Jon Ghergurovich

Peds PGY-3 @ CHOP | MD @RWJMS | PhD @Princeton, Rabinowitz lab | Interested in immune/ tumor metabolism | Tweets are my own.

[Jon Ghergurovich @JonGMDPhD]

Very excited to share new work from my PhD studies out today in @NatMetabolism! https://t.co/7vD1K0frnl
#cancer #tumormetabolism #cancermetabolism #folate #methionine

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[Lyssiotis Lab @LyssiotisLab]

🚨 New paper alert 🚨

In @BiochemistryACS, we describe discovery & characterization of novel allosteric inhibitor of cytosolic Malic Enzyme 1. Inherent in this discovery is the first description of a novel allosteric, drugable pocket in ME1. #OpenAccess

https://t.co/QTTefpoPDO

[Nature Metabolism @NatMetabolism]

Online now! Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo https://t.co/XlEAIR6Yzm

[Jon Ghergurovich @JonGMDPhD]

@ila_nim @uw_chiefs @UWDeptMedicine Congrats!!!

[Med by Cell Press @MedCellPress]

In this month's issue, you can also find an original research article on the potential of ketogenic diet combined to standard chemotherapy against pancreatic cancer from the Rabinowitz lab: https://t.co/IwlnxURkUr

[Nature Methods @naturemethods]

The spatial organization of metabolic activity in mammalian tissues is visualized and quantified using isotope tracing and MALDI imaging mass spectrometry.
https://t.co/7YeA7vqRsQ

[Majzner_Lab @Majzner_Lab]

Our experience w/GD2 CAR T cells in 4 patients with DIPG/DMG was published today. This work taught us much about how to safely & effectively treat this disease w/CARs. Deeply grateful to patients & families who bravely trusted us as we learned together.https://t.co/QuQrkKbCmn
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[Jon Ghergurovich @JonGMDPhD]

Amazing. https://t.co/ZXJZd4NmlG

[Sean Morrison @SJMorrison_]

Congrats to Arin Aurora for showing the pentose phosphate pathway promotes oxidative stress resistance in metastasizing melanoma cells and that they upregulate other pathways in its absence: they have redundant & layered protection against oxidative stress
https://t.co/N8JxXspIAI

[Nature Metabolism @NatMetabolism]

Online now! Metabolic balance—a masterclass in mass action https://t.co/CWYyopPWKH

[Cell @CellCellPress]

In the latest issue! Drugs used to treat cystic fibrosis act via stabilization of a single domain within CFTR that promotes global folding
#sciencetwitter #CFresearch
@RockefellerUniv
https://t.co/U4dX1k8Zw4

[Nature Metabolism @NatMetabolism]

News & Views | Karthikeyani Chellappa & Joseph Baur (@PennMedicine) discuss a @NatMetabolism paper showing that the effects of caloric restriction are largely mediated by an increase in the daytime peak of NADH concentrations in the liver.

https://t.co/0wwf3AMSSZ

[FrezzaLab @FrezzaLab]

Valine tRNA levels and availability regulate complex I assembly in leukaemia | Nature https://t.co/3tciablWIn

[Jon Ghergurovich @JonGMDPhD]

Excellent post covering how to interpret COVID testing results as we head into holiday season— worth the read for anyone concerned about asymptomatic transmission!

[Jon Ghergurovich @JonGMDPhD]

Congrats Yogesh!!

[Nature Metabolism @NatMetabolism]

Research | The team led by Joshua Rabinowitz (@Princeton) show that methionine synthase is important for tumor cell survival through generating tetrahydrofolate, rather than methionine. #cancerresearch #folate

https://t.co/nJfxYTwMNw

👉https://t.co/DFJgfGz3R0

[FrezzaLab @FrezzaLab]

Congrats to the @ThalesPapaG !

Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition https://t.co/BQOAHwq1lE

[Alicia Darnell @amcdarnell]

Happy to share some new work with former @mvhlab member Mark Sullivan & an awesome parallel study from the Rabinowitz lab! See below for details… https://t.co/4dbQn8zrCv & https://t.co/QqzZGR4MR2

[Jon Ghergurovich @JonGMDPhD]

@amcdarnell @NatMetabolism Thanks @amcdarnell! Congrats to you and your team as well -- it was a fun story to watch unfold, and I'm glad we got to share it together!

[Jon Ghergurovich @JonGMDPhD]

Very excited to share new work from my PhD studies out today in @NatMetabolism! https://t.co/7vD1K0frnl
#cancer #tumormetabolism #cancermetabolism #folate #methionine

1/4

[Jon Ghergurovich @JonGMDPhD]

@jaymehtamd Thanks Jay!

[Jon Ghergurovich @JonGMDPhD]

@HerranzLab @NatMetabolism Thank you!