optimization of a liver Trm cell-inducing mRNA vaccine by reduction of type I interferon response
https://t.co/cdzUzy0yQ1 🇳🇿

[Jake Scott, MD @jakescottMD]

1/ Tucker Carlson: “Do you think overall the COVID vaccine killed more people than it saved?”
RFK Jr: “The truth is, I don’t know.”

This is outrageous.
I do know.
The answer is: unequivocally no. 🧵

[Trevor Campbell @TrevorCampbell_]

There are so many weird Biology quirks that I somehow missed before and am only just finding now...

Apparently translation can and *does* initiate from EVERY codon

With the caveat that any codon other than the canonical AUG / GUG / UUG options induce transcription at such wildly inefficient rates that they are nearly undetectable

But they DO happen 🤯

I wonder what weird and rare products might be floating around in our bodies, some of which might even be really important

[Jason Luke, MD, FACP, FASCO @jasonlukemd]

Extremely excited re: IMA203 - PRAME TCR T cells Ph 1 study published in @NatureMedicine! This is a transformative Rx in #melanoma for HLA-A201+ & PD1 refractory pts. Compared to TIL, easier to make, less toxic & so far ~2x response rate in heavily pre-Rx.
https://t.co/HVgl1QRQfQ

[Dr. Lucky Tran @luckytran]

Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines.

When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.

[Jordan Minnell @Jminnell]

@PeacockFlu Killing it Tom! Well done mate

[Nature Reviews Methods Primers @MethodsPrimers]

mRNA vaccines produce rapid and precise immune responses against infectious diseases and cancers.

Check out this Primer for details on the development of nanomaterials for mRNA vaccines and how they are designed: https://t.co/PmeYGmjfIi

[Dr. Shubham Misra शुभम मिश्रा🧠⚛️🇮🇳🇺🇸 @Shubham_Neuro]

Fresh PhD Student 5th year Postdoc
#AcademicChatter @PhDVoice

[Jordan Minnell @Jminnell]

@AdamRutherford During London lockdown I added 2 large bottles of rum to place-hold the minimum price for delivery… forgot to add anything else in time

[Jordan Minnell @Jminnell]

@GYamey 😳

[Jordan Minnell @Jminnell]

@ENirenberg @TheDrJon 😂 omg - absurdity

[Daniel Goldhill @influenzal]

Is there anyone out there looking for an HFSP grant but doesn't have a friendly virologist to apply with?
My last year as a new-PI so I would love to apply with other new-PIs.
V interested in bio, chemists or AI new-PIs anywhere but Europe!
Please write and we can talk ideas!

[Michael Mina @michaelmina_lab]

Measles does more than just the acute infection

It can wipe out large swaths of acquired immune memory by directly destroying the memory B cells, plasma cells, and T cells - causing people to become susceptible to infections they should be immune to:

https://t.co/zbsHKmNnFW

[Jordan Minnell @Jminnell]

@likai_tan Any reason to expect super highly activated CD8s? I’ve seen these pops move around (I.e downregulation of CD8 expression in instances where the CD8s have been really *really* activated. You would also see TCRb or similar down regulated.

[Jordan Minnell @Jminnell]

@GapinLaurent @amitava_immuno @HannahVMeyer @CarcySalome Cool! I have a question, has your team looked at these equivalent populations in mouse models?

[Jordan Minnell @Jminnell]

@MaillardLab @VanderveenLab @TheKennedyTrust @blizard_inst @QMUL Congratulations!

[Anna Blakney @AnnaBlakney]

Excellent article by @ElieDolgin on the recent approval of the Arcturus saRNA vaccine! As @nathanielswang of @Replicate_Bio put it, it's incredibly validating for the field 😀 Self-copying, self-amplifying, self-replicating, tomato, tomato...

https://t.co/i6q7zYKtQN

[Jordan Minnell @Jminnell]

@fredlau1101 I reckon this will be concatenated - I’ve been suprised a lot recently with ONT data

[Brian Groom @GroomB]

A football match in 1599 between men of Bewcastle, England, and Armstrongs of Whithaugh, Scotland, was followed by ‘drynkyng hard’. Final score was two dead, 30 taken prisoner ‘and many sore hurt, especially John Whytfeild, whose bowells came out, but are sowed up againe’. 1/5

[Imperial Department of Infectious Disease @ImperialInfect]

Join us for our next Infection and Immunity Seminar with @Jminnell @Malaghan_Inst.

He will discuss mRNA vaccines against malaria tailored for liver-resident memory T cells.

🗓️7 Nov, 12:30 - 13:30
📍St. Mary's Campus/Online

Find out more 👉 https://t.co/LqLV42JR9U