JohnAllenBio

Going founder mode on #CFS #MECFS #longcovid

[JohnAllenBio @johnallenbio]

@TWestphalia @jason_isaia @mitodicure They’re not even starting clinical trials now. This is nothing to hang our hats on at all.

[JohnAllenBio @johnallenbio]

Why do I think #MECFS and #Longcovid are #mitochondria based?

Because of persistent fatigue. That is the defining symptom. PEM is usually intermittent, fatigue is always.

Mitochondria make 95% of our energy through the Krebs cycle. And that seems ot be what's broken.

[JohnAllenBio @johnallenbio]

If anyone knows a physician who would consult for my Youtube channel I would greatly appreciate it

For example: I want to try using an oxygen machine and see if that affects ATP, HRV and subjective energy/wellbeing. Want to do so safely. Appreciate any referrals!
#cfs #longcovid

[JohnAllenBio @johnallenbio]

And gone. Short term fix for energy and contentment

[JohnAllenBio @johnallenbio]

Glutamine spikes my #hrv every time. #glutaminolysis #cfs

[JohnAllenBio @johnallenbio]

@JackHadfield14 The bottleneck is having to actually test things in humans to confirm whether or not our predictions are safe/true or not.

[JohnAllenBio @johnallenbio]

Why I'm going #foundermode on #cfs

https://t.co/P7UxOwhX3s

[JohnAllenBio @johnallenbio]

@HazylightsSa Everyone is fatigued though, right? Is that not exertional intolerance?

PEM is intermittent, is it not? I think there's also more to the story FYI

I think there could be overfocus on PEM and not enough on the fatigue. It's called chronic fatigue syn and not PEM syn for a reason

[JohnAllenBio @johnallenbio]

@bhanlon15 Will this be publicized or the results therefrom? If so, how so?

[JohnAllenBio @johnallenbio]

@joannamoncrieff Why not come up with other solutions or find the actual problem instead of complaining about something that actually helps people, some of the time?

Even placebo effects can be helpful assuming that is all that is happening.

And we know how bad SSRIs are for people

[JohnAllenBio @johnallenbio]

@joannamoncrieff List one thing prescribed for depression that doesn't.

[JohnAllenBio @johnallenbio]

After taking some supplements I feel a tingling in my body, usually on the back of my body like upper back and shoulders. Almost always on my backside.

I think this is ATP being produced. Yet another thing I'm going to test in my lab

#cfs #longcovid

[JohnAllenBio @johnallenbio]

"Physiological concentrations of cyanide stimulate mitochondrial Complex IV and enhance cellular bioenergetics"

https://t.co/8GVpyuFUQE

[JohnAllenBio @johnallenbio]

Probably the craziest thing I've learned since researching cfs and #mitochondria is the fact that the right, but very small (0.1-nM to 1-µM) amount of cyanide stimulates mitochondrial energy production (IV). Also we already have tiny amounts in our bodies.

NOT MEDICAL ADVICE

[JohnAllenBio @johnallenbio]

Something that sucks is that some interventions for #cfs could be having a positive effect, but we don't know bc they're very slow and we're not repeatedly testing our #mitochondria

1 thing I will be testing on my Youtube channel
Follow along to see the tests

YT @johnallenbio

[JohnAllenBio @johnallenbio]

I'm convinced that our bodies make #ATP overnight and that the reason for unrefreshing sleep is that our mitochondrial respiration is broken and thus we make less overnight.

And when I sleep longer/better than normal I feel much better, but only for an hour or so...

[JohnAllenBio @johnallenbio]

If I sleep really well sometimes in the morning I feel sort of ok for an hour or so.

Then after climbing the stairs a few times and getting the kids ready it's back to normal fugue/fatigue state. ugh.
#cfs

[JohnAllenBio @johnallenbio]

@tessfalor @liamsLCjourney Can’t wait to get your thoughts @tessfalor !

[JohnAllenBio @johnallenbio]

@tessfalor @liamsLCjourney Most of the way done with a video about this subject but my brain also isn’t working well enough to edit the thing.

[JohnAllenBio @johnallenbio]

@liamsLCjourney Would love to gather more though. This would be quite helpful for research purposes. #mitoswab

[JohnAllenBio @johnallenbio]

@liamsLCjourney All of the mitoswab results on here are pretty bad. RNA is not the full picture unfortunately. That tells us about gene expression not the current state of our mitochondria. The Krebs cycle is unfortunately very complex; lots of things could be wrong.

[JohnAllenBio @johnallenbio]

@elizaclove I haven’t even tried because I know it would be such a pain in the ass and there is only so much they can do anyways.