Jonathan Edwards

Asst Prof @ChildrensPhila and @CHOP_Research | Pediatric Heart Failure/Transplant Cardiologist | Basic/Translational Scientist #RVFailure

[Jonathan Edwards @JonEdwardsMD]

Super excited to share our new paper from an amazing team!
“Human adult and pediatric multimodal transcriptomic atlas of progression from pressure-loaded to failing right ventricle” @AranyLab @IvanKuznet @YonathanAberra #singlecell #rightventricularfailure #RVfailure https://t.co/LU3N7eBowZ

[Jonathan Edwards @JonEdwardsMD]

Excited to share our work showing that ROR2 regulates proteostasis in cardiomyocytes, with excess ROR2 disrupting cardiomyocyte structure leading to RV failure!
#Circulation #RVFailure
https://t.co/wHgC1Jm6rM

[Ivan Kuznetsov @IvanKuznet]

Thank you to co-author @itskristinali and senior authors Jonathan Edwards and Zolt Arany @AranyLab. Also to @patrick_ellinor for helping with snRNA-seq, @LavineLab for pediatric data, Kenneth B. Margulies for adult samples, @PennCVI, and many others.

[Ivan Kuznetsov @IvanKuznet]

The result: most transcriptional changes happen before failure. While function is still preserved, the myocardium is already far from “normal.”

More broadly, I think this challenges the idea that RV failure is simply accompanied by progressively greater transcriptional changes.

[Jonathan Edwards @JonEdwardsMD]

https://t.co/nLat00CT3S

#penguinrevolution

[Jonathan Edwards @JonEdwardsMD]

Proud of @iamcoraledwards! — check out the awesome work of some Mom-preneurs in Philly https://t.co/icCwuSpG2w #mompreneur #Philly #leadershipcoaching

[Jonathan Edwards @JonEdwardsMD]

@LongShengSong1 @qianshi_uiowa @IntMedatIowa @UIowaACRC Massively parallel low throughput proteomics

[Long-Sheng Song @LongShengSong1]

The Grand Master of Western Blotting @qianshi_uiowa. Feel so good when you walk by and see this in the lab. @IntMedatIowa @UIowaACRC

[Diwakar Turaga @DiwakarTuraga]

Wonderful meeting by @AdditionalVent on single ventricle research - from zebrafish to VADs. Connecting folks including three young pediatric cardiology physician scientists and their role model @dquiat @JonEdwardsMD @dsrivastava_md #SVIM2022 #singleventricle

[Children's Hospital @ChildrensPhila]

We're proud to share the launch of a new research institute: The CHOP Cardiovascular Institute, led by Dr. Daniel Kelly, Director of the @PennCVI, will develop novel research programs & drive scientific discovery to improve pediatric cardiovascular care: https://t.co/Q29y3ypugn

[The Arany lab @AranyLab]

Proud to be part of new @ChildrensPhila Frontier Program: Advanced Cardiac Therapies for Heart Failure Patients. co-PI with Joe Rossano, Katsuhide Maeda. Major involvement from @JonEdwardsMD. Research focus on understanding the enigmatic right heart failure..

[JAHA @JAHA_AHA]

Novel validated risk score predicts mortality of ED VAD patients using identifiable demographic and clinical factors @JEdelsonMD #AHAJournals https://t.co/oRQ0iXFqHb

[JAHA @JAHA_AHA]

Edelson and colleagues characterize the growing financial burden, and high risk of death, of ambulatory VAD patients presenting to the ED. https://t.co/UlBoAEm9xh @JEdelsonMD #AHAJournals

[The Arany lab @AranyLab]

Happy to share Nora's paper now in @eLife. Surprise to us: cardiac ECs express genes like troponin, myosin, titin, and do so by keeping open chromatin in those genes. NOT contamination! chromatin closes upon ex vivo culture of ECs... https://t.co/WhvAkO7xB8

[Jonathan Edwards @JonEdwardsMD]

Noncanonical WNT Activation in Human Right Ventricular Heart Failure https://t.co/rGjumIaMsA Or, as I like to say, WNT the right ventricle's had enough!

[Jonathan Edwards @JonEdwardsMD]

https://t.co/rmGeDUpHr0 #powerofdolly

[Jonathan Edwards @JonEdwardsMD]

https://t.co/S3y88X8fLO #powerofdolly #dollypartonsamerica

[Jonathan Edwards @JonEdwardsMD]

March of Dimes #HighImpact #RNAi #PAS2016 #PASMeeting #FillTheRoom @Bruce Gelb https://t.co/haQeWRAVUZ

[SΔJ @SajTheOne]

Here's what #drumpf supporters think "Make America Great Again" Means..

[Last Week Tonight @LastWeekTonight]

#MakeDonaldDrumpfAgain at https://t.co/lKFnns7rbc!